| Full name: kallikrein related peptidase 8 | Alias Symbol: HNP|TADG14|neuropsin|ovasin | ||
| Type: protein-coding gene | Cytoband: 19q13 | ||
| Entrez ID: 11202 | HGNC ID: HGNC:6369 | Ensembl Gene: ENSG00000129455 | OMIM ID: 605644 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK8 | 11202 | 206125_s_at | -1.4914 | 0.4003 | |
| GSE20347 | KLK8 | 11202 | 206125_s_at | -1.7591 | 0.0001 | |
| GSE23400 | KLK8 | 11202 | 206125_s_at | -1.2326 | 0.0000 | |
| GSE26886 | KLK8 | 11202 | 206125_s_at | -1.4494 | 0.0004 | |
| GSE29001 | KLK8 | 11202 | 206125_s_at | -1.8854 | 0.0005 | |
| GSE38129 | KLK8 | 11202 | 206125_s_at | -0.8508 | 0.1190 | |
| GSE45670 | KLK8 | 11202 | 206125_s_at | 0.5160 | 0.2106 | |
| GSE53622 | KLK8 | 11202 | 139384 | -0.7746 | 0.0609 | |
| GSE53624 | KLK8 | 11202 | 139384 | -1.1952 | 0.0000 | |
| GSE63941 | KLK8 | 11202 | 206125_s_at | 2.8993 | 0.0605 | |
| GSE77861 | KLK8 | 11202 | 206125_s_at | -0.2871 | 0.6241 | |
| GSE97050 | KLK8 | 11202 | A_23_P369343 | 0.7558 | 0.0826 | |
| SRP007169 | KLK8 | 11202 | RNAseq | -2.5421 | 0.1370 | |
| SRP008496 | KLK8 | 11202 | RNAseq | -3.1567 | 0.0004 | |
| SRP064894 | KLK8 | 11202 | RNAseq | -0.8292 | 0.1654 | |
| SRP133303 | KLK8 | 11202 | RNAseq | -0.3312 | 0.4100 | |
| SRP159526 | KLK8 | 11202 | RNAseq | -1.5202 | 0.0544 | |
| SRP219564 | KLK8 | 11202 | RNAseq | -2.5943 | 0.0331 | |
| TCGA | KLK8 | 11202 | RNAseq | 1.4409 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 7.
Survival by KLK8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK8 | 11202 | 3 | 4 | 23 | |
| GSE20123 | KLK8 | 11202 | 3 | 3 | 24 | |
| GSE43470 | KLK8 | 11202 | 4 | 11 | 28 | |
| GSE46452 | KLK8 | 11202 | 45 | 1 | 13 | |
| GSE47630 | KLK8 | 11202 | 9 | 6 | 25 | |
| GSE54993 | KLK8 | 11202 | 17 | 4 | 49 | |
| GSE54994 | KLK8 | 11202 | 4 | 14 | 35 | |
| GSE60625 | KLK8 | 11202 | 9 | 0 | 2 | |
| GSE74703 | KLK8 | 11202 | 4 | 7 | 25 | |
| GSE74704 | KLK8 | 11202 | 3 | 1 | 16 | |
| TCGA | KLK8 | 11202 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK8:
Generating mutation plots.
Highly correlated genes for KLK8:
Showing top 20/758 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK8 | KLK10 | 0.805028 | 9 | 0 | 9 |
| KLK8 | KLK7 | 0.783345 | 12 | 0 | 12 |
| KLK8 | SBSN | 0.775634 | 7 | 0 | 7 |
| KLK8 | SULT2B1 | 0.764395 | 9 | 0 | 9 |
| KLK8 | KRT6C | 0.756794 | 4 | 0 | 4 |
| KLK8 | SPRR2D | 0.754576 | 4 | 0 | 4 |
| KLK8 | TMPRSS11D | 0.751643 | 11 | 0 | 11 |
| KLK8 | KLK11 | 0.748944 | 12 | 0 | 11 |
| KLK8 | SPRR2A | 0.743801 | 4 | 0 | 4 |
| KLK8 | SPRR2E | 0.741358 | 4 | 0 | 4 |
| KLK8 | SPRR1B | 0.740305 | 11 | 0 | 11 |
| KLK8 | FUT2 | 0.732257 | 10 | 0 | 10 |
| KLK8 | TGM1 | 0.730525 | 12 | 0 | 11 |
| KLK8 | DMKN | 0.726675 | 8 | 0 | 7 |
| KLK8 | SERPINB4 | 0.726478 | 11 | 0 | 11 |
| KLK8 | SERPINB3 | 0.725014 | 10 | 0 | 10 |
| KLK8 | SPRR2F | 0.721629 | 4 | 0 | 4 |
| KLK8 | PGLYRP3 | 0.720159 | 4 | 0 | 3 |
| KLK8 | KLK13 | 0.712085 | 12 | 0 | 11 |
| KLK8 | C10orf99 | 0.708328 | 8 | 0 | 7 |
For details and further investigation, click here
