| Full name: C2 calcium dependent domain containing 4A | Alias Symbol: NLF1 | ||
| Type: protein-coding gene | Cytoband: 15q22.2 | ||
| Entrez ID: 145741 | HGNC ID: HGNC:33627 | Ensembl Gene: ENSG00000198535 | OMIM ID: 610343 |
| Drug and gene relationship at DGIdb | |||
Expression of C2CD4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C2CD4A | 145741 | 241031_at | 0.3438 | 0.1557 | |
| GSE26886 | C2CD4A | 145741 | 241031_at | 0.4046 | 0.0369 | |
| GSE45670 | C2CD4A | 145741 | 241031_at | 0.8010 | 0.0120 | |
| GSE53622 | C2CD4A | 145741 | 20136 | 1.2560 | 0.0000 | |
| GSE53624 | C2CD4A | 145741 | 20136 | 1.6080 | 0.0000 | |
| GSE63941 | C2CD4A | 145741 | 241031_at | 0.2771 | 0.7855 | |
| GSE77861 | C2CD4A | 145741 | 241031_at | 0.0587 | 0.7158 | |
| SRP133303 | C2CD4A | 145741 | RNAseq | 0.6341 | 0.0376 | |
| SRP193095 | C2CD4A | 145741 | RNAseq | 0.5954 | 0.0020 | |
| SRP219564 | C2CD4A | 145741 | RNAseq | 2.4677 | 0.0000 | |
| TCGA | C2CD4A | 145741 | RNAseq | 0.0435 | 0.8984 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by C2CD4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C2CD4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C2CD4A | 145741 | 7 | 3 | 20 | |
| GSE20123 | C2CD4A | 145741 | 7 | 2 | 21 | |
| GSE43470 | C2CD4A | 145741 | 4 | 6 | 33 | |
| GSE46452 | C2CD4A | 145741 | 3 | 7 | 49 | |
| GSE47630 | C2CD4A | 145741 | 8 | 10 | 22 | |
| GSE54993 | C2CD4A | 145741 | 5 | 6 | 59 | |
| GSE54994 | C2CD4A | 145741 | 6 | 8 | 39 | |
| GSE60625 | C2CD4A | 145741 | 4 | 0 | 7 | |
| GSE74703 | C2CD4A | 145741 | 4 | 3 | 29 | |
| GSE74704 | C2CD4A | 145741 | 3 | 3 | 14 | |
| TCGA | C2CD4A | 145741 | 10 | 17 | 69 |
Total number of gains: 61; Total number of losses: 65; Total Number of normals: 362.
Somatic mutations of C2CD4A:
Generating mutation plots.
Highly correlated genes for C2CD4A:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C2CD4A | LINC00460 | 0.750866 | 3 | 0 | 3 |
| C2CD4A | CDH3 | 0.714944 | 3 | 0 | 3 |
| C2CD4A | CERCAM | 0.677807 | 3 | 0 | 3 |
| C2CD4A | RUNX1-IT1 | 0.673255 | 3 | 0 | 3 |
| C2CD4A | CXCL1 | 0.67323 | 5 | 0 | 5 |
| C2CD4A | CXCL6 | 0.650547 | 5 | 0 | 5 |
| C2CD4A | CDC6 | 0.650047 | 3 | 0 | 3 |
| C2CD4A | CXCL8 | 0.646663 | 5 | 0 | 5 |
| C2CD4A | CYP27C1 | 0.645077 | 4 | 0 | 3 |
| C2CD4A | FEN1 | 0.642474 | 3 | 0 | 3 |
| C2CD4A | ORC6 | 0.627472 | 4 | 0 | 3 |
| C2CD4A | ABCA12 | 0.621668 | 4 | 0 | 3 |
| C2CD4A | MYO1B | 0.61539 | 4 | 0 | 3 |
| C2CD4A | MTHFD2 | 0.61023 | 5 | 0 | 3 |
| C2CD4A | LIPG | 0.604882 | 6 | 0 | 4 |
| C2CD4A | ADAM8 | 0.600271 | 4 | 0 | 3 |
| C2CD4A | ZNF114 | 0.598961 | 4 | 0 | 3 |
| C2CD4A | TREM1 | 0.588127 | 6 | 0 | 3 |
| C2CD4A | MMP3 | 0.581503 | 5 | 0 | 4 |
| C2CD4A | MED27 | 0.579992 | 4 | 0 | 3 |
For details and further investigation, click here
