| Full name: cyclin G associated kinase | Alias Symbol: DNAJC26 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 2580 | HGNC ID: HGNC:4113 | Ensembl Gene: ENSG00000178950 | OMIM ID: 602052 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GAK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAK | 2580 | 40225_at | 0.1389 | 0.8113 | |
| GSE20347 | GAK | 2580 | 40225_at | -0.4388 | 0.0074 | |
| GSE23400 | GAK | 2580 | 40225_at | -0.3585 | 0.0000 | |
| GSE26886 | GAK | 2580 | 40225_at | -0.1766 | 0.2560 | |
| GSE29001 | GAK | 2580 | 40225_at | -0.3844 | 0.2254 | |
| GSE38129 | GAK | 2580 | 40225_at | -0.2888 | 0.0185 | |
| GSE45670 | GAK | 2580 | 40225_at | -0.0388 | 0.8003 | |
| GSE53622 | GAK | 2580 | 110205 | -0.6515 | 0.0000 | |
| GSE53624 | GAK | 2580 | 110205 | -0.5916 | 0.0000 | |
| GSE63941 | GAK | 2580 | 40225_at | -0.2942 | 0.4470 | |
| GSE77861 | GAK | 2580 | 40225_at | -0.3536 | 0.2103 | |
| GSE97050 | GAK | 2580 | A_24_P397150 | 0.1036 | 0.6364 | |
| SRP007169 | GAK | 2580 | RNAseq | -1.2746 | 0.0017 | |
| SRP008496 | GAK | 2580 | RNAseq | -1.3574 | 0.0000 | |
| SRP064894 | GAK | 2580 | RNAseq | -0.3246 | 0.0557 | |
| SRP133303 | GAK | 2580 | RNAseq | -0.5730 | 0.0000 | |
| SRP159526 | GAK | 2580 | RNAseq | -0.6774 | 0.0070 | |
| SRP193095 | GAK | 2580 | RNAseq | -0.4855 | 0.0083 | |
| SRP219564 | GAK | 2580 | RNAseq | -0.1490 | 0.6885 | |
| TCGA | GAK | 2580 | RNAseq | -0.2378 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GAK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GAK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAK | 2580 | 0 | 17 | 13 | |
| GSE20123 | GAK | 2580 | 0 | 15 | 15 | |
| GSE43470 | GAK | 2580 | 0 | 17 | 26 | |
| GSE46452 | GAK | 2580 | 1 | 36 | 22 | |
| GSE47630 | GAK | 2580 | 3 | 19 | 18 | |
| GSE54993 | GAK | 2580 | 11 | 0 | 59 | |
| GSE54994 | GAK | 2580 | 3 | 12 | 38 | |
| GSE60625 | GAK | 2580 | 0 | 0 | 11 | |
| GSE74703 | GAK | 2580 | 0 | 13 | 23 | |
| GSE74704 | GAK | 2580 | 0 | 8 | 12 | |
| TCGA | GAK | 2580 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 184; Total Number of normals: 277.
Somatic mutations of GAK:
Generating mutation plots.
Highly correlated genes for GAK:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAK | MARK4 | 0.76604 | 3 | 0 | 3 |
| GAK | ZC3H3 | 0.739521 | 4 | 0 | 4 |
| GAK | GDF5 | 0.734693 | 3 | 0 | 3 |
| GAK | BIRC6 | 0.70172 | 3 | 0 | 3 |
| GAK | NOL12 | 0.698232 | 4 | 0 | 4 |
| GAK | SNRNP70 | 0.698015 | 4 | 0 | 4 |
| GAK | PWWP2A | 0.691965 | 3 | 0 | 3 |
| GAK | ZNF814 | 0.69028 | 4 | 0 | 3 |
| GAK | SREBF2 | 0.690031 | 5 | 0 | 4 |
| GAK | NFXL1 | 0.688084 | 3 | 0 | 3 |
| GAK | PIAS3 | 0.676557 | 4 | 0 | 3 |
| GAK | HMGN1 | 0.674848 | 4 | 0 | 3 |
| GAK | SCAMP4 | 0.672809 | 5 | 0 | 3 |
| GAK | MROH1 | 0.672049 | 3 | 0 | 3 |
| GAK | AKAP8L | 0.67066 | 4 | 0 | 3 |
| GAK | SHISA5 | 0.666086 | 5 | 0 | 5 |
| GAK | SLC4A5 | 0.662671 | 3 | 0 | 3 |
| GAK | STAT2 | 0.662449 | 3 | 0 | 3 |
| GAK | MTHFR | 0.659232 | 4 | 0 | 4 |
| GAK | LRP11 | 0.657756 | 3 | 0 | 3 |
For details and further investigation, click here
