SERPING1

 

Full name: serpin family G member 1 Alias Symbol: C1IN|C1-INH|HAE1|HAE2|C1INH
Type: protein-coding gene Cytoband: 11q12.1
Entrez ID: 710 HGNC ID: HGNC:1228 Ensembl Gene: ENSG00000149131 OMIM ID: 606860
Drug and gene relationship at DGIdb

 

SERPING1 involved pathways:

KEGG pathway Description View
hsa04610Complement and coagulation cascades
hsa05133Pertussis

 

Expression of SERPING1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SERPING1 710 200986_at -0.3432 0.7651
GSE20347 SERPING1 710 200986_at 0.8836 0.0042
GSE23400 SERPING1 710 200986_at 0.2507 0.1915
GSE26886 SERPING1 710 200986_at 1.2674 0.0231
GSE29001 SERPING1 710 200986_at 1.0791 0.0143
GSE38129 SERPING1 710 200986_at 0.2727 0.6138
GSE45670 SERPING1 710 200986_at -0.9823 0.0273
GSE53622 SERPING1 710 105046 0.2549 0.0628
GSE53624 SERPING1 710 105046 0.4173 0.0000
GSE63941 SERPING1 710 200986_at -4.2862 0.0000
GSE77861 SERPING1 710 200986_at 0.5087 0.1516
GSE97050 SERPING1 710 A_33_P3413989 0.3279 0.4168
SRP007169 SERPING1 710 RNAseq 4.2629 0.0000
SRP008496 SERPING1 710 RNAseq 4.5991 0.0000
SRP064894 SERPING1 710 RNAseq 0.6132 0.1245
SRP133303 SERPING1 710 RNAseq 0.0464 0.8740
SRP159526 SERPING1 710 RNAseq 0.1372 0.8105
SRP193095 SERPING1 710 RNAseq 1.4891 0.0000
SRP219564 SERPING1 710 RNAseq 0.7181 0.2877
TCGA SERPING1 710 RNAseq -0.0931 0.3223

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by SERPING1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SERPING1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SERPING1 710 2 3 25
GSE20123 SERPING1 710 2 3 25
GSE43470 SERPING1 710 1 5 37
GSE46452 SERPING1 710 9 4 46
GSE47630 SERPING1 710 3 8 29
GSE54993 SERPING1 710 3 0 67
GSE54994 SERPING1 710 5 6 42
GSE60625 SERPING1 710 0 3 8
GSE74703 SERPING1 710 1 3 32
GSE74704 SERPING1 710 2 3 15
TCGA SERPING1 710 14 10 72

Total number of gains: 42; Total number of losses: 48; Total Number of normals: 398.  

 

Somatic mutations of SERPING1:

 

Generating mutation plots.

 

Highly correlated genes for SERPING1:

 

Showing top 20/905 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SERPING1C1S0.74104513012
SERPING1C1R0.73211513011
SERPING1AEBP10.70635913012
SERPING1OLFML30.70439513013
SERPING1PMP220.69933312011
SERPING1COL6A20.6854912010
SERPING1C1orf540.68054613010
SERPING1MMP20.6794811009
SERPING1TMEM1400.67884213011
SERPING1CTSK0.67773213012
SERPING1TMEM229B0.676806303
SERPING1C1QA0.67542611011
SERPING1C11orf960.673332505
SERPING1MDGA10.67195303
SERPING1GLIPR20.671033908
SERPING1C1QB0.67088511011
SERPING1TGM20.66838312011
SERPING1FBN10.6676491109
SERPING1RFTN10.66746113010
SERPING1CNTNAP10.666983404

For details and further investigation, click here