| Full name: acyl-CoA dehydrogenase long chain | Alias Symbol: LCAD|ACAD4 | ||
| Type: protein-coding gene | Cytoband: 2q34 | ||
| Entrez ID: 33 | HGNC ID: HGNC:88 | Ensembl Gene: ENSG00000115361 | OMIM ID: 609576 |
| Drug and gene relationship at DGIdb | |||
ACADL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of ACADL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACADL | 33 | 206068_s_at | -0.2442 | 0.7856 | |
| GSE20347 | ACADL | 33 | 206068_s_at | -0.2110 | 0.0068 | |
| GSE23400 | ACADL | 33 | 206069_s_at | -0.0110 | 0.7097 | |
| GSE26886 | ACADL | 33 | 206068_s_at | 0.0561 | 0.8526 | |
| GSE29001 | ACADL | 33 | 206069_s_at | -0.2948 | 0.1571 | |
| GSE38129 | ACADL | 33 | 206068_s_at | -0.3988 | 0.0095 | |
| GSE45670 | ACADL | 33 | 206068_s_at | -0.8184 | 0.0111 | |
| GSE53622 | ACADL | 33 | 17759 | -2.3683 | 0.0000 | |
| GSE53624 | ACADL | 33 | 17759 | -2.8875 | 0.0000 | |
| GSE63941 | ACADL | 33 | 206068_s_at | 0.3597 | 0.6051 | |
| GSE77861 | ACADL | 33 | 206068_s_at | 0.0045 | 0.9744 | |
| SRP064894 | ACADL | 33 | RNAseq | -1.6483 | 0.0036 | |
| SRP133303 | ACADL | 33 | RNAseq | -0.1079 | 0.8824 | |
| SRP159526 | ACADL | 33 | RNAseq | 0.5686 | 0.2027 | |
| TCGA | ACADL | 33 | RNAseq | -2.3648 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ACADL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACADL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACADL | 33 | 2 | 12 | 16 | |
| GSE20123 | ACADL | 33 | 2 | 12 | 16 | |
| GSE43470 | ACADL | 33 | 1 | 6 | 36 | |
| GSE46452 | ACADL | 33 | 0 | 5 | 54 | |
| GSE47630 | ACADL | 33 | 4 | 5 | 31 | |
| GSE54993 | ACADL | 33 | 0 | 3 | 67 | |
| GSE54994 | ACADL | 33 | 9 | 9 | 35 | |
| GSE60625 | ACADL | 33 | 0 | 3 | 8 | |
| GSE74703 | ACADL | 33 | 1 | 5 | 30 | |
| GSE74704 | ACADL | 33 | 2 | 6 | 12 | |
| TCGA | ACADL | 33 | 12 | 24 | 60 |
Total number of gains: 33; Total number of losses: 90; Total Number of normals: 365.
Somatic mutations of ACADL:
Generating mutation plots.
Highly correlated genes for ACADL:
Showing top 20/323 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACADL | CHST9 | 0.697123 | 5 | 0 | 5 |
| ACADL | TMPRSS2 | 0.695656 | 3 | 0 | 3 |
| ACADL | LRRK2 | 0.65625 | 3 | 0 | 3 |
| ACADL | TCEA3 | 0.645713 | 4 | 0 | 4 |
| ACADL | FAM221A | 0.643546 | 4 | 0 | 4 |
| ACADL | NFIX | 0.641584 | 3 | 0 | 3 |
| ACADL | VSIG2 | 0.637761 | 4 | 0 | 3 |
| ACADL | PPM1L | 0.634177 | 5 | 0 | 4 |
| ACADL | HYKK | 0.63096 | 4 | 0 | 4 |
| ACADL | PPP1R9A | 0.628888 | 5 | 0 | 4 |
| ACADL | GALNT12 | 0.625086 | 5 | 0 | 5 |
| ACADL | SH3BGRL2 | 0.618587 | 4 | 0 | 3 |
| ACADL | ADH1C | 0.617783 | 5 | 0 | 4 |
| ACADL | USP9X | 0.617055 | 4 | 0 | 4 |
| ACADL | PAIP2B | 0.614615 | 5 | 0 | 4 |
| ACADL | KRT78 | 0.611915 | 3 | 0 | 3 |
| ACADL | FAM214A | 0.611209 | 3 | 0 | 3 |
| ACADL | USP54 | 0.609428 | 4 | 0 | 4 |
| ACADL | IL12A-AS1 | 0.606603 | 3 | 0 | 3 |
| ACADL | KBTBD3 | 0.606233 | 3 | 0 | 3 |
For details and further investigation, click here
