AKR1C4

 

Full name: aldo-keto reductase family 1 member C4 Alias Symbol: DD4|HAKRA|C11|3-alpha-HSD|CDR|MGC22581
Type: protein-coding gene Cytoband: 10p15.1
Entrez ID: 1109 HGNC ID: HGNC:387 Ensembl Gene: ENSG00000198610 OMIM ID: 600451
Drug and gene relationship at DGIdb

 

Expression of AKR1C4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AKR1C4 1109 210558_at 0.1086 0.7415
GSE20347 AKR1C4 1109 210558_at 0.1668 0.0520
GSE23400 AKR1C4 1109 210558_at 0.0153 0.6553
GSE26886 AKR1C4 1109 210558_at 0.0060 0.9674
GSE29001 AKR1C4 1109 210558_at 0.0752 0.4991
GSE38129 AKR1C4 1109 210558_at 0.1436 0.0679
GSE45670 AKR1C4 1109 210558_at 0.2803 0.0308
GSE53622 AKR1C4 1109 98605 0.8422 0.0198
GSE53624 AKR1C4 1109 98605 0.8953 0.0002
GSE63941 AKR1C4 1109 210558_at -0.0012 0.9982
GSE77861 AKR1C4 1109 210558_at 0.2841 0.2247
TCGA AKR1C4 1109 RNAseq 2.3127 0.0755

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by AKR1C4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AKR1C4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AKR1C4 1109 6 7 17
GSE20123 AKR1C4 1109 6 6 18
GSE43470 AKR1C4 1109 4 6 33
GSE46452 AKR1C4 1109 2 14 43
GSE47630 AKR1C4 1109 6 14 20
GSE54993 AKR1C4 1109 11 0 59
GSE54994 AKR1C4 1109 4 10 39
GSE60625 AKR1C4 1109 0 0 11
GSE74703 AKR1C4 1109 3 4 29
GSE74704 AKR1C4 1109 1 5 14
TCGA AKR1C4 1109 20 24 52

Total number of gains: 63; Total number of losses: 90; Total Number of normals: 335.  

 

Somatic mutations of AKR1C4:

 

Generating mutation plots.

 

Highly correlated genes for AKR1C4:

 

Showing top 20/53 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AKR1C4AKR1C10.75422311011
AKR1C4AKR1C20.7432610010
AKR1C4AKR1C30.73871612011
AKR1C4GPN10.652244303
AKR1C4SPRR2G0.647526303
AKR1C4GPX20.64200312010
AKR1C4AKR1B150.639033303
AKR1C4SLC4A1AP0.635099303
AKR1C4SRXN10.634452604
AKR1C4CYP4F110.6087171109
AKR1C4G6PD0.60819411010
AKR1C4SLC7A110.60771912012
AKR1C4GCLM0.6060311007
AKR1C4DGUOK0.600668303
AKR1C4TMX20.594843303
AKR1C4ST3GAL50.589315303
AKR1C4NEFL0.583518404
AKR1C4EN10.58171604
AKR1C4OSGIN10.5795931209
AKR1C4PIR0.5777471209

For details and further investigation, click here