| Full name: claudin 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 9073 | HGNC ID: HGNC:2050 | Ensembl Gene: ENSG00000156284 | OMIM ID: 611231 |
| Drug and gene relationship at DGIdb | |||
CLDN8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN8 | 9073 | 214598_at | -1.2569 | 0.5258 | |
| GSE20347 | CLDN8 | 9073 | 214598_at | -0.7119 | 0.1763 | |
| GSE23400 | CLDN8 | 9073 | 214598_at | -0.0754 | 0.6136 | |
| GSE26886 | CLDN8 | 9073 | 214598_at | -1.1412 | 0.0322 | |
| GSE29001 | CLDN8 | 9073 | 214598_at | -1.7839 | 0.0002 | |
| GSE38129 | CLDN8 | 9073 | 214598_at | -0.2065 | 0.6955 | |
| GSE45670 | CLDN8 | 9073 | 214598_at | -0.8465 | 0.2131 | |
| GSE53622 | CLDN8 | 9073 | 8989 | -1.2112 | 0.0008 | |
| GSE53624 | CLDN8 | 9073 | 8989 | -2.5036 | 0.0000 | |
| GSE63941 | CLDN8 | 9073 | 214598_at | 1.1273 | 0.2581 | |
| GSE77861 | CLDN8 | 9073 | 214598_at | -0.2442 | 0.7766 | |
| SRP007169 | CLDN8 | 9073 | RNAseq | -0.3874 | 0.7083 | |
| SRP064894 | CLDN8 | 9073 | RNAseq | -1.3973 | 0.1140 | |
| SRP133303 | CLDN8 | 9073 | RNAseq | 0.8992 | 0.3839 | |
| SRP159526 | CLDN8 | 9073 | RNAseq | 1.8513 | 0.2278 | |
| TCGA | CLDN8 | 9073 | RNAseq | 1.3138 | 0.0355 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by CLDN8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN8 | 9073 | 2 | 9 | 19 | |
| GSE20123 | CLDN8 | 9073 | 2 | 9 | 19 | |
| GSE43470 | CLDN8 | 9073 | 2 | 9 | 32 | |
| GSE46452 | CLDN8 | 9073 | 1 | 21 | 37 | |
| GSE47630 | CLDN8 | 9073 | 6 | 17 | 17 | |
| GSE54993 | CLDN8 | 9073 | 9 | 1 | 60 | |
| GSE54994 | CLDN8 | 9073 | 1 | 9 | 43 | |
| GSE60625 | CLDN8 | 9073 | 0 | 0 | 11 | |
| GSE74703 | CLDN8 | 9073 | 2 | 6 | 28 | |
| GSE74704 | CLDN8 | 9073 | 2 | 6 | 12 | |
| TCGA | CLDN8 | 9073 | 8 | 38 | 50 |
Total number of gains: 35; Total number of losses: 125; Total Number of normals: 328.
Somatic mutations of CLDN8:
Generating mutation plots.
Highly correlated genes for CLDN8:
Showing top 20/234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN8 | MBNL3 | 0.660404 | 4 | 0 | 3 |
| CLDN8 | TNNT3 | 0.656985 | 3 | 0 | 3 |
| CLDN8 | IFNAR1 | 0.651182 | 3 | 0 | 3 |
| CLDN8 | ZNF85 | 0.634849 | 4 | 0 | 3 |
| CLDN8 | HYKK | 0.633833 | 3 | 0 | 3 |
| CLDN8 | REPS1 | 0.633414 | 4 | 0 | 3 |
| CLDN8 | TCEA3 | 0.632514 | 4 | 0 | 3 |
| CLDN8 | RIPK4 | 0.618799 | 7 | 0 | 6 |
| CLDN8 | EFHC2 | 0.617258 | 3 | 0 | 3 |
| CLDN8 | ALKBH7 | 0.612363 | 4 | 0 | 3 |
| CLDN8 | ST6GALNAC1 | 0.612295 | 6 | 0 | 5 |
| CLDN8 | SNX31 | 0.610539 | 5 | 0 | 4 |
| CLDN8 | CYP4F3 | 0.59952 | 11 | 0 | 9 |
| CLDN8 | CTDSP1 | 0.598737 | 4 | 0 | 3 |
| CLDN8 | PAIP2B | 0.598539 | 5 | 0 | 4 |
| CLDN8 | FAM3B | 0.595866 | 5 | 0 | 4 |
| CLDN8 | KRT15 | 0.59401 | 9 | 0 | 8 |
| CLDN8 | CACNB4 | 0.591024 | 3 | 0 | 3 |
| CLDN8 | ZNF518A | 0.589674 | 4 | 0 | 4 |
| CLDN8 | SAMD13 | 0.589313 | 4 | 0 | 3 |
For details and further investigation, click here
