| Full name: SLX4 structure-specific endonuclease subunit | Alias Symbol: KIAA1784|KIAA1987|FANCP | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 84464 | HGNC ID: HGNC:23845 | Ensembl Gene: ENSG00000188827 | OMIM ID: 613278 |
Screen Evidence:
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Expression of SLX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLX4 | 84464 | 232147_at | 0.3015 | 0.2566 | |
| GSE26886 | SLX4 | 84464 | 232147_at | -0.0903 | 0.7130 | |
| GSE45670 | SLX4 | 84464 | 232147_at | 0.4987 | 0.0000 | |
| GSE53622 | SLX4 | 84464 | 20934 | 0.0625 | 0.4105 | |
| GSE53624 | SLX4 | 84464 | 20934 | 0.0154 | 0.8237 | |
| GSE63941 | SLX4 | 84464 | 232147_at | -0.3420 | 0.1935 | |
| GSE77861 | SLX4 | 84464 | 239687_at | -0.2633 | 0.0398 | |
| GSE97050 | SLX4 | 84464 | A_23_P371129 | 0.3066 | 0.4412 | |
| SRP007169 | SLX4 | 84464 | RNAseq | 1.0324 | 0.0342 | |
| SRP008496 | SLX4 | 84464 | RNAseq | 0.0168 | 0.9600 | |
| SRP064894 | SLX4 | 84464 | RNAseq | 0.4126 | 0.0332 | |
| SRP133303 | SLX4 | 84464 | RNAseq | 0.3740 | 0.0066 | |
| SRP159526 | SLX4 | 84464 | RNAseq | 0.2092 | 0.3929 | |
| SRP193095 | SLX4 | 84464 | RNAseq | 0.4026 | 0.0004 | |
| SRP219564 | SLX4 | 84464 | RNAseq | 0.2688 | 0.4292 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SLX4 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SLX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLX4 | 84464 | 5 | 5 | 20 | |
| GSE20123 | SLX4 | 84464 | 5 | 4 | 21 | |
| GSE43470 | SLX4 | 84464 | 4 | 7 | 32 | |
| GSE46452 | SLX4 | 84464 | 38 | 1 | 20 | |
| GSE47630 | SLX4 | 84464 | 13 | 6 | 21 | |
| GSE54993 | SLX4 | 84464 | 4 | 5 | 61 | |
| GSE54994 | SLX4 | 84464 | 5 | 9 | 39 | |
| GSE60625 | SLX4 | 84464 | 4 | 0 | 7 | |
| GSE74703 | SLX4 | 84464 | 4 | 5 | 27 | |
| GSE74704 | SLX4 | 84464 | 3 | 2 | 15 | |
| TCGA | SLX4 | 84464 | 19 | 14 | 63 |
Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.
Somatic mutations of SLX4:
Generating mutation plots.
Highly correlated genes for SLX4:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLX4 | WRAP53 | 0.736044 | 3 | 0 | 3 |
| SLX4 | TBC1D10B | 0.681121 | 3 | 0 | 3 |
| SLX4 | XPO6 | 0.680071 | 3 | 0 | 3 |
| SLX4 | IGFN1 | 0.670162 | 3 | 0 | 3 |
| SLX4 | TRIM41 | 0.65134 | 3 | 0 | 3 |
| SLX4 | DHH | 0.650516 | 3 | 0 | 3 |
| SLX4 | MYH13 | 0.639662 | 3 | 0 | 3 |
| SLX4 | NOBOX | 0.638077 | 3 | 0 | 3 |
| SLX4 | SEZ6L2 | 0.636152 | 4 | 0 | 3 |
| SLX4 | TMCC2 | 0.628721 | 3 | 0 | 3 |
| SLX4 | PTK2B | 0.623905 | 4 | 0 | 3 |
| SLX4 | GPHA2 | 0.609217 | 4 | 0 | 3 |
| SLX4 | EVA1B | 0.606761 | 3 | 0 | 3 |
| SLX4 | CORT | 0.60084 | 3 | 0 | 3 |
| SLX4 | POC1A | 0.599665 | 4 | 0 | 4 |
| SLX4 | SNAI1 | 0.594173 | 4 | 0 | 3 |
| SLX4 | AKR7A3 | 0.589996 | 4 | 0 | 3 |
| SLX4 | SLC35F3 | 0.583435 | 3 | 0 | 3 |
| SLX4 | KCTD5 | 0.58299 | 4 | 0 | 4 |
| SLX4 | IPO13 | 0.576941 | 4 | 0 | 3 |
For details and further investigation, click here
