| Full name: dipeptidyl peptidase 8 | Alias Symbol: DP8|DPRP1|MSTP141|FLJ14920|FLJ20283|MGC26191 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 54878 | HGNC ID: HGNC:16490 | Ensembl Gene: ENSG00000074603 | OMIM ID: 606819 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DPP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPP8 | 54878 | 220939_s_at | -0.2010 | 0.5097 | |
| GSE20347 | DPP8 | 54878 | 220939_s_at | 0.0242 | 0.8787 | |
| GSE23400 | DPP8 | 54878 | 220939_s_at | 0.0471 | 0.5545 | |
| GSE26886 | DPP8 | 54878 | 220939_s_at | 0.3385 | 0.2447 | |
| GSE29001 | DPP8 | 54878 | 220939_s_at | 0.0536 | 0.8792 | |
| GSE38129 | DPP8 | 54878 | 220939_s_at | -0.0367 | 0.7755 | |
| GSE45670 | DPP8 | 54878 | 220939_s_at | -0.2908 | 0.0082 | |
| GSE53622 | DPP8 | 54878 | 67850 | -0.1118 | 0.0299 | |
| GSE53624 | DPP8 | 54878 | 67850 | -0.0934 | 0.1272 | |
| GSE63941 | DPP8 | 54878 | 220939_s_at | -0.6107 | 0.0446 | |
| GSE77861 | DPP8 | 54878 | 220939_s_at | 0.3802 | 0.0896 | |
| GSE97050 | DPP8 | 54878 | A_33_P3577671 | -0.2231 | 0.2889 | |
| SRP007169 | DPP8 | 54878 | RNAseq | -0.1462 | 0.7114 | |
| SRP008496 | DPP8 | 54878 | RNAseq | -0.0613 | 0.7537 | |
| SRP064894 | DPP8 | 54878 | RNAseq | -0.0978 | 0.6313 | |
| SRP133303 | DPP8 | 54878 | RNAseq | 0.0112 | 0.9279 | |
| SRP159526 | DPP8 | 54878 | RNAseq | -0.5587 | 0.0685 | |
| SRP193095 | DPP8 | 54878 | RNAseq | -0.1380 | 0.0403 | |
| SRP219564 | DPP8 | 54878 | RNAseq | -0.1029 | 0.6975 | |
| TCGA | DPP8 | 54878 | RNAseq | -0.0977 | 0.0533 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DPP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPP8 | 54878 | 7 | 3 | 20 | |
| GSE20123 | DPP8 | 54878 | 7 | 3 | 20 | |
| GSE43470 | DPP8 | 54878 | 4 | 6 | 33 | |
| GSE46452 | DPP8 | 54878 | 3 | 7 | 49 | |
| GSE47630 | DPP8 | 54878 | 8 | 10 | 22 | |
| GSE54993 | DPP8 | 54878 | 5 | 6 | 59 | |
| GSE54994 | DPP8 | 54878 | 6 | 7 | 40 | |
| GSE60625 | DPP8 | 54878 | 4 | 0 | 7 | |
| GSE74703 | DPP8 | 54878 | 4 | 3 | 29 | |
| GSE74704 | DPP8 | 54878 | 3 | 3 | 14 | |
| TCGA | DPP8 | 54878 | 10 | 16 | 70 |
Total number of gains: 61; Total number of losses: 64; Total Number of normals: 363.
Somatic mutations of DPP8:
Generating mutation plots.
Highly correlated genes for DPP8:
Showing top 20/354 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPP8 | RBBP4 | 0.728001 | 3 | 0 | 3 |
| DPP8 | SENP8 | 0.696094 | 3 | 0 | 3 |
| DPP8 | ZBED5 | 0.691928 | 4 | 0 | 4 |
| DPP8 | CHL1 | 0.691233 | 4 | 0 | 3 |
| DPP8 | PCBP2 | 0.689936 | 5 | 0 | 4 |
| DPP8 | ITGB1 | 0.684557 | 3 | 0 | 3 |
| DPP8 | FAU | 0.684506 | 3 | 0 | 3 |
| DPP8 | THAP4 | 0.682321 | 3 | 0 | 3 |
| DPP8 | TMEM109 | 0.681479 | 3 | 0 | 3 |
| DPP8 | SH3D19 | 0.666689 | 4 | 0 | 3 |
| DPP8 | CCNT1 | 0.663503 | 3 | 0 | 3 |
| DPP8 | ZNF25 | 0.661612 | 5 | 0 | 4 |
| DPP8 | RASSF3 | 0.661406 | 4 | 0 | 3 |
| DPP8 | RYBP | 0.661183 | 3 | 0 | 3 |
| DPP8 | ANPEP | 0.660625 | 3 | 0 | 3 |
| DPP8 | NFE2L1 | 0.659948 | 4 | 0 | 3 |
| DPP8 | GATAD1 | 0.658858 | 4 | 0 | 3 |
| DPP8 | INTS12 | 0.656698 | 3 | 0 | 3 |
| DPP8 | XPO4 | 0.655098 | 4 | 0 | 3 |
| DPP8 | CDC40 | 0.654902 | 4 | 0 | 4 |
For details and further investigation, click here
