| Full name: calcium voltage-gated channel auxiliary subunit alpha2delta 3 | Alias Symbol: HSA272268 | ||
| Type: protein-coding gene | Cytoband: 3p21.1-p14.3 | ||
| Entrez ID: 55799 | HGNC ID: HGNC:15460 | Ensembl Gene: ENSG00000157445 | OMIM ID: 606399 |
| Drug and gene relationship at DGIdb | |||
CACNA2D3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNA2D3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA2D3 | 55799 | 219714_s_at | 0.1301 | 0.9246 | |
| GSE20347 | CACNA2D3 | 55799 | 219714_s_at | 0.0562 | 0.7831 | |
| GSE23400 | CACNA2D3 | 55799 | 219714_s_at | 0.0002 | 0.9966 | |
| GSE26886 | CACNA2D3 | 55799 | 219714_s_at | 0.3013 | 0.5049 | |
| GSE29001 | CACNA2D3 | 55799 | 219714_s_at | -0.6586 | 0.0690 | |
| GSE38129 | CACNA2D3 | 55799 | 219714_s_at | 0.1975 | 0.2347 | |
| GSE45670 | CACNA2D3 | 55799 | 219714_s_at | 0.3246 | 0.3099 | |
| GSE53622 | CACNA2D3 | 55799 | 39302 | -1.2250 | 0.0000 | |
| GSE53624 | CACNA2D3 | 55799 | 39302 | -1.6361 | 0.0000 | |
| GSE63941 | CACNA2D3 | 55799 | 219714_s_at | 0.1840 | 0.8918 | |
| GSE77861 | CACNA2D3 | 55799 | 219714_s_at | 0.2948 | 0.0972 | |
| GSE97050 | CACNA2D3 | 55799 | A_33_P3373259 | -0.5753 | 0.4046 | |
| SRP007169 | CACNA2D3 | 55799 | RNAseq | 0.8712 | 0.2074 | |
| SRP064894 | CACNA2D3 | 55799 | RNAseq | 0.1822 | 0.6425 | |
| SRP133303 | CACNA2D3 | 55799 | RNAseq | -1.2539 | 0.0003 | |
| SRP159526 | CACNA2D3 | 55799 | RNAseq | 0.3387 | 0.4693 | |
| SRP193095 | CACNA2D3 | 55799 | RNAseq | 0.2324 | 0.4638 | |
| SRP219564 | CACNA2D3 | 55799 | RNAseq | -0.7829 | 0.1786 | |
| TCGA | CACNA2D3 | 55799 | RNAseq | -0.2538 | 0.3542 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CACNA2D3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA2D3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA2D3 | 55799 | 0 | 17 | 13 | |
| GSE20123 | CACNA2D3 | 55799 | 0 | 18 | 12 | |
| GSE43470 | CACNA2D3 | 55799 | 0 | 17 | 26 | |
| GSE46452 | CACNA2D3 | 55799 | 2 | 18 | 39 | |
| GSE47630 | CACNA2D3 | 55799 | 1 | 24 | 15 | |
| GSE54993 | CACNA2D3 | 55799 | 6 | 2 | 62 | |
| GSE54994 | CACNA2D3 | 55799 | 0 | 32 | 21 | |
| GSE60625 | CACNA2D3 | 55799 | 5 | 0 | 6 | |
| GSE74703 | CACNA2D3 | 55799 | 0 | 14 | 22 | |
| GSE74704 | CACNA2D3 | 55799 | 0 | 12 | 8 | |
| TCGA | CACNA2D3 | 55799 | 0 | 82 | 14 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of CACNA2D3:
Generating mutation plots.
Highly correlated genes for CACNA2D3:
Showing all 20 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA2D3 | OTX2-AS1 | 0.609776 | 3 | 0 | 3 |
| CACNA2D3 | NDRG2 | 0.592919 | 4 | 0 | 4 |
| CACNA2D3 | FLAD1 | 0.587809 | 3 | 0 | 3 |
| CACNA2D3 | SLC26A9 | 0.581455 | 4 | 0 | 3 |
| CACNA2D3 | ABCA13 | 0.572506 | 4 | 0 | 3 |
| CACNA2D3 | POLR2F | 0.556672 | 3 | 0 | 3 |
| CACNA2D3 | ZC3H7A | 0.550804 | 3 | 0 | 3 |
| CACNA2D3 | MAGI1 | 0.538773 | 4 | 0 | 3 |
| CACNA2D3 | SUSD4 | 0.535184 | 6 | 0 | 4 |
| CACNA2D3 | KLKB1 | 0.53161 | 4 | 0 | 4 |
| CACNA2D3 | MYZAP | 0.530263 | 3 | 0 | 3 |
| CACNA2D3 | MPPED1 | 0.528546 | 4 | 0 | 3 |
| CACNA2D3 | JAKMIP3 | 0.525632 | 5 | 0 | 3 |
| CACNA2D3 | AKR1C1 | 0.521744 | 5 | 0 | 3 |
| CACNA2D3 | AKR1C2 | 0.52152 | 5 | 0 | 3 |
| CACNA2D3 | RAPGEF5 | 0.519665 | 7 | 0 | 3 |
| CACNA2D3 | KHDRBS3 | 0.518762 | 5 | 0 | 3 |
| CACNA2D3 | ANK3 | 0.510086 | 6 | 0 | 3 |
| CACNA2D3 | GSTM1 | 0.509285 | 6 | 0 | 3 |
| CACNA2D3 | TRIM2 | 0.501006 | 5 | 0 | 3 |
For details and further investigation, click here
