| Full name: dehydrogenase/reductase 11 | Alias Symbol: MGC4172|SDR24C1 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 79154 | HGNC ID: HGNC:28639 | Ensembl Gene: ENSG00000278535 | OMIM ID: 616159 |
| Drug and gene relationship at DGIdb | |||
Expression of DHRS11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHRS11 | 79154 | 218756_s_at | -0.9733 | 0.3168 | |
| GSE20347 | DHRS11 | 79154 | 218756_s_at | -0.9287 | 0.0001 | |
| GSE23400 | DHRS11 | 79154 | 218756_s_at | -0.3408 | 0.0002 | |
| GSE26886 | DHRS11 | 79154 | 218756_s_at | -1.5824 | 0.0000 | |
| GSE29001 | DHRS11 | 79154 | 218756_s_at | -0.8899 | 0.0005 | |
| GSE38129 | DHRS11 | 79154 | 218756_s_at | -0.6454 | 0.0007 | |
| GSE45670 | DHRS11 | 79154 | 218756_s_at | -0.5194 | 0.0291 | |
| GSE53622 | DHRS11 | 79154 | 57461 | -0.7231 | 0.0000 | |
| GSE53624 | DHRS11 | 79154 | 57461 | -0.7453 | 0.0000 | |
| GSE63941 | DHRS11 | 79154 | 218756_s_at | 1.5903 | 0.0409 | |
| GSE77861 | DHRS11 | 79154 | 218756_s_at | -0.4604 | 0.2624 | |
| GSE97050 | DHRS11 | 79154 | A_23_P27005 | -0.2223 | 0.4816 | |
| SRP007169 | DHRS11 | 79154 | RNAseq | -1.8611 | 0.0001 | |
| SRP008496 | DHRS11 | 79154 | RNAseq | -1.5937 | 0.0000 | |
| SRP064894 | DHRS11 | 79154 | RNAseq | -0.9217 | 0.0028 | |
| SRP133303 | DHRS11 | 79154 | RNAseq | -1.4101 | 0.0000 | |
| SRP159526 | DHRS11 | 79154 | RNAseq | -0.0942 | 0.6496 | |
| SRP193095 | DHRS11 | 79154 | RNAseq | -1.4777 | 0.0000 | |
| SRP219564 | DHRS11 | 79154 | RNAseq | -1.2868 | 0.0001 | |
| TCGA | DHRS11 | 79154 | RNAseq | -0.2407 | 0.0210 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by DHRS11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHRS11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHRS11 | 79154 | 5 | 1 | 24 | |
| GSE20123 | DHRS11 | 79154 | 5 | 1 | 24 | |
| GSE43470 | DHRS11 | 79154 | 1 | 2 | 40 | |
| GSE46452 | DHRS11 | 79154 | 34 | 0 | 25 | |
| GSE47630 | DHRS11 | 79154 | 8 | 1 | 31 | |
| GSE54993 | DHRS11 | 79154 | 3 | 3 | 64 | |
| GSE54994 | DHRS11 | 79154 | 8 | 6 | 39 | |
| GSE60625 | DHRS11 | 79154 | 4 | 0 | 7 | |
| GSE74703 | DHRS11 | 79154 | 1 | 1 | 34 | |
| GSE74704 | DHRS11 | 79154 | 3 | 1 | 16 | |
| TCGA | DHRS11 | 79154 | 19 | 9 | 68 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of DHRS11:
Generating mutation plots.
Highly correlated genes for DHRS11:
Showing top 20/759 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHRS11 | SMIM5 | 0.710184 | 5 | 0 | 5 |
| DHRS11 | VSIG2 | 0.708893 | 6 | 0 | 6 |
| DHRS11 | FAM3B | 0.699655 | 5 | 0 | 5 |
| DHRS11 | C15orf62 | 0.694414 | 5 | 0 | 5 |
| DHRS11 | CCNYL1 | 0.692864 | 3 | 0 | 3 |
| DHRS11 | MFAP3 | 0.689361 | 3 | 0 | 3 |
| DHRS11 | GCHFR | 0.683139 | 8 | 0 | 8 |
| DHRS11 | ZNF431 | 0.677823 | 4 | 0 | 4 |
| DHRS11 | SOX21-AS1 | 0.676395 | 4 | 0 | 3 |
| DHRS11 | LNX1 | 0.672486 | 4 | 0 | 4 |
| DHRS11 | TAB3 | 0.669967 | 5 | 0 | 4 |
| DHRS11 | AIF1L | 0.665561 | 7 | 0 | 7 |
| DHRS11 | TMPRSS2 | 0.662775 | 6 | 0 | 5 |
| DHRS11 | C15orf48 | 0.662274 | 5 | 0 | 5 |
| DHRS11 | SPINK7 | 0.662197 | 6 | 0 | 5 |
| DHRS11 | TYRO3 | 0.661974 | 11 | 0 | 10 |
| DHRS11 | OR2Z1 | 0.659925 | 3 | 0 | 3 |
| DHRS11 | IQCF1 | 0.655522 | 3 | 0 | 3 |
| DHRS11 | ARHGAP27 | 0.654436 | 6 | 0 | 5 |
| DHRS11 | ZNF681 | 0.65059 | 4 | 0 | 4 |
For details and further investigation, click here
