| Full name: deleted in lymphocytic leukemia 1 | Alias Symbol: LEU1|XTP6|NCRNA00021|LINC00021|BCMS1 | ||
| Type: non-coding RNA | Cytoband: 13q14.2-q14.3 | ||
| Entrez ID: 10301 | HGNC ID: HGNC:13747 | Ensembl Gene: ENSG00000176124 | OMIM ID: 605765 |
| Drug and gene relationship at DGIdb | |||
Expression of DLEU1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLEU1 | 10301 | 205677_s_at | -0.1884 | 0.6643 | |
| GSE20347 | DLEU1 | 10301 | 205677_s_at | -0.4955 | 0.0008 | |
| GSE23400 | DLEU1 | 10301 | 205677_s_at | -0.2701 | 0.0000 | |
| GSE26886 | DLEU1 | 10301 | 205677_s_at | -1.3115 | 0.0003 | |
| GSE29001 | DLEU1 | 10301 | 205677_s_at | -0.4122 | 0.1889 | |
| GSE38129 | DLEU1 | 10301 | 205677_s_at | -0.2554 | 0.1499 | |
| GSE45670 | DLEU1 | 10301 | 205677_s_at | -0.2168 | 0.1613 | |
| GSE53622 | DLEU1 | 10301 | 1602 | -0.4592 | 0.0000 | |
| GSE53624 | DLEU1 | 10301 | 48698 | -0.4449 | 0.0027 | |
| GSE63941 | DLEU1 | 10301 | 205677_s_at | 0.8536 | 0.1657 | |
| GSE77861 | DLEU1 | 10301 | 205677_s_at | -0.7006 | 0.0135 | |
| SRP007169 | DLEU1 | 10301 | RNAseq | -0.3832 | 0.5040 | |
| SRP008496 | DLEU1 | 10301 | RNAseq | 0.0230 | 0.9484 | |
| SRP064894 | DLEU1 | 10301 | RNAseq | -0.0219 | 0.9253 | |
| SRP133303 | DLEU1 | 10301 | RNAseq | 0.4006 | 0.0089 | |
| SRP159526 | DLEU1 | 10301 | RNAseq | -0.1867 | 0.5380 | |
| SRP193095 | DLEU1 | 10301 | RNAseq | 0.3242 | 0.0072 | |
| SRP219564 | DLEU1 | 10301 | RNAseq | -0.0393 | 0.8932 | |
| TCGA | DLEU1 | 10301 | RNAseq | 0.2491 | 0.0035 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DLEU1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLEU1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLEU1 | 10301 | 1 | 13 | 16 | |
| GSE20123 | DLEU1 | 10301 | 1 | 12 | 17 | |
| GSE43470 | DLEU1 | 10301 | 3 | 13 | 27 | |
| GSE46452 | DLEU1 | 10301 | 0 | 32 | 27 | |
| GSE47630 | DLEU1 | 10301 | 2 | 27 | 11 | |
| GSE54993 | DLEU1 | 10301 | 12 | 2 | 56 | |
| GSE54994 | DLEU1 | 10301 | 2 | 15 | 36 | |
| GSE60625 | DLEU1 | 10301 | 0 | 3 | 8 | |
| GSE74703 | DLEU1 | 10301 | 3 | 10 | 23 | |
| GSE74704 | DLEU1 | 10301 | 0 | 9 | 11 | |
| TCGA | DLEU1 | 10301 | 9 | 37 | 50 |
Total number of gains: 33; Total number of losses: 173; Total Number of normals: 282.
Somatic mutations of DLEU1:
Generating mutation plots.
Highly correlated genes for DLEU1:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLEU1 | ZNF70 | 0.661902 | 3 | 0 | 3 |
| DLEU1 | NIPSNAP3A | 0.654352 | 5 | 0 | 4 |
| DLEU1 | NDFIP2 | 0.645085 | 4 | 0 | 3 |
| DLEU1 | COG6 | 0.641054 | 6 | 0 | 4 |
| DLEU1 | TMEM125 | 0.638003 | 3 | 0 | 3 |
| DLEU1 | MTIF3 | 0.633816 | 3 | 0 | 3 |
| DLEU1 | EBPL | 0.633532 | 7 | 0 | 6 |
| DLEU1 | UBXN8 | 0.63137 | 4 | 0 | 4 |
| DLEU1 | NDUFA10 | 0.630114 | 6 | 0 | 5 |
| DLEU1 | LRP11 | 0.625721 | 3 | 0 | 3 |
| DLEU1 | TRIM6 | 0.621617 | 5 | 0 | 4 |
| DLEU1 | VSNL1 | 0.621478 | 4 | 0 | 3 |
| DLEU1 | UBAC2 | 0.619595 | 5 | 0 | 5 |
| DLEU1 | ZNF396 | 0.607502 | 3 | 0 | 3 |
| DLEU1 | ZNF823 | 0.607118 | 4 | 0 | 4 |
| DLEU1 | UBE2J1 | 0.606424 | 3 | 0 | 3 |
| DLEU1 | PPP1R11 | 0.605853 | 4 | 0 | 3 |
| DLEU1 | ARF4 | 0.601929 | 3 | 0 | 3 |
| DLEU1 | MRPL46 | 0.600949 | 5 | 0 | 3 |
| DLEU1 | ALG14 | 0.600709 | 5 | 0 | 4 |
For details and further investigation, click here
