Full name: negative elongation factor complex member C/D	Alias Symbol: HSPC130|TH1|NELF-C|NELF-D
Type: protein-coding gene	Cytoband: 20q13.32
Entrez ID: 51497	HGNC ID: HGNC:15934	Ensembl Gene: ENSG00000101158	OMIM ID: 605297
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 185/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of NELFCD:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	NELFCD	51497	220607_x_at	0.8303	0.0553	Show
GSE20347	NELFCD	51497	220607_x_at	0.6293	0.0004	Show
GSE23400	NELFCD	51497	220607_x_at	0.7422	0.0000	Show
GSE26886	NELFCD	51497	225006_x_at	0.2327	0.2188	Show
GSE29001	NELFCD	51497	220607_x_at	0.7433	0.0657	Show
GSE38129	NELFCD	51497	220607_x_at	0.7743	0.0000	Show
GSE45670	NELFCD	51497	225006_x_at	0.5328	0.0093	Show
GSE53622	NELFCD	51497	62661	0.3724	0.0000	Show
GSE53624	NELFCD	51497	62661	0.6762	0.0000	Show
GSE63941	NELFCD	51497	220607_x_at	1.6002	0.0007	Show
GSE77861	NELFCD	51497	220607_x_at	0.4514	0.0564	Show
SRP007169	NELFCD	51497	RNAseq	0.1561	0.6215	Show
SRP008496	NELFCD	51497	RNAseq	0.2994	0.0982	Show
SRP064894	NELFCD	51497	RNAseq	0.5477	0.0056	Show
SRP133303	NELFCD	51497	RNAseq	0.4855	0.0029	Show
SRP159526	NELFCD	51497	RNAseq	0.7491	0.0427	Show
SRP193095	NELFCD	51497	RNAseq	0.2859	0.0009	Show
SRP219564	NELFCD	51497	RNAseq	0.6984	0.0369	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

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Survival by NELFCD expression:

 

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Copy number change of NELFCD:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	NELFCD	51497	14	2	14	Show
GSE20123	NELFCD	51497	14	2	14	Show
GSE43470	NELFCD	51497	13	0	30	Show
GSE46452	NELFCD	51497	29	0	30	Show
GSE47630	NELFCD	51497	24	1	15	Show
GSE54993	NELFCD	51497	0	17	53	Show
GSE54994	NELFCD	51497	29	0	24	Show
GSE60625	NELFCD	51497	0	0	11	Show
GSE74703	NELFCD	51497	11	0	25	Show
GSE74704	NELFCD	51497	11	0	9	Show
TCGA	NELFCD	51497	43	4	49	Show

Total number of gains: 188; Total number of losses: 26; Total Number of normals: 274.  Download Data

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Somatic mutations of NELFCD:

 

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Highly correlated genes for NELFCD:

 

Showing top 20/1211 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
NELFCD	CSE1L	0.802368	10	0	10
NELFCD	CSTF1	0.764468	11	0	11
NELFCD	TPX2	0.753816	10	0	10
NELFCD	UBE2C	0.737835	10	0	10
NELFCD	PSMA7	0.732091	10	0	9
NELFCD	AURKA	0.711636	9	0	9
NELFCD	CENPN	0.709149	10	0	10
NELFCD	SNRPB	0.707374	10	0	10
NELFCD	MCM2	0.702871	10	0	10
NELFCD	GINS1	0.70248	11	0	9
NELFCD	RUVBL1	0.697607	11	0	11
NELFCD	PCNA	0.696736	11	0	10
NELFCD	CDCA5	0.696432	6	0	6
NELFCD	ILF2	0.693649	10	0	9
NELFCD	MYBL2	0.689716	10	0	10
NELFCD	DSN1	0.688214	10	0	9
NELFCD	CCT2	0.687268	10	0	10
NELFCD	RAE1	0.68708	11	0	9
NELFCD	PBK	0.683873	10	0	10
NELFCD	CENPM	0.683752	9	0	9

For details and further investigation, click here