| Full name: von Willebrand factor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 7450 | HGNC ID: HGNC:12726 | Ensembl Gene: ENSG00000110799 | OMIM ID: 613160 |
| Drug and gene relationship at DGIdb | |||
VWF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04610 | Complement and coagulation cascades | |
| hsa04611 | Platelet activation |
Expression of VWF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VWF | 7450 | 202112_at | -0.3606 | 0.6676 | |
| GSE20347 | VWF | 7450 | 202112_at | -0.7004 | 0.0000 | |
| GSE23400 | VWF | 7450 | 202112_at | -0.5164 | 0.0000 | |
| GSE26886 | VWF | 7450 | 202112_at | -1.3377 | 0.0000 | |
| GSE29001 | VWF | 7450 | 202112_at | -1.0414 | 0.0089 | |
| GSE38129 | VWF | 7450 | 202112_at | -0.9248 | 0.0016 | |
| GSE45670 | VWF | 7450 | 202112_at | -0.7003 | 0.0343 | |
| GSE53622 | VWF | 7450 | 12611 | -0.9252 | 0.0000 | |
| GSE53624 | VWF | 7450 | 12611 | -0.7979 | 0.0000 | |
| GSE63941 | VWF | 7450 | 202112_at | -0.0492 | 0.9353 | |
| GSE77861 | VWF | 7450 | 202112_at | -0.0684 | 0.8711 | |
| GSE97050 | VWF | A_21_P0012280 | 0.0838 | 0.7751 | ||
| SRP007169 | VWF | 7450 | RNAseq | 0.3188 | 0.4573 | |
| SRP008496 | VWF | 7450 | RNAseq | 0.0812 | 0.8363 | |
| SRP064894 | VWF | 7450 | RNAseq | 0.5841 | 0.0599 | |
| SRP133303 | VWF | 7450 | RNAseq | -1.0266 | 0.0001 | |
| SRP159526 | VWF | 7450 | RNAseq | -0.1435 | 0.8104 | |
| SRP193095 | VWF | 7450 | RNAseq | 0.5191 | 0.0033 | |
| SRP219564 | VWF | 7450 | RNAseq | -0.3701 | 0.5955 | |
| TCGA | VWF | 7450 | RNAseq | -0.3687 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by VWF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VWF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VWF | 7450 | 9 | 4 | 17 | |
| GSE20123 | VWF | 7450 | 9 | 4 | 17 | |
| GSE43470 | VWF | 7450 | 9 | 3 | 31 | |
| GSE46452 | VWF | 7450 | 10 | 1 | 48 | |
| GSE47630 | VWF | 7450 | 12 | 2 | 26 | |
| GSE54993 | VWF | 7450 | 1 | 10 | 59 | |
| GSE54994 | VWF | 7450 | 10 | 2 | 41 | |
| GSE60625 | VWF | 7450 | 0 | 1 | 10 | |
| GSE74703 | VWF | 7450 | 8 | 2 | 26 | |
| GSE74704 | VWF | 7450 | 5 | 2 | 13 | |
| TCGA | VWF | 7450 | 40 | 6 | 50 |
Total number of gains: 113; Total number of losses: 37; Total Number of normals: 338.
Somatic mutations of VWF:
Generating mutation plots.
Highly correlated genes for VWF:
Showing top 20/779 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VWF | ACKR1 | 0.732425 | 9 | 0 | 8 |
| VWF | CLEC14A | 0.729611 | 6 | 0 | 5 |
| VWF | ZNF423 | 0.728197 | 5 | 0 | 5 |
| VWF | PREX2 | 0.722616 | 3 | 0 | 3 |
| VWF | ECSCR | 0.705282 | 6 | 0 | 4 |
| VWF | COL14A1 | 0.699471 | 9 | 0 | 8 |
| VWF | TEK | 0.694526 | 8 | 0 | 7 |
| VWF | CLDN5 | 0.692097 | 9 | 0 | 7 |
| VWF | ST6GALNAC3 | 0.688746 | 4 | 0 | 4 |
| VWF | GIMAP1 | 0.68769 | 5 | 0 | 5 |
| VWF | PDE7B | 0.6863 | 4 | 0 | 4 |
| VWF | CNRIP1 | 0.686144 | 5 | 0 | 4 |
| VWF | CDH5 | 0.683107 | 11 | 0 | 10 |
| VWF | SMAP1 | 0.682983 | 3 | 0 | 3 |
| VWF | HSD11B1 | 0.68098 | 3 | 0 | 3 |
| VWF | BMX | 0.679664 | 6 | 0 | 5 |
| VWF | MMRN2 | 0.679381 | 6 | 0 | 6 |
| VWF | FHL5 | 0.677011 | 6 | 0 | 6 |
| VWF | MEOX2 | 0.676619 | 7 | 0 | 6 |
| VWF | BHLHE22 | 0.675306 | 4 | 0 | 4 |
For details and further investigation, click here
