ADAT2

 

Full name: adenosine deaminase tRNA specific 2 Alias Symbol: dJ20N2.1|TAD2
Type: protein-coding gene Cytoband: 6q24.2
Entrez ID: 134637 HGNC ID: HGNC:21172 Ensembl Gene: ENSG00000189007 OMIM ID: 615388
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ADAT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADAT2 134637 227213_at 0.4891 0.4558
GSE26886 ADAT2 134637 227213_at 0.5491 0.0423
GSE45670 ADAT2 134637 227213_at 0.2188 0.1547
GSE53622 ADAT2 134637 13090 0.2287 0.0090
GSE53624 ADAT2 134637 13090 0.1754 0.0232
GSE63941 ADAT2 134637 227213_at -0.3837 0.4982
GSE77861 ADAT2 134637 227213_at 0.1301 0.6615
GSE97050 ADAT2 134637 A_33_P3602006 -0.0377 0.8958
SRP007169 ADAT2 134637 RNAseq 0.1064 0.8187
SRP008496 ADAT2 134637 RNAseq 0.1991 0.6206
SRP064894 ADAT2 134637 RNAseq 0.0477 0.8310
SRP133303 ADAT2 134637 RNAseq -0.1066 0.2950
SRP159526 ADAT2 134637 RNAseq -0.5634 0.0534
SRP193095 ADAT2 134637 RNAseq -0.1486 0.1340
SRP219564 ADAT2 134637 RNAseq -0.1560 0.7080
TCGA ADAT2 134637 RNAseq -0.0514 0.4774

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ADAT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADAT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADAT2 134637 2 4 24
GSE20123 ADAT2 134637 2 3 25
GSE43470 ADAT2 134637 5 0 38
GSE46452 ADAT2 134637 3 10 46
GSE47630 ADAT2 134637 9 4 27
GSE54993 ADAT2 134637 3 2 65
GSE54994 ADAT2 134637 8 8 37
GSE60625 ADAT2 134637 0 1 10
GSE74703 ADAT2 134637 4 0 32
GSE74704 ADAT2 134637 0 1 19
TCGA ADAT2 134637 11 19 66

Total number of gains: 47; Total number of losses: 52; Total Number of normals: 389.  

 

Somatic mutations of ADAT2:

 

Generating mutation plots.

 

Highly correlated genes for ADAT2:

 

Showing top 20/46 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADAT2BCCIP0.715785303
ADAT2ZNF1210.659377404
ADAT2VCPKMT0.638388303
ADAT2HDAC70.637349303
ADAT2EXOSC20.623269303
ADAT2PRPF40A0.619125303
ADAT2DVL20.604546303
ADAT2FIP1L10.603709403
ADAT2WDR30.601198403
ADAT2FRMD6-AS10.596221503
ADAT2PLEKHH10.593533403
ADAT2RPL370.586714403
ADAT2WDR700.585895404
ADAT2MTERF30.581146303
ADAT2MTPAP0.576596503
ADAT2LYAR0.575693604
ADAT2ABCD40.569074403
ADAT2PSMG40.568921403
ADAT2PDCD50.567407403
ADAT2C1orf520.564696503

For details and further investigation, click here