| Full name: fyn related Src family tyrosine kinase | Alias Symbol: RAK|GTK | ||
| Type: protein-coding gene | Cytoband: 6q22.1 | ||
| Entrez ID: 2444 | HGNC ID: HGNC:3955 | Ensembl Gene: ENSG00000111816 | OMIM ID: 606573 |
| Related drugs: BOSUTINIB, DASATINIB, ENMD-981693, ILORASERTIB, NINTEDANIB, REGORAFENIB, TG100-801, XL-228... [more] | |||
Expression of FRK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FRK | 2444 | 235924_at | 0.3906 | 0.7709 | |
| GSE20347 | FRK | 2444 | 207178_s_at | -0.2529 | 0.1015 | |
| GSE23400 | FRK | 2444 | 207178_s_at | -0.0986 | 0.0151 | |
| GSE26886 | FRK | 2444 | 235924_at | -1.3076 | 0.0001 | |
| GSE29001 | FRK | 2444 | 207178_s_at | -0.2864 | 0.5852 | |
| GSE38129 | FRK | 2444 | 207178_s_at | -0.0399 | 0.8465 | |
| GSE45670 | FRK | 2444 | 235924_at | 0.1628 | 0.6172 | |
| GSE53622 | FRK | 2444 | 90485 | -0.3849 | 0.0362 | |
| GSE53624 | FRK | 2444 | 90485 | -0.8825 | 0.0000 | |
| GSE63941 | FRK | 2444 | 235924_at | 1.8799 | 0.0847 | |
| GSE77861 | FRK | 2444 | 235924_at | -0.3458 | 0.2685 | |
| GSE97050 | FRK | 2444 | A_23_P133665 | -0.3106 | 0.3399 | |
| SRP007169 | FRK | 2444 | RNAseq | 0.0821 | 0.8780 | |
| SRP008496 | FRK | 2444 | RNAseq | -0.1490 | 0.6402 | |
| SRP064894 | FRK | 2444 | RNAseq | -0.7725 | 0.0041 | |
| SRP133303 | FRK | 2444 | RNAseq | 0.0611 | 0.6995 | |
| SRP159526 | FRK | 2444 | RNAseq | -0.1465 | 0.6527 | |
| SRP193095 | FRK | 2444 | RNAseq | -0.0193 | 0.8714 | |
| SRP219564 | FRK | 2444 | RNAseq | -0.5146 | 0.4145 | |
| TCGA | FRK | 2444 | RNAseq | -0.2080 | 0.2108 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FRK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FRK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FRK | 2444 | 1 | 4 | 25 | |
| GSE20123 | FRK | 2444 | 1 | 3 | 26 | |
| GSE43470 | FRK | 2444 | 3 | 1 | 39 | |
| GSE46452 | FRK | 2444 | 2 | 11 | 46 | |
| GSE47630 | FRK | 2444 | 9 | 4 | 27 | |
| GSE54993 | FRK | 2444 | 3 | 2 | 65 | |
| GSE54994 | FRK | 2444 | 8 | 8 | 37 | |
| GSE60625 | FRK | 2444 | 0 | 2 | 9 | |
| GSE74703 | FRK | 2444 | 2 | 1 | 33 | |
| GSE74704 | FRK | 2444 | 0 | 1 | 19 | |
| TCGA | FRK | 2444 | 7 | 22 | 67 |
Total number of gains: 36; Total number of losses: 59; Total Number of normals: 393.
Somatic mutations of FRK:
Generating mutation plots.
Highly correlated genes for FRK:
Showing top 20/316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FRK | ASCC3 | 0.734758 | 3 | 0 | 3 |
| FRK | PIK3C3 | 0.663287 | 3 | 0 | 3 |
| FRK | SCIN | 0.643046 | 5 | 0 | 4 |
| FRK | SLC12A6 | 0.636783 | 7 | 0 | 6 |
| FRK | VPS26A | 0.628047 | 4 | 0 | 4 |
| FRK | SYK | 0.626667 | 6 | 0 | 5 |
| FRK | ANKRD13A | 0.615132 | 3 | 0 | 3 |
| FRK | CGGBP1 | 0.614841 | 4 | 0 | 4 |
| FRK | CDH1 | 0.610529 | 7 | 0 | 5 |
| FRK | SOX21-AS1 | 0.610449 | 5 | 0 | 4 |
| FRK | SMIM15 | 0.605019 | 3 | 0 | 3 |
| FRK | SIAE | 0.603108 | 5 | 0 | 4 |
| FRK | LIN54 | 0.600192 | 3 | 0 | 3 |
| FRK | STX19 | 0.599103 | 6 | 0 | 4 |
| FRK | STX18 | 0.593553 | 3 | 0 | 3 |
| FRK | ARNTL2 | 0.593003 | 7 | 0 | 7 |
| FRK | ANKRD22 | 0.591057 | 5 | 0 | 4 |
| FRK | AP1S3 | 0.586909 | 4 | 0 | 4 |
| FRK | IDE | 0.586265 | 5 | 0 | 4 |
| FRK | STAU2 | 0.58581 | 5 | 0 | 3 |
For details and further investigation, click here
