| Full name: discs large MAGUK scaffold protein 1 | Alias Symbol: SAP97|SAP-97|hdlg|DLGH1|dJ1061C18.1.1 | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 1739 | HGNC ID: HGNC:2900 | Ensembl Gene: ENSG00000075711 | OMIM ID: 601014 |
| Drug and gene relationship at DGIdb | |||
DLG1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway | |
| hsa04660 | T cell receptor signaling pathway | |
| hsa05166 | HTLV-I infection |
Expression of DLG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLG1 | 1739 | 202515_at | -0.2556 | 0.5181 | |
| GSE20347 | DLG1 | 1739 | 202515_at | -0.2021 | 0.2011 | |
| GSE23400 | DLG1 | 1739 | 202515_at | -0.0887 | 0.2692 | |
| GSE26886 | DLG1 | 1739 | 202515_at | -1.1745 | 0.0000 | |
| GSE29001 | DLG1 | 1739 | 202515_at | -0.0899 | 0.7729 | |
| GSE38129 | DLG1 | 1739 | 202515_at | -0.0692 | 0.7203 | |
| GSE45670 | DLG1 | 1739 | 202515_at | -0.0382 | 0.8826 | |
| GSE53622 | DLG1 | 1739 | 24282 | -0.1811 | 0.0185 | |
| GSE53624 | DLG1 | 1739 | 96339 | -0.1341 | 0.0712 | |
| GSE63941 | DLG1 | 1739 | 202515_at | 0.5219 | 0.2009 | |
| GSE77861 | DLG1 | 1739 | 202515_at | -0.3193 | 0.1547 | |
| GSE97050 | DLG1 | 1739 | A_33_P3224380 | -0.1194 | 0.6980 | |
| SRP007169 | DLG1 | 1739 | RNAseq | 0.0532 | 0.8734 | |
| SRP008496 | DLG1 | 1739 | RNAseq | 0.3071 | 0.2103 | |
| SRP064894 | DLG1 | 1739 | RNAseq | -0.4143 | 0.1270 | |
| SRP133303 | DLG1 | 1739 | RNAseq | -0.0965 | 0.6029 | |
| SRP159526 | DLG1 | 1739 | RNAseq | -0.1091 | 0.7283 | |
| SRP193095 | DLG1 | 1739 | RNAseq | -0.5440 | 0.0007 | |
| SRP219564 | DLG1 | 1739 | RNAseq | -0.4555 | 0.3054 | |
| TCGA | DLG1 | 1739 | RNAseq | 0.0481 | 0.3934 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DLG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLG1 | 1739 | 23 | 0 | 7 | |
| GSE20123 | DLG1 | 1739 | 23 | 0 | 7 | |
| GSE43470 | DLG1 | 1739 | 21 | 0 | 22 | |
| GSE46452 | DLG1 | 1739 | 20 | 1 | 38 | |
| GSE47630 | DLG1 | 1739 | 27 | 2 | 11 | |
| GSE54993 | DLG1 | 1739 | 1 | 22 | 47 | |
| GSE54994 | DLG1 | 1739 | 41 | 0 | 12 | |
| GSE60625 | DLG1 | 1739 | 0 | 6 | 5 | |
| GSE74703 | DLG1 | 1739 | 19 | 0 | 17 | |
| GSE74704 | DLG1 | 1739 | 14 | 0 | 6 | |
| TCGA | DLG1 | 1739 | 76 | 1 | 19 |
Total number of gains: 265; Total number of losses: 32; Total Number of normals: 191.
Somatic mutations of DLG1:
Generating mutation plots.
Highly correlated genes for DLG1:
Showing top 20/632 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLG1 | ARFIP1 | 0.826448 | 3 | 0 | 3 |
| DLG1 | ZFAND6 | 0.743432 | 3 | 0 | 3 |
| DLG1 | CHIC2 | 0.738298 | 4 | 0 | 4 |
| DLG1 | TAB3 | 0.735722 | 4 | 0 | 4 |
| DLG1 | SPCS1 | 0.733427 | 3 | 0 | 3 |
| DLG1 | TRERF1 | 0.728017 | 4 | 0 | 4 |
| DLG1 | ELMO2 | 0.727796 | 3 | 0 | 3 |
| DLG1 | PPM1K | 0.71383 | 3 | 0 | 3 |
| DLG1 | GTF2A1 | 0.713442 | 3 | 0 | 3 |
| DLG1 | HIBCH | 0.711776 | 4 | 0 | 3 |
| DLG1 | PNRC2 | 0.710142 | 3 | 0 | 3 |
| DLG1 | FEM1A | 0.709155 | 3 | 0 | 3 |
| DLG1 | SUCLG2 | 0.707224 | 3 | 0 | 3 |
| DLG1 | GPD1L | 0.705543 | 3 | 0 | 3 |
| DLG1 | ITPR2 | 0.704135 | 3 | 0 | 3 |
| DLG1 | BECN1 | 0.702508 | 3 | 0 | 3 |
| DLG1 | UBE2J1 | 0.69148 | 3 | 0 | 3 |
| DLG1 | FBXO9 | 0.691007 | 3 | 0 | 3 |
| DLG1 | HIGD1A | 0.688252 | 3 | 0 | 3 |
| DLG1 | SLC10A7 | 0.68674 | 3 | 0 | 3 |
For details and further investigation, click here
