| Full name: nitric oxide synthase 1 adaptor protein | Alias Symbol: KIAA0464|CAPON | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 9722 | HGNC ID: HGNC:16859 | Ensembl Gene: ENSG00000198929 | OMIM ID: 605551 |
| Drug and gene relationship at DGIdb | |||
NOS1AP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04713 | Circadian entrainment |
Expression of NOS1AP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOS1AP | 9722 | 215153_at | 0.4387 | 0.3480 | |
| GSE20347 | NOS1AP | 9722 | 215153_at | 0.3503 | 0.0359 | |
| GSE23400 | NOS1AP | 9722 | 215153_at | 0.1319 | 0.0197 | |
| GSE26886 | NOS1AP | 9722 | 215153_at | -0.1042 | 0.4059 | |
| GSE29001 | NOS1AP | 9722 | 215153_at | 0.2123 | 0.4662 | |
| GSE38129 | NOS1AP | 9722 | 215153_at | 0.4244 | 0.0098 | |
| GSE45670 | NOS1AP | 9722 | 215153_at | 0.3897 | 0.0352 | |
| GSE53622 | NOS1AP | 9722 | 51310 | 0.8252 | 0.0001 | |
| GSE53624 | NOS1AP | 9722 | 151717 | 1.1569 | 0.0000 | |
| GSE63941 | NOS1AP | 9722 | 215153_at | 0.3110 | 0.4033 | |
| GSE77861 | NOS1AP | 9722 | 1563512_at | 0.0191 | 0.8771 | |
| GSE97050 | NOS1AP | 9722 | A_23_P74309 | -0.2528 | 0.6414 | |
| SRP007169 | NOS1AP | 9722 | RNAseq | 3.8613 | 0.0014 | |
| SRP133303 | NOS1AP | 9722 | RNAseq | 0.8678 | 0.0616 | |
| SRP159526 | NOS1AP | 9722 | RNAseq | 2.2127 | 0.0000 | |
| SRP193095 | NOS1AP | 9722 | RNAseq | 1.2665 | 0.0001 | |
| SRP219564 | NOS1AP | 9722 | RNAseq | 0.2903 | 0.6773 | |
| TCGA | NOS1AP | 9722 | RNAseq | -0.4271 | 0.0307 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by NOS1AP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOS1AP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOS1AP | 9722 | 10 | 0 | 20 | |
| GSE20123 | NOS1AP | 9722 | 10 | 0 | 20 | |
| GSE43470 | NOS1AP | 9722 | 7 | 2 | 34 | |
| GSE46452 | NOS1AP | 9722 | 2 | 1 | 56 | |
| GSE47630 | NOS1AP | 9722 | 14 | 0 | 26 | |
| GSE54993 | NOS1AP | 9722 | 0 | 5 | 65 | |
| GSE54994 | NOS1AP | 9722 | 16 | 0 | 37 | |
| GSE60625 | NOS1AP | 9722 | 0 | 0 | 11 | |
| GSE74703 | NOS1AP | 9722 | 7 | 2 | 27 | |
| GSE74704 | NOS1AP | 9722 | 4 | 0 | 16 | |
| TCGA | NOS1AP | 9722 | 43 | 6 | 47 |
Total number of gains: 113; Total number of losses: 16; Total Number of normals: 359.
Somatic mutations of NOS1AP:
Generating mutation plots.
Highly correlated genes for NOS1AP:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOS1AP | C1orf226 | 0.760375 | 4 | 0 | 4 |
| NOS1AP | ATP6V1E2 | 0.734329 | 3 | 0 | 3 |
| NOS1AP | DLX3 | 0.7093 | 3 | 0 | 3 |
| NOS1AP | CPT1A | 0.699766 | 3 | 0 | 3 |
| NOS1AP | CLASP1 | 0.693281 | 3 | 0 | 3 |
| NOS1AP | NES | 0.685739 | 3 | 0 | 3 |
| NOS1AP | ZNF445 | 0.683172 | 3 | 0 | 3 |
| NOS1AP | MAPK11 | 0.678135 | 3 | 0 | 3 |
| NOS1AP | PHLDA2 | 0.662583 | 3 | 0 | 3 |
| NOS1AP | DNALI1 | 0.658699 | 3 | 0 | 3 |
| NOS1AP | MPG | 0.64872 | 3 | 0 | 3 |
| NOS1AP | KCTD2 | 0.64776 | 3 | 0 | 3 |
| NOS1AP | RHOBTB2 | 0.645899 | 3 | 0 | 3 |
| NOS1AP | PTDSS2 | 0.644747 | 3 | 0 | 3 |
| NOS1AP | NRL | 0.637182 | 3 | 0 | 3 |
| NOS1AP | RAB35 | 0.635962 | 3 | 0 | 3 |
| NOS1AP | VAPB | 0.629666 | 4 | 0 | 3 |
| NOS1AP | OGDH | 0.627783 | 4 | 0 | 3 |
| NOS1AP | INO80B | 0.627206 | 4 | 0 | 3 |
| NOS1AP | IFFO2 | 0.627119 | 4 | 0 | 3 |
For details and further investigation, click here
