GPX2

 

Full name: glutathione peroxidase 2 Alias Symbol: GSHPX-GI
Type: protein-coding gene Cytoband: 14q23.3
Entrez ID: 2877 HGNC ID: HGNC:4554 Ensembl Gene: ENSG00000176153 OMIM ID: 138319
Drug and gene relationship at DGIdb

 

Expression of GPX2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GPX2 2877 202831_at 0.6934 0.2599
GSE20347 GPX2 2877 202831_at 0.9906 0.0123
GSE23400 GPX2 2877 202831_at 0.9206 0.0001
GSE26886 GPX2 2877 202831_at 0.3142 0.6905
GSE29001 GPX2 2877 202831_at 0.3318 0.6851
GSE38129 GPX2 2877 202831_at 1.4345 0.0026
GSE45670 GPX2 2877 202831_at 1.1932 0.1268
GSE53622 GPX2 2877 130851 1.5953 0.0000
GSE53624 GPX2 2877 130851 0.8715 0.0000
GSE63941 GPX2 2877 202831_at 5.9119 0.0112
GSE77861 GPX2 2877 202831_at 1.5422 0.0700
GSE97050 GPX2 2877 A_23_P3038 1.5898 0.1678
SRP007169 GPX2 2877 RNAseq 2.1032 0.0006
SRP008496 GPX2 2877 RNAseq 1.8931 0.0001
SRP064894 GPX2 2877 RNAseq 1.1439 0.0643
SRP133303 GPX2 2877 RNAseq 1.0272 0.0131
SRP159526 GPX2 2877 RNAseq 2.5562 0.0039
SRP193095 GPX2 2877 RNAseq 0.6165 0.0829
SRP219564 GPX2 2877 RNAseq 1.4917 0.2547
TCGA GPX2 2877 RNAseq 0.1660 0.5342

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by GPX2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GPX2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GPX2 2877 7 3 20
GSE20123 GPX2 2877 7 3 20
GSE43470 GPX2 2877 8 2 33
GSE46452 GPX2 2877 16 3 40
GSE47630 GPX2 2877 11 9 20
GSE54993 GPX2 2877 3 9 58
GSE54994 GPX2 2877 18 5 30
GSE60625 GPX2 2877 0 2 9
GSE74703 GPX2 2877 7 2 27
GSE74704 GPX2 2877 3 2 15
TCGA GPX2 2877 32 14 50

Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.  

 

Somatic mutations of GPX2:

 

Generating mutation plots.

 

Highly correlated genes for GPX2:

 

Showing top 20/287 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GPX2AKR1C20.7233571009
GPX2KRT6B0.716412303
GPX2AKR1C10.70546411010
GPX2OSGIN10.695538808
GPX2DLX6-AS10.683413404
GPX2JAKMIP30.679776404
GPX2G6PD0.66807312011
GPX2SYNGR20.667423303
GPX2AKR1C30.66681513012
GPX2FAM83B0.650717404
GPX2TUBA4A0.646443303
GPX2GCLM0.645037908
GPX2SERPINB50.64479403
GPX2CYP2S10.643719807
GPX2AKR1C40.64200312010
GPX2SRXN10.641481505
GPX2KLRG20.634988303
GPX2TAPBPL0.632368303
GPX2COA60.630285705
GPX2SLC7A110.62953211010

For details and further investigation, click here