TWIST1

 

Full name: twist family bHLH transcription factor 1 Alias Symbol: SCS|H-twist|BPES2|bHLHa38|CRS1
Type: protein-coding gene Cytoband: 7p21.1
Entrez ID: 7291 HGNC ID: HGNC:12428 Ensembl Gene: ENSG00000122691 OMIM ID: 601622
Drug and gene relationship at DGIdb

 

TWIST1 involved pathways:

KEGG pathway Description View
hsa05205Proteoglycans in cancer

 

Expression of TWIST1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TWIST1 7291 213943_at 0.8339 0.4284
GSE20347 TWIST1 7291 213943_at 1.2705 0.0001
GSE23400 TWIST1 7291 213943_at 0.5868 0.0000
GSE26886 TWIST1 7291 213943_at 3.4625 0.0000
GSE29001 TWIST1 7291 213943_at 1.5563 0.0008
GSE38129 TWIST1 7291 213943_at 1.1389 0.0002
GSE45670 TWIST1 7291 213943_at -0.9440 0.1013
GSE53622 TWIST1 7291 983 0.6438 0.0000
GSE53624 TWIST1 7291 983 0.6974 0.0000
GSE63941 TWIST1 7291 213943_at -2.8604 0.0384
GSE77861 TWIST1 7291 213943_at 0.8520 0.0550
GSE97050 TWIST1 7291 A_33_P3414591 0.1168 0.6835
SRP007169 TWIST1 7291 RNAseq 2.1742 0.0037
SRP008496 TWIST1 7291 RNAseq 2.5228 0.0001
SRP064894 TWIST1 7291 RNAseq 1.1124 0.0008
SRP133303 TWIST1 7291 RNAseq 1.2397 0.0028
SRP159526 TWIST1 7291 RNAseq 0.9504 0.0310
SRP219564 TWIST1 7291 RNAseq 1.5327 0.0024
TCGA TWIST1 7291 RNAseq 0.9809 0.0000

Upregulated datasets: 9; Downregulated datasets: 1.  

 

Survival by TWIST1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TWIST1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TWIST1 7291 15 2 13
GSE20123 TWIST1 7291 15 2 13
GSE43470 TWIST1 7291 4 0 39
GSE46452 TWIST1 7291 11 1 47
GSE47630 TWIST1 7291 9 1 30
GSE54993 TWIST1 7291 0 6 64
GSE54994 TWIST1 7291 20 2 31
GSE60625 TWIST1 7291 0 0 11
GSE74703 TWIST1 7291 4 0 32
GSE74704 TWIST1 7291 9 2 9
TCGA TWIST1 7291 56 5 35

Total number of gains: 143; Total number of losses: 21; Total Number of normals: 324.  

 

Somatic mutations of TWIST1:

 

Generating mutation plots.

 

Highly correlated genes for TWIST1:

 

Showing top 20/998 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TWIST1GEMIN50.714615303
TWIST1SLC9A10.707772303
TWIST1SNAPC40.699084303
TWIST1LRRC8C0.692496303
TWIST1TNFAIP60.69244713013
TWIST1ADAMTS150.692127303
TWIST1SORBS30.691379303
TWIST1SRRT0.689623505
TWIST1TRIM470.689341303
TWIST1FRMD6-AS10.68693404
TWIST1PDGFRB0.68689612012
TWIST1FSTL10.68520512012
TWIST1CDH110.67864613011
TWIST1COL5A20.67613613013
TWIST1AEBP10.67471112012
TWIST1AP3D10.672716303
TWIST1FAM126A0.6709404
TWIST1COL5A10.66847413011
TWIST1COL6A30.66642213012
TWIST1BEND60.66352606

For details and further investigation, click here