| Full name: secreted phosphoprotein 1 | Alias Symbol: BSPI|ETA-1 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 6696 | HGNC ID: HGNC:11255 | Ensembl Gene: ENSG00000118785 | OMIM ID: 166490 |
| Drug and gene relationship at DGIdb | |||
SPP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04620 | Toll-like receptor signaling pathway |
Expression of SPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPP1 | 6696 | 209875_s_at | 3.2802 | 0.0430 | |
| GSE20347 | SPP1 | 6696 | 209875_s_at | 4.6129 | 0.0000 | |
| GSE23400 | SPP1 | 6696 | 209875_s_at | 3.6709 | 0.0000 | |
| GSE26886 | SPP1 | 6696 | 209875_s_at | 5.5310 | 0.0000 | |
| GSE29001 | SPP1 | 6696 | 209875_s_at | 4.0513 | 0.0000 | |
| GSE38129 | SPP1 | 6696 | 209875_s_at | 5.0502 | 0.0000 | |
| GSE45670 | SPP1 | 6696 | 209875_s_at | 3.0925 | 0.0003 | |
| GSE53622 | SPP1 | 6696 | 25787 | 5.0271 | 0.0000 | |
| GSE53624 | SPP1 | 6696 | 25787 | 5.0582 | 0.0000 | |
| GSE63941 | SPP1 | 6696 | 209875_s_at | 1.0793 | 0.7648 | |
| GSE77861 | SPP1 | 6696 | 209875_s_at | 4.0664 | 0.0017 | |
| GSE97050 | SPP1 | 6696 | A_23_P7313 | 2.5601 | 0.0454 | |
| SRP008496 | SPP1 | 6696 | RNAseq | 8.1435 | 0.0000 | |
| SRP064894 | SPP1 | 6696 | RNAseq | 6.6170 | 0.0000 | |
| SRP133303 | SPP1 | 6696 | RNAseq | 6.0016 | 0.0000 | |
| SRP159526 | SPP1 | 6696 | RNAseq | 5.1716 | 0.0000 | |
| SRP219564 | SPP1 | 6696 | RNAseq | 5.7032 | 0.0000 | |
| TCGA | SPP1 | 6696 | RNAseq | 1.7039 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by SPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPP1 | 6696 | 3 | 12 | 15 | |
| GSE20123 | SPP1 | 6696 | 3 | 12 | 15 | |
| GSE43470 | SPP1 | 6696 | 0 | 13 | 30 | |
| GSE46452 | SPP1 | 6696 | 1 | 36 | 22 | |
| GSE47630 | SPP1 | 6696 | 0 | 20 | 20 | |
| GSE54993 | SPP1 | 6696 | 8 | 0 | 62 | |
| GSE54994 | SPP1 | 6696 | 1 | 9 | 43 | |
| GSE60625 | SPP1 | 6696 | 0 | 0 | 11 | |
| GSE74703 | SPP1 | 6696 | 0 | 11 | 25 | |
| GSE74704 | SPP1 | 6696 | 2 | 7 | 11 | |
| TCGA | SPP1 | 6696 | 12 | 36 | 48 |
Total number of gains: 30; Total number of losses: 156; Total Number of normals: 302.
Somatic mutations of SPP1:
Generating mutation plots.
Highly correlated genes for SPP1:
Showing top 20/1787 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPP1 | MMP11 | 0.826001 | 9 | 0 | 9 |
| SPP1 | MMP1 | 0.813528 | 11 | 0 | 11 |
| SPP1 | MFAP2 | 0.805659 | 11 | 0 | 11 |
| SPP1 | SNX10 | 0.795731 | 11 | 0 | 11 |
| SPP1 | POSTN | 0.787488 | 11 | 0 | 10 |
| SPP1 | LAMC2 | 0.783408 | 11 | 0 | 11 |
| SPP1 | COL5A2 | 0.781669 | 11 | 0 | 10 |
| SPP1 | COL1A1 | 0.778566 | 10 | 0 | 8 |
| SPP1 | TTYH3 | 0.773242 | 7 | 0 | 7 |
| SPP1 | SERPINH1 | 0.769212 | 11 | 0 | 11 |
| SPP1 | WDR54 | 0.768545 | 6 | 0 | 6 |
| SPP1 | INHBA | 0.768101 | 11 | 0 | 10 |
| SPP1 | PLAU | 0.765454 | 11 | 0 | 11 |
| SPP1 | CTHRC1 | 0.764192 | 8 | 0 | 7 |
| SPP1 | TMEM138 | 0.761642 | 5 | 0 | 5 |
| SPP1 | MMP12 | 0.758035 | 11 | 0 | 11 |
| SPP1 | COL10A1 | 0.756021 | 12 | 0 | 11 |
| SPP1 | COL12A1 | 0.753534 | 5 | 0 | 4 |
| SPP1 | TGFBI | 0.751934 | 11 | 0 | 11 |
| SPP1 | C4orf48 | 0.749962 | 7 | 0 | 7 |
For details and further investigation, click here
