| Full name: ciliary rootlet coiled-coil, rootletin | Alias Symbol: rootletin|ROLT | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 9696 | HGNC ID: HGNC:21299 | Ensembl Gene: ENSG00000058453 | OMIM ID: 615776 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CROCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CROCC | 9696 | 206274_s_at | 0.4939 | 0.4105 | |
| GSE20347 | CROCC | 9696 | 206274_s_at | 0.3793 | 0.0252 | |
| GSE23400 | CROCC | 9696 | 216419_at | -0.0207 | 0.6722 | |
| GSE26886 | CROCC | 9696 | 216419_at | 0.2983 | 0.0339 | |
| GSE29001 | CROCC | 9696 | 206274_s_at | 0.1759 | 0.4123 | |
| GSE38129 | CROCC | 9696 | 206274_s_at | 0.3267 | 0.0419 | |
| GSE45670 | CROCC | 9696 | 206274_s_at | 0.2219 | 0.1694 | |
| GSE53622 | CROCC | 9696 | 29272 | 0.3779 | 0.0002 | |
| GSE53624 | CROCC | 9696 | 29272 | 0.5191 | 0.0000 | |
| GSE63941 | CROCC | 9696 | 206274_s_at | -0.1879 | 0.6126 | |
| GSE77861 | CROCC | 9696 | 216419_at | 0.0873 | 0.6264 | |
| GSE97050 | CROCC | A_21_P0010601 | -0.0465 | 0.8573 | ||
| SRP007169 | CROCC | 9696 | RNAseq | 1.7203 | 0.0319 | |
| SRP064894 | CROCC | 9696 | RNAseq | 0.5581 | 0.0178 | |
| SRP133303 | CROCC | 9696 | RNAseq | -0.0127 | 0.9545 | |
| SRP159526 | CROCC | 9696 | RNAseq | 0.7813 | 0.0576 | |
| SRP193095 | CROCC | 9696 | RNAseq | 0.9586 | 0.0000 | |
| SRP219564 | CROCC | 9696 | RNAseq | 0.2155 | 0.5733 | |
| TCGA | CROCC | 9696 | RNAseq | 0.0790 | 0.3585 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CROCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CROCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CROCC | 9696 | 0 | 5 | 25 | |
| GSE20123 | CROCC | 9696 | 0 | 4 | 26 | |
| GSE43470 | CROCC | 9696 | 2 | 8 | 33 | |
| GSE46452 | CROCC | 9696 | 5 | 1 | 53 | |
| GSE47630 | CROCC | 9696 | 8 | 3 | 29 | |
| GSE54993 | CROCC | 9696 | 3 | 1 | 66 | |
| GSE54994 | CROCC | 9696 | 10 | 4 | 39 | |
| GSE60625 | CROCC | 9696 | 0 | 0 | 11 | |
| GSE74703 | CROCC | 9696 | 2 | 5 | 29 | |
| GSE74704 | CROCC | 9696 | 0 | 0 | 20 | |
| TCGA | CROCC | 9696 | 9 | 23 | 64 |
Total number of gains: 39; Total number of losses: 54; Total Number of normals: 395.
Somatic mutations of CROCC:
Generating mutation plots.
Highly correlated genes for CROCC:
Showing top 20/145 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CROCC | ZNF385A | 0.669157 | 3 | 0 | 3 |
| CROCC | SLC12A5 | 0.662304 | 3 | 0 | 3 |
| CROCC | UBALD1 | 0.644056 | 4 | 0 | 3 |
| CROCC | OTX1 | 0.629234 | 4 | 0 | 4 |
| CROCC | WDR24 | 0.627899 | 3 | 0 | 3 |
| CROCC | SF3B4 | 0.626624 | 3 | 0 | 3 |
| CROCC | C19orf53 | 0.626462 | 3 | 0 | 3 |
| CROCC | PYY | 0.626285 | 4 | 0 | 4 |
| CROCC | FBXO44 | 0.621386 | 3 | 0 | 3 |
| CROCC | HIP1R | 0.61729 | 4 | 0 | 3 |
| CROCC | ZNF746 | 0.61214 | 3 | 0 | 3 |
| CROCC | METTL1 | 0.608252 | 5 | 0 | 4 |
| CROCC | ANAPC2 | 0.606972 | 6 | 0 | 5 |
| CROCC | TET1 | 0.605491 | 3 | 0 | 3 |
| CROCC | PAGR1 | 0.602505 | 4 | 0 | 3 |
| CROCC | RBM42 | 0.602122 | 5 | 0 | 3 |
| CROCC | ANKRD54 | 0.601136 | 3 | 0 | 3 |
| CROCC | TBC1D10B | 0.600413 | 5 | 0 | 4 |
| CROCC | ARFIP2 | 0.598833 | 3 | 0 | 3 |
| CROCC | HIF1AN | 0.596231 | 3 | 0 | 3 |
For details and further investigation, click here
