| Full name: sialic acid binding Ig like lectin 12 (gene/pseudogene) | Alias Symbol: SLG|S2V|Siglec-XII|Siglec-12|Siglec-L1 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 89858 | HGNC ID: HGNC:15482 | Ensembl Gene: ENSG00000254521 | OMIM ID: 606094 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SIGLEC12 | 89858 | 90904 | 1.3661 | 0.0000 | |
| GSE53624 | SIGLEC12 | 89858 | 90904 | 1.2555 | 0.0000 | |
| GSE97050 | SIGLEC12 | 89858 | A_23_P164596 | 0.6203 | 0.3484 | |
| SRP133303 | SIGLEC12 | 89858 | RNAseq | 2.6036 | 0.0000 | |
| TCGA | SIGLEC12 | 89858 | RNAseq | 1.8885 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SIGLEC12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC12 | 89858 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC12 | 89858 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC12 | 89858 | 3 | 12 | 28 | |
| GSE46452 | SIGLEC12 | 89858 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC12 | 89858 | 9 | 6 | 25 | |
| GSE54993 | SIGLEC12 | 89858 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC12 | 89858 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC12 | 89858 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC12 | 89858 | 3 | 8 | 25 | |
| GSE74704 | SIGLEC12 | 89858 | 3 | 1 | 16 | |
| TCGA | SIGLEC12 | 89858 | 14 | 19 | 63 |
Total number of gains: 113; Total number of losses: 72; Total Number of normals: 303.
Somatic mutations of SIGLEC12:
Generating mutation plots.
Highly correlated genes for SIGLEC12:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC12 | CD300C | 0.728908 | 3 | 0 | 3 |
| SIGLEC12 | SLAMF8 | 0.720016 | 3 | 0 | 3 |
| SIGLEC12 | IL4I1 | 0.707518 | 3 | 0 | 3 |
| SIGLEC12 | C2 | 0.707516 | 3 | 0 | 3 |
| SIGLEC12 | RNASE2 | 0.699773 | 3 | 0 | 3 |
| SIGLEC12 | FPR3 | 0.689862 | 3 | 0 | 3 |
| SIGLEC12 | SLC7A7 | 0.687723 | 3 | 0 | 3 |
| SIGLEC12 | PLA2G7 | 0.674948 | 3 | 0 | 3 |
| SIGLEC12 | GPR84 | 0.671117 | 3 | 0 | 3 |
| SIGLEC12 | PLXNC1 | 0.668965 | 3 | 0 | 3 |
| SIGLEC12 | CCR1 | 0.666465 | 3 | 0 | 3 |
| SIGLEC12 | CCR8 | 0.663432 | 3 | 0 | 3 |
| SIGLEC12 | IFIT3 | 0.662791 | 3 | 0 | 3 |
| SIGLEC12 | LRRC25 | 0.658909 | 3 | 0 | 3 |
| SIGLEC12 | DOK2 | 0.648864 | 3 | 0 | 3 |
| SIGLEC12 | P2RY6 | 0.644423 | 3 | 0 | 3 |
| SIGLEC12 | UBE2L6 | 0.643278 | 3 | 0 | 3 |
| SIGLEC12 | PDCD1LG2 | 0.641507 | 3 | 0 | 3 |
| SIGLEC12 | LILRB4 | 0.637342 | 3 | 0 | 3 |
| SIGLEC12 | TMEM150B | 0.635306 | 3 | 0 | 3 |
For details and further investigation, click here
