| Full name: distal-less homeobox 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 1747 | HGNC ID: HGNC:2916 | Ensembl Gene: ENSG00000064195 | OMIM ID: 600525 |
| Drug and gene relationship at DGIdb | |||
Expression of DLX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLX3 | 1747 | 231778_at | 1.0721 | 0.1306 | |
| GSE26886 | DLX3 | 1747 | 231778_at | -0.2059 | 0.1315 | |
| GSE45670 | DLX3 | 1747 | 231778_at | 0.3464 | 0.0976 | |
| GSE63941 | DLX3 | 1747 | 231778_at | 0.6221 | 0.1627 | |
| GSE77861 | DLX3 | 1747 | 231778_at | 0.1163 | 0.5198 | |
| GSE97050 | DLX3 | 1747 | A_24_P296587 | 0.3285 | 0.3207 | |
| SRP007169 | DLX3 | 1747 | RNAseq | -2.3894 | 0.0117 | |
| SRP133303 | DLX3 | 1747 | RNAseq | 0.8937 | 0.0981 | |
| SRP159526 | DLX3 | 1747 | RNAseq | 1.2804 | 0.0011 | |
| TCGA | DLX3 | 1747 | RNAseq | 1.1074 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by DLX3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DLX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLX3 | 1747 | 5 | 2 | 23 | |
| GSE20123 | DLX3 | 1747 | 5 | 2 | 23 | |
| GSE43470 | DLX3 | 1747 | 3 | 2 | 38 | |
| GSE46452 | DLX3 | 1747 | 32 | 0 | 27 | |
| GSE47630 | DLX3 | 1747 | 9 | 0 | 31 | |
| GSE54993 | DLX3 | 1747 | 2 | 4 | 64 | |
| GSE54994 | DLX3 | 1747 | 9 | 6 | 38 | |
| GSE60625 | DLX3 | 1747 | 4 | 0 | 7 | |
| GSE74703 | DLX3 | 1747 | 3 | 2 | 31 | |
| GSE74704 | DLX3 | 1747 | 4 | 1 | 15 | |
| TCGA | DLX3 | 1747 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of DLX3:
Generating mutation plots.
Highly correlated genes for DLX3:
Showing top 20/44 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLX3 | NOS1AP | 0.7093 | 3 | 0 | 3 |
| DLX3 | RABGEF1 | 0.706624 | 3 | 0 | 3 |
| DLX3 | DNAAF3 | 0.68977 | 3 | 0 | 3 |
| DLX3 | CDKN2AIPNL | 0.652368 | 3 | 0 | 3 |
| DLX3 | BMP7 | 0.648048 | 3 | 0 | 3 |
| DLX3 | DLX4 | 0.638326 | 4 | 0 | 3 |
| DLX3 | KRT75 | 0.628877 | 4 | 0 | 3 |
| DLX3 | KRT16 | 0.628589 | 4 | 0 | 3 |
| DLX3 | KRT6B | 0.619648 | 3 | 0 | 3 |
| DLX3 | ZNF488 | 0.618658 | 3 | 0 | 3 |
| DLX3 | SPRR2G | 0.618506 | 5 | 0 | 4 |
| DLX3 | HOXC10 | 0.614441 | 4 | 0 | 4 |
| DLX3 | NXPH4 | 0.612147 | 5 | 0 | 4 |
| DLX3 | CABLES2 | 0.607903 | 5 | 0 | 3 |
| DLX3 | YKT6 | 0.60281 | 3 | 0 | 3 |
| DLX3 | ELMO3 | 0.592599 | 3 | 0 | 3 |
| DLX3 | WFDC5 | 0.587871 | 6 | 0 | 3 |
| DLX3 | ABCA12 | 0.585842 | 4 | 0 | 3 |
| DLX3 | CEACAM19 | 0.584556 | 5 | 0 | 3 |
| DLX3 | ALOXE3 | 0.584426 | 6 | 0 | 4 |
For details and further investigation, click here
