| Full name: kinesin family member 18A | Alias Symbol: DKFZP434G2226|PPP1R99 | ||
| Type: protein-coding gene | Cytoband: 11p14.1 | ||
| Entrez ID: 81930 | HGNC ID: HGNC:29441 | Ensembl Gene: ENSG00000121621 | OMIM ID: 611271 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KIF18A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF18A | 81930 | 221258_s_at | 1.5365 | 0.0155 | |
| GSE20347 | KIF18A | 81930 | 221258_s_at | 1.0613 | 0.0000 | |
| GSE23400 | KIF18A | 81930 | 221258_s_at | 0.4896 | 0.0000 | |
| GSE26886 | KIF18A | 81930 | 221258_s_at | 0.8903 | 0.0117 | |
| GSE29001 | KIF18A | 81930 | 221258_s_at | 1.1103 | 0.0134 | |
| GSE38129 | KIF18A | 81930 | 221258_s_at | 1.4917 | 0.0000 | |
| GSE45670 | KIF18A | 81930 | 221258_s_at | 1.7189 | 0.0000 | |
| GSE53622 | KIF18A | 81930 | 148910 | 1.8527 | 0.0000 | |
| GSE53624 | KIF18A | 81930 | 148910 | 1.8338 | 0.0000 | |
| GSE63941 | KIF18A | 81930 | 221258_s_at | 1.6777 | 0.0194 | |
| GSE77861 | KIF18A | 81930 | 221258_s_at | 0.7402 | 0.0262 | |
| GSE97050 | KIF18A | 81930 | A_33_P3242649 | 0.4971 | 0.1049 | |
| SRP007169 | KIF18A | 81930 | RNAseq | 3.2713 | 0.0000 | |
| SRP008496 | KIF18A | 81930 | RNAseq | 3.3221 | 0.0000 | |
| SRP133303 | KIF18A | 81930 | RNAseq | 2.2881 | 0.0000 | |
| SRP159526 | KIF18A | 81930 | RNAseq | 1.2546 | 0.0003 | |
| SRP193095 | KIF18A | 81930 | RNAseq | 1.1478 | 0.0000 | |
| SRP219564 | KIF18A | 81930 | RNAseq | 1.4055 | 0.0226 | |
| TCGA | KIF18A | 81930 | RNAseq | 1.3776 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by KIF18A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF18A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF18A | 81930 | 1 | 9 | 20 | |
| GSE20123 | KIF18A | 81930 | 1 | 8 | 21 | |
| GSE43470 | KIF18A | 81930 | 1 | 6 | 36 | |
| GSE46452 | KIF18A | 81930 | 6 | 6 | 47 | |
| GSE47630 | KIF18A | 81930 | 3 | 10 | 27 | |
| GSE54993 | KIF18A | 81930 | 3 | 0 | 67 | |
| GSE54994 | KIF18A | 81930 | 4 | 11 | 38 | |
| GSE60625 | KIF18A | 81930 | 0 | 0 | 11 | |
| GSE74703 | KIF18A | 81930 | 1 | 4 | 31 | |
| GSE74704 | KIF18A | 81930 | 0 | 8 | 12 | |
| TCGA | KIF18A | 81930 | 10 | 25 | 61 |
Total number of gains: 30; Total number of losses: 87; Total Number of normals: 371.
Somatic mutations of KIF18A:
Generating mutation plots.
Highly correlated genes for KIF18A:
Showing top 20/1962 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF18A | BUB1 | 0.845865 | 11 | 0 | 11 |
| KIF18A | MMS22L | 0.80926 | 3 | 0 | 3 |
| KIF18A | ASPM | 0.803248 | 13 | 0 | 13 |
| KIF18A | RAD51AP1 | 0.800624 | 12 | 0 | 12 |
| KIF18A | UCK2 | 0.799657 | 3 | 0 | 3 |
| KIF18A | CDCA2 | 0.796548 | 7 | 0 | 6 |
| KIF18A | DLGAP5 | 0.794284 | 12 | 0 | 11 |
| KIF18A | KIF15 | 0.785837 | 12 | 0 | 11 |
| KIF18A | MND1 | 0.785798 | 9 | 0 | 8 |
| KIF18A | CCNB2 | 0.78509 | 12 | 0 | 11 |
| KIF18A | ATAD2 | 0.784284 | 13 | 0 | 12 |
| KIF18A | NUF2 | 0.784115 | 9 | 0 | 8 |
| KIF18A | NCAPG2 | 0.78367 | 11 | 0 | 11 |
| KIF18A | HMMR | 0.78319 | 12 | 0 | 12 |
| KIF18A | MCM6 | 0.782589 | 13 | 0 | 12 |
| KIF18A | CENPE | 0.782193 | 13 | 0 | 12 |
| KIF18A | CDCA3 | 0.78126 | 13 | 0 | 12 |
| KIF18A | CDKN3 | 0.781118 | 13 | 0 | 12 |
| KIF18A | BORA | 0.780583 | 10 | 0 | 10 |
| KIF18A | CENPN | 0.776815 | 12 | 0 | 12 |
For details and further investigation, click here
