CLEC5A

 

Full name: C-type lectin domain containing 5A Alias Symbol: MDL-1
Type: protein-coding gene Cytoband: 7q34
Entrez ID: 23601 HGNC ID: HGNC:2054 Ensembl Gene: ENSG00000258227 OMIM ID: 604987
Drug and gene relationship at DGIdb

 

Expression of CLEC5A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CLEC5A 23601 219890_at 0.8194 0.2034
GSE20347 CLEC5A 23601 219890_at 0.0737 0.6739
GSE23400 CLEC5A 23601 219890_at 0.0965 0.0871
GSE26886 CLEC5A 23601 219890_at -0.0756 0.8269
GSE29001 CLEC5A 23601 219890_at 0.0072 0.9841
GSE38129 CLEC5A 23601 219890_at 0.3865 0.0167
GSE45670 CLEC5A 23601 219890_at 0.2146 0.5093
GSE53622 CLEC5A 23601 121288 1.0505 0.0000
GSE53624 CLEC5A 23601 121288 0.9112 0.0000
GSE63941 CLEC5A 23601 219890_at 0.0165 0.8978
GSE77861 CLEC5A 23601 219890_at -0.0059 0.9599
SRP007169 CLEC5A 23601 RNAseq 1.4907 0.0552
SRP008496 CLEC5A 23601 RNAseq 0.9303 0.0552
SRP064894 CLEC5A 23601 RNAseq 1.2457 0.0003
SRP133303 CLEC5A 23601 RNAseq 1.8180 0.0000
SRP159526 CLEC5A 23601 RNAseq 0.0009 0.9990
SRP219564 CLEC5A 23601 RNAseq 0.4538 0.5525
TCGA CLEC5A 23601 RNAseq 1.9950 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by CLEC5A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CLEC5A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CLEC5A 23601 5 2 23
GSE20123 CLEC5A 23601 5 2 23
GSE43470 CLEC5A 23601 2 4 37
GSE46452 CLEC5A 23601 7 2 50
GSE47630 CLEC5A 23601 6 7 27
GSE54993 CLEC5A 23601 3 5 62
GSE54994 CLEC5A 23601 5 8 40
GSE60625 CLEC5A 23601 0 0 11
GSE74703 CLEC5A 23601 2 4 30
GSE74704 CLEC5A 23601 1 2 17
TCGA CLEC5A 23601 29 23 44

Total number of gains: 65; Total number of losses: 59; Total Number of normals: 364.  

 

Somatic mutations of CLEC5A:

 

Generating mutation plots.

 

Highly correlated genes for CLEC5A:

 

Showing top 20/110 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CLEC5AGPR840.684445403
CLEC5ACYP27B10.650004706
CLEC5ATLR20.644695404
CLEC5ATDO20.639932706
CLEC5ALRRC150.619847706
CLEC5AGLDC0.61859303
CLEC5AAQP90.616541807
CLEC5AFCGR1B0.613716403
CLEC5AUTP180.613598303
CLEC5AZNF4690.609277403
CLEC5AATP6V0D20.60866303
CLEC5ACEMIP0.607727404
CLEC5AANGPT20.605708404
CLEC5ARASGRP30.603418403
CLEC5APCYOX1L0.598058403
CLEC5AMMP120.595545604
CLEC5AMMP30.593776605
CLEC5AOLR10.586533906
CLEC5AIFNGR10.58471404
CLEC5ACD580.584266303

For details and further investigation, click here