| Full name: arylacetamide deacetylase | Alias Symbol: DAC|CES5A1 | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 13 | HGNC ID: HGNC:17 | Ensembl Gene: ENSG00000114771 | OMIM ID: 600338 |
| Drug and gene relationship at DGIdb | |||
Expression of AADAC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AADAC | 13 | 205969_at | -0.4762 | 0.3859 | |
| GSE20347 | AADAC | 13 | 205969_at | -0.4547 | 0.2276 | |
| GSE23400 | AADAC | 13 | 205969_at | 0.1195 | 0.4169 | |
| GSE26886 | AADAC | 13 | 205969_at | -0.8266 | 0.1325 | |
| GSE29001 | AADAC | 13 | 205969_at | -0.5274 | 0.2988 | |
| GSE38129 | AADAC | 13 | 205969_at | -0.2886 | 0.4316 | |
| GSE45670 | AADAC | 13 | 205969_at | -0.5115 | 0.4275 | |
| GSE53622 | AADAC | 13 | 59051 | -1.7739 | 0.0000 | |
| GSE53624 | AADAC | 13 | 59051 | -1.6414 | 0.0000 | |
| GSE63941 | AADAC | 13 | 205969_at | -0.5968 | 0.5346 | |
| GSE77861 | AADAC | 13 | 205969_at | 1.4006 | 0.0819 | |
| SRP133303 | AADAC | 13 | RNAseq | -0.9776 | 0.1580 | |
| SRP159526 | AADAC | 13 | RNAseq | 0.5987 | 0.5107 | |
| SRP193095 | AADAC | 13 | RNAseq | -1.4995 | 0.0061 | |
| SRP219564 | AADAC | 13 | RNAseq | -0.2378 | 0.7993 | |
| TCGA | AADAC | 13 | RNAseq | -1.1099 | 0.0334 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by AADAC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AADAC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AADAC | 13 | 21 | 0 | 9 | |
| GSE20123 | AADAC | 13 | 21 | 0 | 9 | |
| GSE43470 | AADAC | 13 | 23 | 0 | 20 | |
| GSE46452 | AADAC | 13 | 18 | 2 | 39 | |
| GSE47630 | AADAC | 13 | 19 | 3 | 18 | |
| GSE54993 | AADAC | 13 | 1 | 10 | 59 | |
| GSE54994 | AADAC | 13 | 37 | 1 | 15 | |
| GSE60625 | AADAC | 13 | 0 | 6 | 5 | |
| GSE74703 | AADAC | 13 | 20 | 0 | 16 | |
| GSE74704 | AADAC | 13 | 14 | 0 | 6 | |
| TCGA | AADAC | 13 | 73 | 1 | 22 |
Total number of gains: 247; Total number of losses: 23; Total Number of normals: 218.
Somatic mutations of AADAC:
Generating mutation plots.
Highly correlated genes for AADAC:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AADAC | CYP2C9 | 0.632488 | 4 | 0 | 4 |
| AADAC | EIF4ENIF1 | 0.605712 | 3 | 0 | 3 |
| AADAC | PGAP2 | 0.592948 | 5 | 0 | 3 |
| AADAC | RASSF7 | 0.585492 | 4 | 0 | 3 |
| AADAC | ALKBH7 | 0.569972 | 4 | 0 | 3 |
| AADAC | PLEKHA5 | 0.569661 | 3 | 0 | 3 |
| AADAC | SOX21-AS1 | 0.567291 | 5 | 0 | 3 |
| AADAC | HDHD3 | 0.565189 | 4 | 0 | 3 |
| AADAC | PLEKHG1 | 0.563773 | 5 | 0 | 4 |
| AADAC | LIPH | 0.560729 | 5 | 0 | 3 |
| AADAC | COX6A1 | 0.557469 | 3 | 0 | 3 |
| AADAC | SPTSSB | 0.55346 | 4 | 0 | 3 |
| AADAC | SLC9A3R1 | 0.547722 | 5 | 0 | 3 |
| AADAC | ALDH1A1 | 0.547658 | 8 | 0 | 4 |
| AADAC | WEE1 | 0.540049 | 4 | 0 | 3 |
| AADAC | SAMD5 | 0.537931 | 4 | 0 | 3 |
| AADAC | TMEM62 | 0.53553 | 4 | 0 | 3 |
| AADAC | TRMT10A | 0.535186 | 4 | 0 | 3 |
| AADAC | KLF3 | 0.533183 | 5 | 0 | 4 |
| AADAC | ADH7 | 0.528773 | 8 | 0 | 5 |
For details and further investigation, click here
