| Full name: FA complementation group I | Alias Symbol: FLJ10719 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 55215 | HGNC ID: HGNC:25568 | Ensembl Gene: ENSG00000140525 | OMIM ID: 611360 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCI involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCI | 55215 | 213007_at | 1.6283 | 0.0526 | |
| GSE20347 | FANCI | 55215 | 213007_at | 1.6322 | 0.0000 | |
| GSE23400 | FANCI | 55215 | 213007_at | 1.1379 | 0.0000 | |
| GSE26886 | FANCI | 55215 | 213007_at | 1.8727 | 0.0000 | |
| GSE29001 | FANCI | 55215 | 213007_at | 1.4900 | 0.0002 | |
| GSE38129 | FANCI | 55215 | 213007_at | 2.1168 | 0.0000 | |
| GSE45670 | FANCI | 55215 | 213007_at | 1.4016 | 0.0000 | |
| GSE53622 | FANCI | 55215 | 9680 | 1.5090 | 0.0000 | |
| GSE53624 | FANCI | 55215 | 9680 | 1.6184 | 0.0000 | |
| GSE63941 | FANCI | 55215 | 213007_at | 2.1900 | 0.0015 | |
| GSE77861 | FANCI | 55215 | 213007_at | 0.7921 | 0.0056 | |
| GSE97050 | FANCI | 55215 | A_32_P95729 | 1.0746 | 0.1204 | |
| SRP007169 | FANCI | 55215 | RNAseq | 1.5489 | 0.0007 | |
| SRP008496 | FANCI | 55215 | RNAseq | 1.2800 | 0.0003 | |
| SRP064894 | FANCI | 55215 | RNAseq | 1.3583 | 0.0000 | |
| SRP133303 | FANCI | 55215 | RNAseq | 1.2888 | 0.0002 | |
| SRP159526 | FANCI | 55215 | RNAseq | 1.7829 | 0.0000 | |
| SRP193095 | FANCI | 55215 | RNAseq | 1.0500 | 0.0000 | |
| SRP219564 | FANCI | 55215 | RNAseq | 1.4167 | 0.0128 | |
| TCGA | FANCI | 55215 | RNAseq | 0.6761 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by FANCI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCI | 55215 | 8 | 3 | 19 | |
| GSE20123 | FANCI | 55215 | 8 | 3 | 19 | |
| GSE43470 | FANCI | 55215 | 5 | 4 | 34 | |
| GSE46452 | FANCI | 55215 | 3 | 7 | 49 | |
| GSE47630 | FANCI | 55215 | 8 | 11 | 21 | |
| GSE54993 | FANCI | 55215 | 4 | 6 | 60 | |
| GSE54994 | FANCI | 55215 | 7 | 6 | 40 | |
| GSE60625 | FANCI | 55215 | 4 | 0 | 7 | |
| GSE74703 | FANCI | 55215 | 4 | 3 | 29 | |
| GSE74704 | FANCI | 55215 | 4 | 2 | 14 | |
| TCGA | FANCI | 55215 | 17 | 12 | 67 |
Total number of gains: 72; Total number of losses: 57; Total Number of normals: 359.
Somatic mutations of FANCI:
Generating mutation plots.
Highly correlated genes for FANCI:
Showing top 20/1886 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCI | PRC1 | 0.852139 | 13 | 0 | 13 |
| FANCI | BLM | 0.851018 | 13 | 0 | 13 |
| FANCI | GINS1 | 0.837951 | 12 | 0 | 12 |
| FANCI | KIF4A | 0.832681 | 11 | 0 | 11 |
| FANCI | CENPF | 0.8217 | 13 | 0 | 12 |
| FANCI | RAD51 | 0.821182 | 11 | 0 | 11 |
| FANCI | TRIP13 | 0.820078 | 13 | 0 | 12 |
| FANCI | KNSTRN | 0.816885 | 7 | 0 | 7 |
| FANCI | DTL | 0.816666 | 13 | 0 | 12 |
| FANCI | CKS1B | 0.81063 | 12 | 0 | 12 |
| FANCI | KIF20A | 0.809395 | 12 | 0 | 12 |
| FANCI | NUF2 | 0.80794 | 9 | 0 | 9 |
| FANCI | ORC6 | 0.807534 | 11 | 0 | 11 |
| FANCI | NCAPH | 0.80634 | 9 | 0 | 9 |
| FANCI | TACC3 | 0.806302 | 12 | 0 | 12 |
| FANCI | NUSAP1 | 0.805856 | 13 | 0 | 13 |
| FANCI | TOP2A | 0.805343 | 13 | 0 | 12 |
| FANCI | BUB1B | 0.804936 | 10 | 0 | 9 |
| FANCI | NEK2 | 0.802113 | 13 | 0 | 12 |
| FANCI | TPX2 | 0.801439 | 13 | 0 | 12 |
For details and further investigation, click here
