| Full name: G protein-coupled receptor 85 | Alias Symbol: SREB2 | ||
| Type: protein-coding gene | Cytoband: 7q31.1 | ||
| Entrez ID: 54329 | HGNC ID: HGNC:4536 | Ensembl Gene: ENSG00000164604 | OMIM ID: 605188 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR85:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR85 | 54329 | 234303_s_at | 0.3867 | 0.1601 | |
| GSE20347 | GPR85 | 54329 | 219898_at | 0.0182 | 0.7608 | |
| GSE23400 | GPR85 | 54329 | 219898_at | 0.0009 | 0.9581 | |
| GSE26886 | GPR85 | 54329 | 234303_s_at | 0.6321 | 0.0241 | |
| GSE29001 | GPR85 | 54329 | 219898_at | -0.0333 | 0.8099 | |
| GSE38129 | GPR85 | 54329 | 219898_at | 0.0365 | 0.5327 | |
| GSE45670 | GPR85 | 54329 | 234303_s_at | 0.1195 | 0.3469 | |
| GSE53622 | GPR85 | 54329 | 28258 | 0.5836 | 0.0005 | |
| GSE53624 | GPR85 | 54329 | 28258 | 0.2763 | 0.0157 | |
| GSE63941 | GPR85 | 54329 | 234303_s_at | -1.9546 | 0.0339 | |
| GSE77861 | GPR85 | 54329 | 234303_s_at | 0.1334 | 0.0993 | |
| SRP064894 | GPR85 | 54329 | RNAseq | 0.4925 | 0.0255 | |
| SRP133303 | GPR85 | 54329 | RNAseq | 0.2089 | 0.1618 | |
| SRP159526 | GPR85 | 54329 | RNAseq | 0.3453 | 0.4805 | |
| SRP193095 | GPR85 | 54329 | RNAseq | 0.3105 | 0.0208 | |
| SRP219564 | GPR85 | 54329 | RNAseq | 0.3449 | 0.3696 | |
| TCGA | GPR85 | 54329 | RNAseq | 0.8993 | 0.0017 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GPR85 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR85:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR85 | 54329 | 10 | 2 | 18 | |
| GSE20123 | GPR85 | 54329 | 11 | 2 | 17 | |
| GSE43470 | GPR85 | 54329 | 4 | 2 | 37 | |
| GSE46452 | GPR85 | 54329 | 8 | 1 | 50 | |
| GSE47630 | GPR85 | 54329 | 7 | 4 | 29 | |
| GSE54993 | GPR85 | 54329 | 2 | 8 | 60 | |
| GSE54994 | GPR85 | 54329 | 12 | 5 | 36 | |
| GSE60625 | GPR85 | 54329 | 0 | 0 | 11 | |
| GSE74703 | GPR85 | 54329 | 4 | 2 | 30 | |
| GSE74704 | GPR85 | 54329 | 7 | 2 | 11 | |
| TCGA | GPR85 | 54329 | 36 | 16 | 44 |
Total number of gains: 101; Total number of losses: 44; Total Number of normals: 343.
Somatic mutations of GPR85:
Generating mutation plots.
Highly correlated genes for GPR85:
Showing top 20/129 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR85 | HAUS8 | 0.725123 | 3 | 0 | 3 |
| GPR85 | MMP10 | 0.716892 | 3 | 0 | 3 |
| GPR85 | DTL | 0.713866 | 3 | 0 | 3 |
| GPR85 | SEMA4F | 0.712737 | 3 | 0 | 3 |
| GPR85 | CDCA3 | 0.709135 | 3 | 0 | 3 |
| GPR85 | NCAPD2 | 0.695975 | 3 | 0 | 3 |
| GPR85 | PIF1 | 0.679674 | 3 | 0 | 3 |
| GPR85 | TREM1 | 0.669595 | 3 | 0 | 3 |
| GPR85 | SYDE1 | 0.663925 | 3 | 0 | 3 |
| GPR85 | FEN1 | 0.663346 | 3 | 0 | 3 |
| GPR85 | TNC | 0.663028 | 3 | 0 | 3 |
| GPR85 | UHRF1 | 0.662625 | 3 | 0 | 3 |
| GPR85 | NCAPH | 0.661693 | 3 | 0 | 3 |
| GPR85 | TIMELESS | 0.660775 | 3 | 0 | 3 |
| GPR85 | CDCA2 | 0.659459 | 3 | 0 | 3 |
| GPR85 | SPAG5 | 0.653786 | 3 | 0 | 3 |
| GPR85 | HJURP | 0.652338 | 3 | 0 | 3 |
| GPR85 | CDC6 | 0.651715 | 3 | 0 | 3 |
| GPR85 | POP7 | 0.648329 | 3 | 0 | 3 |
| GPR85 | CUX1 | 0.63995 | 3 | 0 | 3 |
For details and further investigation, click here
