LMNB2

 

Full name: lamin B2 Alias Symbol: 
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 84823 HGNC ID: HGNC:6638 Ensembl Gene: ENSG00000176619 OMIM ID: 150341
Drug and gene relationship at DGIdb

 

LMNB2 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of LMNB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LMNB2 84823 216952_s_at 1.4961 0.0174
GSE20347 LMNB2 84823 216952_s_at 0.8597 0.0002
GSE23400 LMNB2 84823 216952_s_at 0.9129 0.0000
GSE26886 LMNB2 84823 216952_s_at -0.2270 0.3277
GSE29001 LMNB2 84823 216952_s_at 1.0361 0.0054
GSE38129 LMNB2 84823 216952_s_at 1.3244 0.0000
GSE45670 LMNB2 84823 216952_s_at 1.1677 0.0000
GSE53622 LMNB2 84823 91808 0.6711 0.0000
GSE53624 LMNB2 84823 91808 0.5381 0.0000
GSE63941 LMNB2 84823 216952_s_at 0.9367 0.0039
GSE77861 LMNB2 84823 216952_s_at 1.1829 0.0011
GSE97050 LMNB2 84823 A_23_P67725 1.3319 0.0555
SRP007169 LMNB2 84823 RNAseq 2.9453 0.0000
SRP008496 LMNB2 84823 RNAseq 2.4524 0.0000
SRP064894 LMNB2 84823 RNAseq 1.0899 0.0000
SRP133303 LMNB2 84823 RNAseq 1.1977 0.0000
SRP159526 LMNB2 84823 RNAseq 1.1837 0.0000
SRP193095 LMNB2 84823 RNAseq 0.8988 0.0000
SRP219564 LMNB2 84823 RNAseq 1.0870 0.0197
TCGA LMNB2 84823 RNAseq 0.4943 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by LMNB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LMNB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LMNB2 84823 4 4 22
GSE20123 LMNB2 84823 4 4 22
GSE43470 LMNB2 84823 1 10 32
GSE46452 LMNB2 84823 47 1 11
GSE47630 LMNB2 84823 5 7 28
GSE54993 LMNB2 84823 16 3 51
GSE54994 LMNB2 84823 8 15 30
GSE60625 LMNB2 84823 9 0 2
GSE74703 LMNB2 84823 1 7 28
GSE74704 LMNB2 84823 2 3 15
TCGA LMNB2 84823 6 25 65

Total number of gains: 103; Total number of losses: 79; Total Number of normals: 306.  

 

Somatic mutations of LMNB2:

 

Generating mutation plots.

 

Highly correlated genes for LMNB2:

 

Showing top 20/1956 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LMNB2DDX39A0.795911011
LMNB2KHSRP0.788803707
LMNB2KPNA20.784949808
LMNB2LSM40.77826710010
LMNB2CDCA30.77748811010
LMNB2TTK0.77739410010
LMNB2CENPF0.77723112010
LMNB2MCM100.7763851009
LMNB2DNMT10.77276512011
LMNB2TMEM1380.772549505
LMNB2XPR10.771124606
LMNB2CEP550.76953513012
LMNB2RTKN0.769304707
LMNB2FZD60.769085808
LMNB2UBE2C0.76859613011
LMNB2PSME40.766961909
LMNB2KNSTRN0.766583606
LMNB2PLXNA10.7638510010
LMNB2NUF20.7616807
LMNB2SIX40.760346606

For details and further investigation, click here