| Full name: zinc finger homeobox 4 | Alias Symbol: ZFH4|FLJ20980 | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 79776 | HGNC ID: HGNC:30939 | Ensembl Gene: ENSG00000091656 | OMIM ID: 606940 |
| Drug and gene relationship at DGIdb | |||
Expression of ZFHX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZFHX4 | 79776 | 219779_at | 0.3311 | 0.7558 | |
| GSE20347 | ZFHX4 | 79776 | 219779_at | 0.6852 | 0.0003 | |
| GSE23400 | ZFHX4 | 79776 | 219779_at | 0.1548 | 0.0722 | |
| GSE26886 | ZFHX4 | 79776 | 219779_at | 0.2340 | 0.2493 | |
| GSE29001 | ZFHX4 | 79776 | 219779_at | -0.0174 | 0.9435 | |
| GSE38129 | ZFHX4 | 79776 | 219779_at | 0.2378 | 0.3132 | |
| GSE45670 | ZFHX4 | 79776 | 219779_at | 0.1858 | 0.3086 | |
| GSE53622 | ZFHX4 | 79776 | 39852 | 0.6591 | 0.0009 | |
| GSE53624 | ZFHX4 | 79776 | 39852 | 1.0149 | 0.0000 | |
| GSE63941 | ZFHX4 | 79776 | 219779_at | -1.4630 | 0.0139 | |
| GSE77861 | ZFHX4 | 79776 | 219779_at | 0.0451 | 0.7809 | |
| SRP007169 | ZFHX4 | 79776 | RNAseq | 4.4328 | 0.0000 | |
| SRP064894 | ZFHX4 | 79776 | RNAseq | 2.5244 | 0.0000 | |
| SRP133303 | ZFHX4 | 79776 | RNAseq | 1.4668 | 0.0000 | |
| SRP159526 | ZFHX4 | 79776 | RNAseq | 2.0617 | 0.0049 | |
| SRP193095 | ZFHX4 | 79776 | RNAseq | 1.7559 | 0.0000 | |
| SRP219564 | ZFHX4 | 79776 | RNAseq | 0.0794 | 0.9349 | |
| TCGA | ZFHX4 | 79776 | RNAseq | 0.1311 | 0.4975 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by ZFHX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZFHX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZFHX4 | 79776 | 15 | 1 | 14 | |
| GSE20123 | ZFHX4 | 79776 | 17 | 1 | 12 | |
| GSE43470 | ZFHX4 | 79776 | 18 | 1 | 24 | |
| GSE46452 | ZFHX4 | 79776 | 21 | 0 | 38 | |
| GSE47630 | ZFHX4 | 79776 | 23 | 0 | 17 | |
| GSE54993 | ZFHX4 | 79776 | 0 | 19 | 51 | |
| GSE54994 | ZFHX4 | 79776 | 30 | 0 | 23 | |
| GSE60625 | ZFHX4 | 79776 | 0 | 4 | 7 | |
| GSE74703 | ZFHX4 | 79776 | 15 | 1 | 20 | |
| GSE74704 | ZFHX4 | 79776 | 11 | 0 | 9 | |
| TCGA | ZFHX4 | 79776 | 52 | 2 | 42 |
Total number of gains: 202; Total number of losses: 29; Total Number of normals: 257.
Somatic mutations of ZFHX4:
Generating mutation plots.
Highly correlated genes for ZFHX4:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZFHX4 | SEC23A | 0.652938 | 4 | 0 | 4 |
| ZFHX4 | CORO2B | 0.634946 | 4 | 0 | 4 |
| ZFHX4 | NR2E1 | 0.634762 | 4 | 0 | 3 |
| ZFHX4 | PDE5A | 0.626896 | 3 | 0 | 3 |
| ZFHX4 | LRRN4CL | 0.619544 | 3 | 0 | 3 |
| ZFHX4 | MAP4 | 0.618526 | 4 | 0 | 3 |
| ZFHX4 | GPR85 | 0.617227 | 3 | 0 | 3 |
| ZFHX4 | FNDC1 | 0.615467 | 3 | 0 | 3 |
| ZFHX4 | LYPD6 | 0.614181 | 3 | 0 | 3 |
| ZFHX4 | PNMA2 | 0.613869 | 4 | 0 | 3 |
| ZFHX4 | NLGN1 | 0.610633 | 4 | 0 | 3 |
| ZFHX4 | LRRC34 | 0.607891 | 3 | 0 | 3 |
| ZFHX4 | SORBS3 | 0.60403 | 4 | 0 | 4 |
| ZFHX4 | SNORA78 | 0.597938 | 3 | 0 | 3 |
| ZFHX4 | SYDE1 | 0.597924 | 8 | 0 | 7 |
| ZFHX4 | ADAMTS12 | 0.597577 | 4 | 0 | 3 |
| ZFHX4 | PDGFRL | 0.596705 | 6 | 0 | 5 |
| ZFHX4 | ISLR | 0.595438 | 6 | 0 | 4 |
| ZFHX4 | AAMDC | 0.589133 | 4 | 0 | 3 |
| ZFHX4 | LAMC1 | 0.58818 | 5 | 0 | 3 |
For details and further investigation, click here
