| Full name: C-X-C motif chemokine ligand 6 | Alias Symbol: GCP-2|CKA-3 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 6372 | HGNC ID: HGNC:10643 | Ensembl Gene: ENSG00000124875 | OMIM ID: 138965 |
| Drug and gene relationship at DGIdb | |||
CXCL6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CXCL6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCL6 | 6372 | 206336_at | 2.5933 | 0.2643 | |
| GSE20347 | CXCL6 | 6372 | 206336_at | 0.9701 | 0.0149 | |
| GSE23400 | CXCL6 | 6372 | 206336_at | 0.3856 | 0.0006 | |
| GSE26886 | CXCL6 | 6372 | 206336_at | 1.0817 | 0.2500 | |
| GSE29001 | CXCL6 | 6372 | 206336_at | 1.0185 | 0.0041 | |
| GSE38129 | CXCL6 | 6372 | 206336_at | 1.5310 | 0.0000 | |
| GSE45670 | CXCL6 | 6372 | 206336_at | 4.3755 | 0.0000 | |
| GSE53622 | CXCL6 | 6372 | 38787 | 3.0879 | 0.0000 | |
| GSE53624 | CXCL6 | 6372 | 38787 | 2.4619 | 0.0000 | |
| GSE63941 | CXCL6 | 6372 | 206336_at | -5.9876 | 0.0039 | |
| GSE77861 | CXCL6 | 6372 | 206336_at | 1.4816 | 0.0472 | |
| SRP007169 | CXCL6 | 6372 | RNAseq | 4.1594 | 0.0021 | |
| SRP133303 | CXCL6 | 6372 | RNAseq | 3.0374 | 0.0000 | |
| SRP159526 | CXCL6 | 6372 | RNAseq | 5.0957 | 0.0000 | |
| SRP219564 | CXCL6 | 6372 | RNAseq | 2.4938 | 0.0108 | |
| TCGA | CXCL6 | 6372 | RNAseq | 1.7036 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 1.
Survival by CXCL6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXCL6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCL6 | 6372 | 2 | 9 | 19 | |
| GSE20123 | CXCL6 | 6372 | 2 | 9 | 19 | |
| GSE43470 | CXCL6 | 6372 | 0 | 13 | 30 | |
| GSE46452 | CXCL6 | 6372 | 3 | 34 | 22 | |
| GSE47630 | CXCL6 | 6372 | 1 | 19 | 20 | |
| GSE54993 | CXCL6 | 6372 | 7 | 0 | 63 | |
| GSE54994 | CXCL6 | 6372 | 1 | 9 | 43 | |
| GSE60625 | CXCL6 | 6372 | 0 | 0 | 11 | |
| GSE74703 | CXCL6 | 6372 | 0 | 11 | 25 | |
| GSE74704 | CXCL6 | 6372 | 2 | 5 | 13 | |
| TCGA | CXCL6 | 6372 | 19 | 27 | 50 |
Total number of gains: 37; Total number of losses: 136; Total Number of normals: 315.
Somatic mutations of CXCL6:
Generating mutation plots.
Highly correlated genes for CXCL6:
Showing top 20/485 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCL6 | CXCL1 | 0.817794 | 12 | 0 | 12 |
| CXCL6 | TNFSF13B | 0.681671 | 3 | 0 | 3 |
| CXCL6 | CXCL8 | 0.677797 | 11 | 0 | 9 |
| CXCL6 | BPGM | 0.661385 | 3 | 0 | 3 |
| CXCL6 | POC1A | 0.65097 | 5 | 0 | 5 |
| CXCL6 | C2CD4A | 0.650547 | 5 | 0 | 5 |
| CXCL6 | ANGPT2 | 0.637735 | 7 | 0 | 6 |
| CXCL6 | CPSF3 | 0.636808 | 4 | 0 | 3 |
| CXCL6 | STRIP2 | 0.636548 | 6 | 0 | 6 |
| CXCL6 | SHCBP1 | 0.634544 | 9 | 0 | 8 |
| CXCL6 | STEAP1B | 0.6307 | 5 | 0 | 4 |
| CXCL6 | PF4V1 | 0.629652 | 8 | 0 | 7 |
| CXCL6 | C12orf75 | 0.628788 | 5 | 0 | 4 |
| CXCL6 | ABCA13 | 0.624677 | 4 | 0 | 3 |
| CXCL6 | BCL2A1 | 0.624292 | 10 | 0 | 8 |
| CXCL6 | S100A7A | 0.621545 | 4 | 0 | 4 |
| CXCL6 | PLAT | 0.620833 | 9 | 0 | 6 |
| CXCL6 | CLSPN | 0.620413 | 6 | 0 | 5 |
| CXCL6 | UHRF1 | 0.619545 | 6 | 0 | 5 |
| CXCL6 | TMEM138 | 0.618777 | 5 | 0 | 5 |
For details and further investigation, click here
