| Full name: CD58 molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p13.1 | ||
| Entrez ID: 965 | HGNC ID: HGNC:1688 | Ensembl Gene: ENSG00000116815 | OMIM ID: 153420 |
| Drug and gene relationship at DGIdb | |||
Expression of CD58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD58 | 965 | 205173_x_at | -0.5125 | 0.3548 | |
| GSE20347 | CD58 | 965 | 205173_x_at | -0.1434 | 0.5101 | |
| GSE23400 | CD58 | 965 | 205173_x_at | 0.5386 | 0.0000 | |
| GSE26886 | CD58 | 965 | 205173_x_at | 0.2203 | 0.4925 | |
| GSE29001 | CD58 | 965 | 205173_x_at | 0.0699 | 0.9297 | |
| GSE38129 | CD58 | 965 | 205173_x_at | 0.0673 | 0.7515 | |
| GSE45670 | CD58 | 965 | 205173_x_at | 0.2034 | 0.1945 | |
| GSE53622 | CD58 | 965 | 80296 | 0.2223 | 0.0362 | |
| GSE53624 | CD58 | 965 | 21537 | 0.1813 | 0.0303 | |
| GSE63941 | CD58 | 965 | 205173_x_at | 2.3818 | 0.0011 | |
| GSE77861 | CD58 | 965 | 205173_x_at | -0.1019 | 0.8374 | |
| GSE97050 | CD58 | 965 | A_33_P3209096 | 0.8084 | 0.0986 | |
| SRP007169 | CD58 | 965 | RNAseq | 0.3281 | 0.4996 | |
| SRP008496 | CD58 | 965 | RNAseq | 0.2004 | 0.4559 | |
| SRP064894 | CD58 | 965 | RNAseq | 0.4813 | 0.0085 | |
| SRP133303 | CD58 | 965 | RNAseq | 0.5434 | 0.0094 | |
| SRP159526 | CD58 | 965 | RNAseq | -0.6361 | 0.0327 | |
| SRP193095 | CD58 | 965 | RNAseq | 0.0362 | 0.8033 | |
| SRP219564 | CD58 | 965 | RNAseq | 0.0903 | 0.8582 | |
| TCGA | CD58 | 965 | RNAseq | 0.2872 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CD58 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD58 | 965 | 0 | 9 | 21 | |
| GSE20123 | CD58 | 965 | 0 | 9 | 21 | |
| GSE43470 | CD58 | 965 | 0 | 5 | 38 | |
| GSE46452 | CD58 | 965 | 2 | 1 | 56 | |
| GSE47630 | CD58 | 965 | 9 | 5 | 26 | |
| GSE54993 | CD58 | 965 | 0 | 1 | 69 | |
| GSE54994 | CD58 | 965 | 10 | 2 | 41 | |
| GSE60625 | CD58 | 965 | 0 | 0 | 11 | |
| GSE74703 | CD58 | 965 | 0 | 4 | 32 | |
| GSE74704 | CD58 | 965 | 0 | 5 | 15 | |
| TCGA | CD58 | 965 | 14 | 28 | 54 |
Total number of gains: 35; Total number of losses: 69; Total Number of normals: 384.
Somatic mutations of CD58:
Generating mutation plots.
Highly correlated genes for CD58:
Showing top 20/102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD58 | RSL24D1 | 0.664504 | 4 | 0 | 4 |
| CD58 | COX6B2 | 0.66213 | 4 | 0 | 4 |
| CD58 | TOM1L1 | 0.640577 | 4 | 0 | 3 |
| CD58 | TMED4 | 0.615309 | 4 | 0 | 3 |
| CD58 | WNT5A | 0.609936 | 3 | 0 | 3 |
| CD58 | ADAM17 | 0.59727 | 3 | 0 | 3 |
| CD58 | RANBP1 | 0.592494 | 3 | 0 | 3 |
| CD58 | NDUFS4 | 0.592404 | 5 | 0 | 4 |
| CD58 | RBM18 | 0.59181 | 3 | 0 | 3 |
| CD58 | SLC7A5 | 0.584755 | 6 | 0 | 3 |
| CD58 | CLEC5A | 0.584266 | 3 | 0 | 3 |
| CD58 | PRC1 | 0.583623 | 3 | 0 | 3 |
| CD58 | ITGA6 | 0.579903 | 5 | 0 | 4 |
| CD58 | SLC25A46 | 0.571338 | 6 | 0 | 4 |
| CD58 | STAMBP | 0.569809 | 4 | 0 | 3 |
| CD58 | DUSP11 | 0.568712 | 8 | 0 | 5 |
| CD58 | MTHFD2 | 0.562435 | 3 | 0 | 3 |
| CD58 | ZWILCH | 0.561945 | 4 | 0 | 3 |
| CD58 | AK6 | 0.558227 | 5 | 0 | 3 |
| CD58 | NSMCE2 | 0.556736 | 4 | 0 | 3 |
For details and further investigation, click here
