| Full name: matrix metallopeptidase 10 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4319 | HGNC ID: HGNC:7156 | Ensembl Gene: ENSG00000166670 | OMIM ID: 185260 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP10 | 4319 | 205680_at | 3.2821 | 0.0036 | |
| GSE20347 | MMP10 | 4319 | 205680_at | 3.2548 | 0.0000 | |
| GSE23400 | MMP10 | 4319 | 205680_at | 2.1597 | 0.0000 | |
| GSE26886 | MMP10 | 4319 | 205680_at | 4.4924 | 0.0003 | |
| GSE29001 | MMP10 | 4319 | 205680_at | 1.8573 | 0.0463 | |
| GSE38129 | MMP10 | 4319 | 205680_at | 3.0915 | 0.0000 | |
| GSE45670 | MMP10 | 4319 | 205680_at | 5.2492 | 0.0000 | |
| GSE53622 | MMP10 | 4319 | 18968 | 3.5758 | 0.0000 | |
| GSE53624 | MMP10 | 4319 | 18968 | 4.5805 | 0.0000 | |
| GSE63941 | MMP10 | 4319 | 205680_at | -1.4132 | 0.5720 | |
| GSE77861 | MMP10 | 4319 | 205680_at | 2.4171 | 0.0138 | |
| GSE97050 | MMP10 | 4319 | A_23_P13094 | 1.5144 | 0.1581 | |
| SRP007169 | MMP10 | 4319 | RNAseq | 7.9986 | 0.0000 | |
| SRP008496 | MMP10 | 4319 | RNAseq | 9.5609 | 0.0000 | |
| SRP133303 | MMP10 | 4319 | RNAseq | 7.2916 | 0.0000 | |
| SRP159526 | MMP10 | 4319 | RNAseq | 5.9048 | 0.0000 | |
| SRP219564 | MMP10 | 4319 | RNAseq | 10.2621 | 0.0000 | |
| TCGA | MMP10 | 4319 | RNAseq | 2.6681 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by MMP10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP10 | 4319 | 5 | 8 | 17 | |
| GSE20123 | MMP10 | 4319 | 5 | 8 | 17 | |
| GSE43470 | MMP10 | 4319 | 5 | 5 | 33 | |
| GSE46452 | MMP10 | 4319 | 5 | 24 | 30 | |
| GSE47630 | MMP10 | 4319 | 2 | 19 | 19 | |
| GSE54993 | MMP10 | 4319 | 9 | 2 | 59 | |
| GSE54994 | MMP10 | 4319 | 6 | 18 | 29 | |
| GSE60625 | MMP10 | 4319 | 0 | 3 | 8 | |
| GSE74703 | MMP10 | 4319 | 3 | 4 | 29 | |
| GSE74704 | MMP10 | 4319 | 5 | 4 | 11 | |
| TCGA | MMP10 | 4319 | 10 | 44 | 42 |
Total number of gains: 55; Total number of losses: 139; Total Number of normals: 294.
Somatic mutations of MMP10:
Generating mutation plots.
Highly correlated genes for MMP10:
Showing top 20/1448 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP10 | CD276 | 0.800405 | 5 | 0 | 5 |
| MMP10 | MMP1 | 0.768233 | 13 | 0 | 13 |
| MMP10 | CTHRC1 | 0.75446 | 7 | 0 | 7 |
| MMP10 | TNFAIP8L1 | 0.74725 | 4 | 0 | 4 |
| MMP10 | WDR66 | 0.746999 | 7 | 0 | 7 |
| MMP10 | CDCA2 | 0.740851 | 5 | 0 | 5 |
| MMP10 | PLAU | 0.732386 | 12 | 0 | 12 |
| MMP10 | TPX2 | 0.720826 | 10 | 0 | 10 |
| MMP10 | MMP13 | 0.720477 | 12 | 0 | 11 |
| MMP10 | UBE2T | 0.717324 | 7 | 0 | 6 |
| MMP10 | GPR85 | 0.716892 | 3 | 0 | 3 |
| MMP10 | LAMC2 | 0.716103 | 12 | 0 | 11 |
| MMP10 | MFAP2 | 0.715684 | 11 | 0 | 10 |
| MMP10 | ZCCHC3 | 0.708322 | 3 | 0 | 3 |
| MMP10 | HOXC9 | 0.707753 | 4 | 0 | 4 |
| MMP10 | INHBA | 0.70601 | 10 | 0 | 10 |
| MMP10 | KIF4A | 0.705965 | 9 | 0 | 9 |
| MMP10 | SERPINH1 | 0.705428 | 10 | 0 | 9 |
| MMP10 | CDCA5 | 0.69894 | 6 | 0 | 5 |
| MMP10 | DNMT3B | 0.696427 | 9 | 0 | 8 |
For details and further investigation, click here
