| Full name: dual oxidase 2 | Alias Symbol: P138-TOX|P138(TOX)|THOX2|LNOX2 | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 50506 | HGNC ID: HGNC:13273 | Ensembl Gene: ENSG00000140279 | OMIM ID: 606759 |
| Drug and gene relationship at DGIdb | |||
DUOX2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04918 | Thyroid hormone synthesis |
Expression of DUOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUOX2 | 50506 | 219727_at | -0.4391 | 0.8264 | |
| GSE20347 | DUOX2 | 50506 | 219727_at | -0.8445 | 0.0682 | |
| GSE23400 | DUOX2 | 50506 | 219727_at | -0.7380 | 0.0001 | |
| GSE26886 | DUOX2 | 50506 | 219727_at | -2.7797 | 0.0000 | |
| GSE29001 | DUOX2 | 50506 | 219727_at | -0.9901 | 0.1057 | |
| GSE38129 | DUOX2 | 50506 | 219727_at | -0.8749 | 0.0222 | |
| GSE45670 | DUOX2 | 50506 | 219727_at | 1.0724 | 0.0539 | |
| GSE53622 | DUOX2 | 50506 | 49727 | -1.2742 | 0.0004 | |
| GSE53624 | DUOX2 | 50506 | 49727 | -1.6897 | 0.0000 | |
| GSE63941 | DUOX2 | 50506 | 219727_at | 1.0641 | 0.2115 | |
| GSE77861 | DUOX2 | 50506 | 219727_at | -1.0945 | 0.0672 | |
| GSE97050 | DUOX2 | 50506 | A_23_P151851 | 0.1802 | 0.4907 | |
| SRP007169 | DUOX2 | 50506 | RNAseq | -2.4297 | 0.0072 | |
| SRP008496 | DUOX2 | 50506 | RNAseq | -3.3749 | 0.0000 | |
| SRP064894 | DUOX2 | 50506 | RNAseq | -0.8866 | 0.0648 | |
| SRP133303 | DUOX2 | 50506 | RNAseq | -0.0332 | 0.9530 | |
| SRP159526 | DUOX2 | 50506 | RNAseq | -2.8441 | 0.0001 | |
| SRP193095 | DUOX2 | 50506 | RNAseq | -0.6987 | 0.1236 | |
| SRP219564 | DUOX2 | 50506 | RNAseq | -1.4177 | 0.1786 | |
| TCGA | DUOX2 | 50506 | RNAseq | -0.4617 | 0.0253 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by DUOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUOX2 | 50506 | 3 | 5 | 22 | |
| GSE20123 | DUOX2 | 50506 | 3 | 5 | 22 | |
| GSE43470 | DUOX2 | 50506 | 4 | 4 | 35 | |
| GSE46452 | DUOX2 | 50506 | 3 | 7 | 49 | |
| GSE47630 | DUOX2 | 50506 | 8 | 10 | 22 | |
| GSE54993 | DUOX2 | 50506 | 5 | 5 | 60 | |
| GSE54994 | DUOX2 | 50506 | 5 | 7 | 41 | |
| GSE60625 | DUOX2 | 50506 | 4 | 0 | 7 | |
| GSE74703 | DUOX2 | 50506 | 4 | 3 | 29 | |
| GSE74704 | DUOX2 | 50506 | 1 | 3 | 16 | |
| TCGA | DUOX2 | 50506 | 11 | 16 | 69 |
Total number of gains: 51; Total number of losses: 65; Total Number of normals: 372.
Somatic mutations of DUOX2:
Generating mutation plots.
Highly correlated genes for DUOX2:
Showing top 20/780 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUOX2 | ANKRD22 | 0.742931 | 4 | 0 | 4 |
| DUOX2 | FAM3B | 0.708627 | 5 | 0 | 5 |
| DUOX2 | FUT3 | 0.696462 | 11 | 0 | 11 |
| DUOX2 | LIPH | 0.692845 | 6 | 0 | 6 |
| DUOX2 | TMEM45B | 0.690794 | 7 | 0 | 7 |
| DUOX2 | LCN2 | 0.688328 | 11 | 0 | 9 |
| DUOX2 | ST6GALNAC1 | 0.680796 | 7 | 0 | 6 |
| DUOX2 | PSMC6 | 0.677998 | 3 | 0 | 3 |
| DUOX2 | MYO5B | 0.674658 | 5 | 0 | 5 |
| DUOX2 | FRMD6 | 0.673935 | 3 | 0 | 3 |
| DUOX2 | BCAS1 | 0.671847 | 11 | 0 | 10 |
| DUOX2 | COMMD8 | 0.671797 | 3 | 0 | 3 |
| DUOX2 | TTC9 | 0.671004 | 10 | 0 | 10 |
| DUOX2 | ABHD17C | 0.670054 | 5 | 0 | 5 |
| DUOX2 | DUOX1 | 0.667798 | 13 | 0 | 12 |
| DUOX2 | FAM3D | 0.666699 | 7 | 0 | 7 |
| DUOX2 | KIF21A | 0.666339 | 3 | 0 | 3 |
| DUOX2 | MUC20 | 0.665677 | 7 | 0 | 6 |
| DUOX2 | GPT2 | 0.663565 | 5 | 0 | 5 |
| DUOX2 | GLTP | 0.662697 | 9 | 0 | 8 |
For details and further investigation, click here
