PFDN4

 

Full name: prefoldin subunit 4 Alias Symbol: PFD4|C-1|C1
Type: protein-coding gene Cytoband: 20q13.2
Entrez ID: 5203 HGNC ID: HGNC:8868 Ensembl Gene: ENSG00000101132 OMIM ID: 604898
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PFDN4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PFDN4 5203 205361_s_at 0.7185 0.0908
GSE20347 PFDN4 5203 205361_s_at 0.5734 0.0071
GSE23400 PFDN4 5203 205361_s_at 0.8598 0.0000
GSE26886 PFDN4 5203 205361_s_at 1.1758 0.0000
GSE29001 PFDN4 5203 205361_s_at 0.5949 0.1937
GSE38129 PFDN4 5203 205361_s_at 0.5671 0.0003
GSE45670 PFDN4 5203 205361_s_at 0.4825 0.0010
GSE53622 PFDN4 5203 11551 0.7726 0.0000
GSE53624 PFDN4 5203 11551 0.8399 0.0000
GSE63941 PFDN4 5203 205361_s_at 0.5276 0.1357
GSE77861 PFDN4 5203 205361_s_at 0.5960 0.0296
GSE97050 PFDN4 5203 A_23_P166023 0.6649 0.1778
SRP007169 PFDN4 5203 RNAseq 0.0641 0.8743
SRP008496 PFDN4 5203 RNAseq 0.0289 0.9214
SRP064894 PFDN4 5203 RNAseq 0.5923 0.0131
SRP133303 PFDN4 5203 RNAseq 0.8693 0.0000
SRP159526 PFDN4 5203 RNAseq 0.5768 0.0538
SRP193095 PFDN4 5203 RNAseq 0.1299 0.4018
SRP219564 PFDN4 5203 RNAseq 0.2421 0.4806
TCGA PFDN4 5203 RNAseq 0.4215 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PFDN4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PFDN4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PFDN4 5203 15 1 14
GSE20123 PFDN4 5203 16 1 13
GSE43470 PFDN4 5203 14 0 29
GSE46452 PFDN4 5203 29 0 30
GSE47630 PFDN4 5203 24 1 15
GSE54993 PFDN4 5203 0 17 53
GSE54994 PFDN4 5203 27 0 26
GSE60625 PFDN4 5203 0 0 11
GSE74703 PFDN4 5203 11 0 25
GSE74704 PFDN4 5203 12 0 8
TCGA PFDN4 5203 45 3 48

Total number of gains: 193; Total number of losses: 23; Total Number of normals: 272.  

 

Somatic mutations of PFDN4:

 

Generating mutation plots.

 

Highly correlated genes for PFDN4:

 

Showing top 20/1490 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PFDN4DPM10.75267511011
PFDN4SNRPB20.73455611011
PFDN4MRGBP0.72947810010
PFDN4SLC7A6OS0.713861404
PFDN4CSTF10.71314212012
PFDN4CSE1L0.71202911010
PFDN4SPATC1L0.694405303
PFDN4YTHDF10.6940471009
PFDN4DNTTIP10.690686808
PFDN4CEP890.689264303
PFDN4SLC39A100.688191505
PFDN4MRPS230.685243807
PFDN4PRIM20.68154810010
PFDN4RUVBL10.67533512011
PFDN4MND10.673188807
PFDN4CDCA20.671697505
PFDN4CMSS10.67033706
PFDN4UCK20.670006303
PFDN4PSMA70.66938812010
PFDN4GPR1580.668438605

For details and further investigation, click here