| Full name: solute carrier family 11 member 2 | Alias Symbol: DCT1|DMT1 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 4891 | HGNC ID: HGNC:10908 | Ensembl Gene: ENSG00000110911 | OMIM ID: 600523 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC11A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC11A2 | 4891 | 203124_s_at | -0.5754 | 0.5189 | |
| GSE20347 | SLC11A2 | 4891 | 203124_s_at | -0.7552 | 0.0001 | |
| GSE23400 | SLC11A2 | 4891 | 203123_s_at | -0.6282 | 0.0000 | |
| GSE26886 | SLC11A2 | 4891 | 203124_s_at | -1.3394 | 0.0000 | |
| GSE29001 | SLC11A2 | 4891 | 203124_s_at | -0.8115 | 0.0028 | |
| GSE38129 | SLC11A2 | 4891 | 203124_s_at | -0.3328 | 0.1930 | |
| GSE45670 | SLC11A2 | 4891 | 203124_s_at | -0.1129 | 0.6767 | |
| GSE53622 | SLC11A2 | 4891 | 33446 | -0.4655 | 0.0000 | |
| GSE53624 | SLC11A2 | 4891 | 33446 | -0.6409 | 0.0000 | |
| GSE63941 | SLC11A2 | 4891 | 203124_s_at | 0.0531 | 0.9506 | |
| GSE77861 | SLC11A2 | 4891 | 203124_s_at | -0.8088 | 0.0130 | |
| GSE97050 | SLC11A2 | 4891 | A_23_P139820 | 0.0931 | 0.7578 | |
| SRP007169 | SLC11A2 | 4891 | RNAseq | -1.1285 | 0.0022 | |
| SRP008496 | SLC11A2 | 4891 | RNAseq | -1.0818 | 0.0000 | |
| SRP064894 | SLC11A2 | 4891 | RNAseq | -0.6937 | 0.0017 | |
| SRP133303 | SLC11A2 | 4891 | RNAseq | -0.2034 | 0.1821 | |
| SRP159526 | SLC11A2 | 4891 | RNAseq | -0.5483 | 0.0960 | |
| SRP193095 | SLC11A2 | 4891 | RNAseq | -0.4401 | 0.0042 | |
| SRP219564 | SLC11A2 | 4891 | RNAseq | -0.4014 | 0.2622 | |
| TCGA | SLC11A2 | 4891 | RNAseq | -0.0480 | 0.3712 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SLC11A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC11A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC11A2 | 4891 | 8 | 1 | 21 | |
| GSE20123 | SLC11A2 | 4891 | 8 | 1 | 21 | |
| GSE43470 | SLC11A2 | 4891 | 3 | 0 | 40 | |
| GSE46452 | SLC11A2 | 4891 | 8 | 1 | 50 | |
| GSE47630 | SLC11A2 | 4891 | 11 | 2 | 27 | |
| GSE54993 | SLC11A2 | 4891 | 0 | 5 | 65 | |
| GSE54994 | SLC11A2 | 4891 | 3 | 2 | 48 | |
| GSE60625 | SLC11A2 | 4891 | 0 | 0 | 11 | |
| GSE74703 | SLC11A2 | 4891 | 3 | 0 | 33 | |
| GSE74704 | SLC11A2 | 4891 | 5 | 1 | 14 | |
| TCGA | SLC11A2 | 4891 | 14 | 11 | 71 |
Total number of gains: 63; Total number of losses: 24; Total Number of normals: 401.
Somatic mutations of SLC11A2:
Generating mutation plots.
Highly correlated genes for SLC11A2:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC11A2 | EPS15 | 0.765193 | 3 | 0 | 3 |
| SLC11A2 | ACTR2 | 0.762257 | 3 | 0 | 3 |
| SLC11A2 | USP6NL | 0.759743 | 10 | 0 | 10 |
| SLC11A2 | SMAGP | 0.745599 | 11 | 0 | 11 |
| SLC11A2 | ZDHHC13 | 0.742552 | 11 | 0 | 11 |
| SLC11A2 | FUT3 | 0.741125 | 12 | 0 | 12 |
| SLC11A2 | EVPL | 0.738096 | 11 | 0 | 11 |
| SLC11A2 | CDS1 | 0.73718 | 11 | 0 | 11 |
| SLC11A2 | C15orf48 | 0.736848 | 7 | 0 | 7 |
| SLC11A2 | CHP1 | 0.736368 | 10 | 0 | 10 |
| SLC11A2 | ERBB3 | 0.730384 | 11 | 0 | 11 |
| SLC11A2 | ACPP | 0.729731 | 11 | 0 | 11 |
| SLC11A2 | CCNYL1 | 0.727753 | 4 | 0 | 4 |
| SLC11A2 | RBM47 | 0.725433 | 12 | 0 | 11 |
| SLC11A2 | CLIC3 | 0.725315 | 9 | 0 | 9 |
| SLC11A2 | IL1RN | 0.723108 | 11 | 0 | 11 |
| SLC11A2 | TTC22 | 0.722789 | 11 | 0 | 11 |
| SLC11A2 | ZDHHC20 | 0.722441 | 4 | 0 | 3 |
| SLC11A2 | CAPN14 | 0.721191 | 6 | 0 | 6 |
| SLC11A2 | SPAG17 | 0.720965 | 5 | 0 | 5 |
For details and further investigation, click here
