| Full name: oxidized low density lipoprotein receptor 1 | Alias Symbol: LOX-1|SCARE1|CLEC8A | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 4973 | HGNC ID: HGNC:8133 | Ensembl Gene: ENSG00000173391 | OMIM ID: 602601 |
| Drug and gene relationship at DGIdb | |||
OLR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of OLR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OLR1 | 4973 | 210004_at | 0.4554 | 0.3351 | |
| GSE20347 | OLR1 | 4973 | 210004_at | 0.1450 | 0.0703 | |
| GSE23400 | OLR1 | 4973 | 210004_at | 0.3007 | 0.0026 | |
| GSE26886 | OLR1 | 4973 | 210004_at | 0.3479 | 0.0124 | |
| GSE29001 | OLR1 | 4973 | 210004_at | 0.3652 | 0.1182 | |
| GSE38129 | OLR1 | 4973 | 210004_at | 0.5418 | 0.0049 | |
| GSE45670 | OLR1 | 4973 | 210004_at | 0.2509 | 0.2278 | |
| GSE53622 | OLR1 | 4973 | 30086 | 2.7700 | 0.0000 | |
| GSE53624 | OLR1 | 4973 | 30086 | 2.3579 | 0.0000 | |
| GSE63941 | OLR1 | 4973 | 210004_at | -2.2082 | 0.4064 | |
| GSE77861 | OLR1 | 4973 | 210004_at | -0.0610 | 0.5088 | |
| GSE97050 | OLR1 | 4973 | A_24_P124624 | 0.7941 | 0.1581 | |
| SRP007169 | OLR1 | 4973 | RNAseq | 4.5791 | 0.0000 | |
| SRP008496 | OLR1 | 4973 | RNAseq | 7.1760 | 0.0000 | |
| SRP064894 | OLR1 | 4973 | RNAseq | 3.5623 | 0.0000 | |
| SRP133303 | OLR1 | 4973 | RNAseq | 1.9326 | 0.0000 | |
| SRP159526 | OLR1 | 4973 | RNAseq | 1.1103 | 0.1947 | |
| SRP193095 | OLR1 | 4973 | RNAseq | 1.4269 | 0.0000 | |
| SRP219564 | OLR1 | 4973 | RNAseq | 4.7380 | 0.0000 | |
| TCGA | OLR1 | 4973 | RNAseq | 2.2126 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by OLR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OLR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OLR1 | 4973 | 6 | 2 | 22 | |
| GSE20123 | OLR1 | 4973 | 6 | 2 | 22 | |
| GSE43470 | OLR1 | 4973 | 8 | 3 | 32 | |
| GSE46452 | OLR1 | 4973 | 10 | 1 | 48 | |
| GSE47630 | OLR1 | 4973 | 14 | 2 | 24 | |
| GSE54993 | OLR1 | 4973 | 1 | 10 | 59 | |
| GSE54994 | OLR1 | 4973 | 9 | 2 | 42 | |
| GSE60625 | OLR1 | 4973 | 0 | 1 | 10 | |
| GSE74703 | OLR1 | 4973 | 8 | 2 | 26 | |
| GSE74704 | OLR1 | 4973 | 4 | 1 | 15 | |
| TCGA | OLR1 | 4973 | 39 | 6 | 51 |
Total number of gains: 105; Total number of losses: 32; Total Number of normals: 351.
Somatic mutations of OLR1:
Generating mutation plots.
Highly correlated genes for OLR1:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OLR1 | TMEM200A | 0.76206 | 4 | 0 | 4 |
| OLR1 | ATP6V0D2 | 0.758251 | 3 | 0 | 3 |
| OLR1 | FCGR3A | 0.756649 | 3 | 0 | 3 |
| OLR1 | LRRC8C | 0.731161 | 3 | 0 | 3 |
| OLR1 | GPR84 | 0.689173 | 4 | 0 | 3 |
| OLR1 | ANGPT2 | 0.68613 | 4 | 0 | 4 |
| OLR1 | PARP14 | 0.683881 | 4 | 0 | 4 |
| OLR1 | GUCY1A2 | 0.683265 | 3 | 0 | 3 |
| OLR1 | LY75 | 0.682934 | 3 | 0 | 3 |
| OLR1 | ESM1 | 0.68285 | 5 | 0 | 5 |
| OLR1 | DCAF13 | 0.682423 | 5 | 0 | 5 |
| OLR1 | PDIA5 | 0.681315 | 3 | 0 | 3 |
| OLR1 | RBM12B | 0.67281 | 3 | 0 | 3 |
| OLR1 | CDH11 | 0.671592 | 5 | 0 | 4 |
| OLR1 | PPP6R1 | 0.670312 | 3 | 0 | 3 |
| OLR1 | COL22A1 | 0.669168 | 3 | 0 | 3 |
| OLR1 | IKBIP | 0.668543 | 5 | 0 | 4 |
| OLR1 | SPON2 | 0.667994 | 3 | 0 | 3 |
| OLR1 | PYCR2 | 0.664876 | 3 | 0 | 3 |
| OLR1 | SAAL1 | 0.664858 | 3 | 0 | 3 |
For details and further investigation, click here
