TNFAIP3

 

Full name: TNF alpha induced protein 3 Alias Symbol: A20|OTUD7C
Type: protein-coding gene Cytoband: 6q23.3
Entrez ID: 7128 HGNC ID: HGNC:11896 Ensembl Gene: ENSG00000118503 OMIM ID: 191163
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TNFAIP3 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05162Measles

 

Expression of TNFAIP3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TNFAIP3 7128 202644_s_at 0.1851 0.8852
GSE20347 TNFAIP3 7128 202644_s_at 0.9772 0.0013
GSE23400 TNFAIP3 7128 202644_s_at 0.8654 0.0000
GSE26886 TNFAIP3 7128 202644_s_at 1.2493 0.0107
GSE29001 TNFAIP3 7128 202644_s_at 1.0339 0.0049
GSE38129 TNFAIP3 7128 202644_s_at 0.7326 0.0100
GSE45670 TNFAIP3 7128 202644_s_at 0.6068 0.0970
GSE53622 TNFAIP3 7128 19466 1.4534 0.0000
GSE53624 TNFAIP3 7128 19466 1.0963 0.0000
GSE63941 TNFAIP3 7128 202644_s_at 0.3837 0.7517
GSE77861 TNFAIP3 7128 202644_s_at 1.4628 0.0121
GSE97050 TNFAIP3 7128 A_24_P157926 0.9878 0.0750
SRP007169 TNFAIP3 7128 RNAseq 0.8981 0.1328
SRP008496 TNFAIP3 7128 RNAseq 0.6447 0.1098
SRP064894 TNFAIP3 7128 RNAseq 1.0806 0.0032
SRP133303 TNFAIP3 7128 RNAseq 1.4925 0.0001
SRP159526 TNFAIP3 7128 RNAseq 1.2046 0.0145
SRP193095 TNFAIP3 7128 RNAseq 1.6816 0.0000
SRP219564 TNFAIP3 7128 RNAseq 2.0990 0.0029
TCGA TNFAIP3 7128 RNAseq 0.3867 0.0001

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by TNFAIP3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TNFAIP3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TNFAIP3 7128 3 4 23
GSE20123 TNFAIP3 7128 3 3 24
GSE43470 TNFAIP3 7128 5 0 38
GSE46452 TNFAIP3 7128 3 10 46
GSE47630 TNFAIP3 7128 9 4 27
GSE54993 TNFAIP3 7128 3 2 65
GSE54994 TNFAIP3 7128 8 8 37
GSE60625 TNFAIP3 7128 0 1 10
GSE74703 TNFAIP3 7128 4 0 32
GSE74704 TNFAIP3 7128 1 1 18
TCGA TNFAIP3 7128 11 17 68

Total number of gains: 50; Total number of losses: 50; Total Number of normals: 388.  

 

Somatic mutations of TNFAIP3:

 

Generating mutation plots.

 

Highly correlated genes for TNFAIP3:

 

Showing top 20/1183 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TNFAIP3C9orf640.719677303
TNFAIP3GTF2H30.70944303
TNFAIP3MAD2L20.708431505
TNFAIP3TNFRSF10B0.70658411011
TNFAIP3DDX590.705579303
TNFAIP3NFKB10.704603303
TNFAIP3CDCA20.697967403
TNFAIP3RAB340.697279303
TNFAIP3GNS0.695588404
TNFAIP3PDE7A0.695106706
TNFAIP3ZNF2750.694125404
TNFAIP3FADS10.693962303
TNFAIP3CEBPB0.6918612011
TNFAIP3GPR1530.691291404
TNFAIP3CPT1A0.691076303
TNFAIP3SLC39A100.690735403
TNFAIP3MTBP0.686085303
TNFAIP3GLB1L0.684689303
TNFAIP3PRTFDC10.682423505
TNFAIP3SGTB0.682079303

For details and further investigation, click here