| Full name: ADP ribosylation factor like GTPase 14 | Alias Symbol: FLJ22595 | ||
| Type: protein-coding gene | Cytoband: 3q25.33 | ||
| Entrez ID: 80117 | HGNC ID: HGNC:22974 | Ensembl Gene: ENSG00000179674 | OMIM ID: 614439 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ARL14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARL14 | 80117 | 220468_at | -0.1209 | 0.9513 | |
| GSE20347 | ARL14 | 80117 | 220468_at | -0.1317 | 0.6479 | |
| GSE23400 | ARL14 | 80117 | 220468_at | 0.0492 | 0.4939 | |
| GSE26886 | ARL14 | 80117 | 220468_at | 0.0882 | 0.8501 | |
| GSE29001 | ARL14 | 80117 | 220468_at | -0.8863 | 0.0663 | |
| GSE38129 | ARL14 | 80117 | 220468_at | -0.4069 | 0.1792 | |
| GSE45670 | ARL14 | 80117 | 220468_at | -0.1152 | 0.8541 | |
| GSE53622 | ARL14 | 80117 | 154096 | -0.8469 | 0.0053 | |
| GSE53624 | ARL14 | 80117 | 154096 | -1.5941 | 0.0000 | |
| GSE63941 | ARL14 | 80117 | 220468_at | 1.3194 | 0.2383 | |
| GSE77861 | ARL14 | 80117 | 220468_at | -0.2294 | 0.1121 | |
| SRP007169 | ARL14 | 80117 | RNAseq | -7.4234 | 0.0000 | |
| SRP064894 | ARL14 | 80117 | RNAseq | -2.0894 | 0.0000 | |
| SRP133303 | ARL14 | 80117 | RNAseq | 0.0452 | 0.9203 | |
| SRP159526 | ARL14 | 80117 | RNAseq | -3.5527 | 0.0000 | |
| SRP193095 | ARL14 | 80117 | RNAseq | -1.7321 | 0.0018 | |
| TCGA | ARL14 | 80117 | RNAseq | -1.7786 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ARL14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARL14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARL14 | 80117 | 22 | 0 | 8 | |
| GSE20123 | ARL14 | 80117 | 22 | 0 | 8 | |
| GSE43470 | ARL14 | 80117 | 23 | 0 | 20 | |
| GSE46452 | ARL14 | 80117 | 18 | 2 | 39 | |
| GSE47630 | ARL14 | 80117 | 19 | 3 | 18 | |
| GSE54993 | ARL14 | 80117 | 1 | 11 | 58 | |
| GSE54994 | ARL14 | 80117 | 38 | 1 | 14 | |
| GSE60625 | ARL14 | 80117 | 0 | 6 | 5 | |
| GSE74703 | ARL14 | 80117 | 20 | 0 | 16 | |
| GSE74704 | ARL14 | 80117 | 14 | 0 | 6 | |
| TCGA | ARL14 | 80117 | 77 | 0 | 19 |
Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.
Somatic mutations of ARL14:
Generating mutation plots.
Highly correlated genes for ARL14:
Showing top 20/101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARL14 | TLR1 | 0.668958 | 3 | 0 | 3 |
| ARL14 | MYL12B | 0.649914 | 4 | 0 | 3 |
| ARL14 | CAPZA1 | 0.626401 | 4 | 0 | 3 |
| ARL14 | AKR7A3 | 0.621549 | 3 | 0 | 3 |
| ARL14 | FAXDC2 | 0.607943 | 3 | 0 | 3 |
| ARL14 | TMEM171 | 0.603709 | 4 | 0 | 3 |
| ARL14 | PPP4R1 | 0.601889 | 7 | 0 | 4 |
| ARL14 | FER | 0.598973 | 5 | 0 | 4 |
| ARL14 | PFKFB2 | 0.593259 | 3 | 0 | 3 |
| ARL14 | TUBB6 | 0.592105 | 6 | 0 | 5 |
| ARL14 | SUCO | 0.59166 | 3 | 0 | 3 |
| ARL14 | AFAP1L2 | 0.591567 | 6 | 0 | 4 |
| ARL14 | CWH43 | 0.588915 | 6 | 0 | 4 |
| ARL14 | ATP6V1D | 0.586898 | 5 | 0 | 4 |
| ARL14 | RTCA | 0.574789 | 6 | 0 | 4 |
| ARL14 | AMFR | 0.573329 | 4 | 0 | 3 |
| ARL14 | SLC44A3 | 0.566762 | 5 | 0 | 4 |
| ARL14 | LAMTOR3 | 0.562615 | 3 | 0 | 3 |
| ARL14 | SLC6A11 | 0.560631 | 5 | 0 | 3 |
| ARL14 | BCL10 | 0.560344 | 6 | 0 | 5 |
For details and further investigation, click here
