ADORA2B

 

Full name: adenosine A2b receptor Alias Symbol: 
Type: protein-coding gene Cytoband: 17p12
Entrez ID: 136 HGNC ID: HGNC:264 Ensembl Gene: ENSG00000170425 OMIM ID: 600446
Drug and gene relationship at DGIdb

 

ADORA2B involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05034Alcoholism

 

Expression of ADORA2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADORA2B 136 205891_at 0.6851 0.3772
GSE20347 ADORA2B 136 205891_at 0.8325 0.0064
GSE23400 ADORA2B 136 205891_at 0.9549 0.0000
GSE26886 ADORA2B 136 205891_at 1.2902 0.0037
GSE29001 ADORA2B 136 205891_at 0.7020 0.0542
GSE38129 ADORA2B 136 205891_at 1.5420 0.0000
GSE45670 ADORA2B 136 205891_at 0.8493 0.0038
GSE53622 ADORA2B 136 2435 0.8725 0.0000
GSE53624 ADORA2B 136 2435 0.9785 0.0000
GSE63941 ADORA2B 136 205891_at 1.5854 0.1169
GSE77861 ADORA2B 136 205891_at 0.8148 0.1362
GSE97050 ADORA2B 136 A_23_P55477 0.9369 0.0903
SRP007169 ADORA2B 136 RNAseq 1.3665 0.0085
SRP008496 ADORA2B 136 RNAseq 0.9638 0.0063
SRP064894 ADORA2B 136 RNAseq 0.9631 0.0032
SRP133303 ADORA2B 136 RNAseq 0.8848 0.0000
SRP159526 ADORA2B 136 RNAseq 0.9111 0.0366
SRP193095 ADORA2B 136 RNAseq 0.9791 0.0001
SRP219564 ADORA2B 136 RNAseq 1.1362 0.1283
TCGA ADORA2B 136 RNAseq 1.2731 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by ADORA2B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADORA2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADORA2B 136 3 4 23
GSE20123 ADORA2B 136 3 5 22
GSE43470 ADORA2B 136 2 5 36
GSE46452 ADORA2B 136 34 1 24
GSE47630 ADORA2B 136 7 1 32
GSE54993 ADORA2B 136 3 3 64
GSE54994 ADORA2B 136 6 5 42
GSE60625 ADORA2B 136 4 0 7
GSE74703 ADORA2B 136 2 2 32
GSE74704 ADORA2B 136 2 2 16
TCGA ADORA2B 136 18 22 56

Total number of gains: 84; Total number of losses: 50; Total Number of normals: 354.  

 

Somatic mutations of ADORA2B:

 

Generating mutation plots.

 

Highly correlated genes for ADORA2B:

 

Showing top 20/1405 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADORA2BPDE8A0.755529303
ADORA2BDKC10.730465303
ADORA2BSYT70.727215404
ADORA2BKREMEN10.719483303
ADORA2BMTFP10.713492404
ADORA2BBLACAT10.709936404
ADORA2BTMEM540.702048404
ADORA2BUCK20.699465303
ADORA2BCCDC860.693443808
ADORA2BANLN0.687481807
ADORA2BGSTCD0.684375303
ADORA2BCDCA20.680539605
ADORA2BCKAP2L0.680202707
ADORA2BCDH30.67967310010
ADORA2BPHTF10.678293303
ADORA2BPRTFDC10.677151303
ADORA2BMPHOSPH60.676381009
ADORA2BPBK0.6756611009
ADORA2BDEPDC1B0.674551606
ADORA2BCDCA40.67404312011

For details and further investigation, click here