| Full name: neural EGFL like 2 | Alias Symbol: NRP2 | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 4753 | HGNC ID: HGNC:7751 | Ensembl Gene: ENSG00000184613 | OMIM ID: 602320 |
| Drug and gene relationship at DGIdb | |||
Expression of NELL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NELL2 | 4753 | 203413_at | 3.2890 | 0.0123 | |
| GSE20347 | NELL2 | 4753 | 203413_at | 2.0892 | 0.0000 | |
| GSE23400 | NELL2 | 4753 | 203413_at | 1.2544 | 0.0000 | |
| GSE26886 | NELL2 | 4753 | 203413_at | 3.0812 | 0.0001 | |
| GSE29001 | NELL2 | 4753 | 203413_at | 2.6957 | 0.0003 | |
| GSE38129 | NELL2 | 4753 | 203413_at | 2.3055 | 0.0000 | |
| GSE45670 | NELL2 | 4753 | 203413_at | 2.2456 | 0.0001 | |
| GSE53622 | NELL2 | 4753 | 26715 | 3.3447 | 0.0000 | |
| GSE53624 | NELL2 | 4753 | 26715 | 3.1580 | 0.0000 | |
| GSE63941 | NELL2 | 4753 | 203413_at | 2.1565 | 0.1179 | |
| GSE77861 | NELL2 | 4753 | 203413_at | 2.8385 | 0.0016 | |
| GSE97050 | NELL2 | 4753 | A_23_P10025 | 1.5318 | 0.1131 | |
| SRP007169 | NELL2 | 4753 | RNAseq | 5.1287 | 0.0000 | |
| SRP008496 | NELL2 | 4753 | RNAseq | 4.6816 | 0.0000 | |
| SRP064894 | NELL2 | 4753 | RNAseq | 2.9122 | 0.0000 | |
| SRP133303 | NELL2 | 4753 | RNAseq | 3.6079 | 0.0000 | |
| SRP159526 | NELL2 | 4753 | RNAseq | 3.0850 | 0.0000 | |
| SRP193095 | NELL2 | 4753 | RNAseq | 3.1347 | 0.0000 | |
| SRP219564 | NELL2 | 4753 | RNAseq | 2.5430 | 0.0054 | |
| TCGA | NELL2 | 4753 | RNAseq | 0.7741 | 0.0034 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by NELL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NELL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NELL2 | 4753 | 6 | 1 | 23 | |
| GSE20123 | NELL2 | 4753 | 6 | 1 | 23 | |
| GSE43470 | NELL2 | 4753 | 3 | 1 | 39 | |
| GSE46452 | NELL2 | 4753 | 8 | 1 | 50 | |
| GSE47630 | NELL2 | 4753 | 11 | 2 | 27 | |
| GSE54993 | NELL2 | 4753 | 0 | 6 | 64 | |
| GSE54994 | NELL2 | 4753 | 7 | 1 | 45 | |
| GSE60625 | NELL2 | 4753 | 0 | 0 | 11 | |
| GSE74703 | NELL2 | 4753 | 3 | 1 | 32 | |
| GSE74704 | NELL2 | 4753 | 3 | 1 | 16 | |
| TCGA | NELL2 | 4753 | 15 | 13 | 68 |
Total number of gains: 62; Total number of losses: 28; Total Number of normals: 398.
Somatic mutations of NELL2:
Generating mutation plots.
Highly correlated genes for NELL2:
Showing top 20/1531 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NELL2 | CD276 | 0.805883 | 4 | 0 | 4 |
| NELL2 | HOXC9 | 0.75552 | 4 | 0 | 4 |
| NELL2 | CTHRC1 | 0.750985 | 7 | 0 | 7 |
| NELL2 | LAMC2 | 0.749232 | 11 | 0 | 11 |
| NELL2 | XPR1 | 0.745695 | 7 | 0 | 7 |
| NELL2 | MFAP2 | 0.735363 | 11 | 0 | 11 |
| NELL2 | MMP1 | 0.728122 | 11 | 0 | 11 |
| NELL2 | CDCA2 | 0.726503 | 5 | 0 | 4 |
| NELL2 | COL12A1 | 0.723991 | 4 | 0 | 4 |
| NELL2 | KIF14 | 0.717407 | 11 | 0 | 11 |
| NELL2 | WDR66 | 0.715885 | 8 | 0 | 7 |
| NELL2 | NOP56 | 0.711794 | 3 | 0 | 3 |
| NELL2 | FSCN1 | 0.710029 | 12 | 0 | 11 |
| NELL2 | SPAG5 | 0.708206 | 10 | 0 | 9 |
| NELL2 | ACLY | 0.708179 | 11 | 0 | 10 |
| NELL2 | UHRF1 | 0.707986 | 7 | 0 | 7 |
| NELL2 | STC2 | 0.705786 | 9 | 0 | 9 |
| NELL2 | BUB1 | 0.704964 | 9 | 0 | 9 |
| NELL2 | COL5A2 | 0.702498 | 11 | 0 | 10 |
| NELL2 | EME1 | 0.701471 | 5 | 0 | 4 |
For details and further investigation, click here
