CTNNB1

 

Full name: catenin beta 1 Alias Symbol: beta-catenin|armadillo
Type: protein-coding gene Cytoband: 3p22.1
Entrez ID: 1499 HGNC ID: HGNC:2514 Ensembl Gene: ENSG00000168036 OMIM ID: 116806
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 40/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CTNNB1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04670Leukocyte transendothelial migration
hsa04916Melanogenesis
hsa04919Thyroid hormone signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma

 

Expression of CTNNB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTNNB1 1499 201533_at 0.0289 0.9550
GSE20347 CTNNB1 1499 201533_at -0.0358 0.8069
GSE23400 CTNNB1 1499 201533_at 0.1168 0.2055
GSE26886 CTNNB1 1499 201533_at -0.5881 0.0191
GSE29001 CTNNB1 1499 201533_at -0.3247 0.3179
GSE38129 CTNNB1 1499 201533_at 0.1648 0.1300
GSE45670 CTNNB1 1499 201533_at 0.0777 0.6080
GSE53622 CTNNB1 1499 54779 -0.0550 0.4713
GSE53624 CTNNB1 1499 42125 -0.0986 0.1179
GSE63941 CTNNB1 1499 201533_at -0.6134 0.5969
GSE77861 CTNNB1 1499 201533_at -0.0965 0.7686
GSE97050 CTNNB1 1499 A_33_P3421695 0.4559 0.2601
SRP007169 CTNNB1 1499 RNAseq 0.5620 0.1998
SRP008496 CTNNB1 1499 RNAseq 0.5827 0.0334
SRP064894 CTNNB1 1499 RNAseq -0.0275 0.8416
SRP133303 CTNNB1 1499 RNAseq 0.1173 0.1942
SRP159526 CTNNB1 1499 RNAseq 0.4679 0.0836
SRP193095 CTNNB1 1499 RNAseq -0.0505 0.6685
SRP219564 CTNNB1 1499 RNAseq -0.2104 0.2305
TCGA CTNNB1 1499 RNAseq 0.0422 0.3264

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CTNNB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTNNB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTNNB1 1499 0 19 11
GSE20123 CTNNB1 1499 0 19 11
GSE43470 CTNNB1 1499 0 20 23
GSE46452 CTNNB1 1499 2 17 40
GSE47630 CTNNB1 1499 2 24 14
GSE54993 CTNNB1 1499 7 2 61
GSE54994 CTNNB1 1499 2 32 19
GSE60625 CTNNB1 1499 5 0 6
GSE74703 CTNNB1 1499 0 16 20
GSE74704 CTNNB1 1499 0 13 7
TCGA CTNNB1 1499 2 71 23

Total number of gains: 20; Total number of losses: 233; Total Number of normals: 235.  

 

Somatic mutations of CTNNB1:

 

Generating mutation plots.

 

Highly correlated genes for CTNNB1:

 

Showing top 20/50 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTNNB1WDFY10.690343303
CTNNB1APPL10.645855303
CTNNB1ADAM100.642913303
CTNNB1VTA10.641101403
CTNNB1FANCD20.630737303
CTNNB1MAP70.623526504
CTNNB1CCDC1170.616846403
CTNNB1CTCF0.61672404
CTNNB1ROBO10.610148303
CTNNB1DKK10.606273403
CTNNB1ATG30.596666404
CTNNB1KIF110.574388503
CTNNB1CDV30.573944603
CTNNB1ENOPH10.570857303
CTNNB1PLIN20.564236303
CTNNB1PPM1A0.560342403
CTNNB1RPAP30.555157503
CTNNB1APPL20.553566303
CTNNB1SNAP230.552231605
CTNNB1PDSS20.54631604

For details and further investigation, click here