EXOSC2

 

Full name: exosome component 2 Alias Symbol: hRrp4p|Rrp4p|RRP4|p7
Type: protein-coding gene Cytoband: 9q34.12
Entrez ID: 23404 HGNC ID: HGNC:17097 Ensembl Gene: ENSG00000130713 OMIM ID: 602238
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of EXOSC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXOSC2 23404 209527_at 0.5919 0.0791
GSE20347 EXOSC2 23404 209527_at 0.4409 0.0021
GSE23400 EXOSC2 23404 209527_at 0.4636 0.0000
GSE26886 EXOSC2 23404 209527_at 1.2250 0.0000
GSE29001 EXOSC2 23404 209527_at 0.7987 0.0075
GSE38129 EXOSC2 23404 209527_at 0.4029 0.0011
GSE45670 EXOSC2 23404 209527_at 0.2960 0.0479
GSE53622 EXOSC2 23404 2867 0.5858 0.0000
GSE53624 EXOSC2 23404 2867 0.7193 0.0000
GSE63941 EXOSC2 23404 214507_s_at 2.1229 0.0001
GSE77861 EXOSC2 23404 214507_s_at 0.3502 0.0353
GSE97050 EXOSC2 23404 A_33_P3347132 0.1713 0.5586
SRP007169 EXOSC2 23404 RNAseq 0.8645 0.0370
SRP008496 EXOSC2 23404 RNAseq 0.6728 0.0070
SRP064894 EXOSC2 23404 RNAseq 0.6669 0.0003
SRP133303 EXOSC2 23404 RNAseq 0.5502 0.0010
SRP159526 EXOSC2 23404 RNAseq 0.9191 0.0000
SRP193095 EXOSC2 23404 RNAseq 0.4677 0.0000
SRP219564 EXOSC2 23404 RNAseq 0.2457 0.3724
TCGA EXOSC2 23404 RNAseq 0.2462 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by EXOSC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXOSC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXOSC2 23404 6 9 15
GSE20123 EXOSC2 23404 6 9 15
GSE43470 EXOSC2 23404 5 7 31
GSE46452 EXOSC2 23404 6 13 40
GSE47630 EXOSC2 23404 3 16 21
GSE54993 EXOSC2 23404 3 3 64
GSE54994 EXOSC2 23404 12 9 32
GSE60625 EXOSC2 23404 0 0 11
GSE74703 EXOSC2 23404 5 5 26
GSE74704 EXOSC2 23404 3 7 10
TCGA EXOSC2 23404 27 26 43

Total number of gains: 76; Total number of losses: 104; Total Number of normals: 308.  

 

Somatic mutations of EXOSC2:

 

Generating mutation plots.

 

Highly correlated genes for EXOSC2:

 

Showing top 20/1050 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXOSC2INO80B0.719855303
EXOSC2NOB10.712776403
EXOSC2DNAJC300.707626404
EXOSC2LINC010040.683316303
EXOSC2CMSS10.683205707
EXOSC2WDR50.68069706
EXOSC2AP1S30.674212404
EXOSC2PUS10.672813908
EXOSC2EME10.665209606
EXOSC2PNPT10.663506707
EXOSC2CREG20.663132303
EXOSC2DNLZ0.658638403
EXOSC2RHPN20.655937504
EXOSC2FUCA20.655465403
EXOSC2IPO90.655418908
EXOSC2RBM280.653037807
EXOSC2MRPL500.652865909
EXOSC2MTRR0.651966606
EXOSC2MRPS170.649755908
EXOSC2NTMT10.648769606

For details and further investigation, click here