| Full name: lipocalin 2 | Alias Symbol: NGAL|24p3 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 3934 | HGNC ID: HGNC:6526 | Ensembl Gene: ENSG00000148346 | OMIM ID: 600181 |
| Drug and gene relationship at DGIdb | |||
Expression of LCN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCN2 | 3934 | 212531_at | -1.8367 | 0.4443 | |
| GSE20347 | LCN2 | 3934 | 212531_at | -2.2663 | 0.0005 | |
| GSE23400 | LCN2 | 3934 | 212531_at | -2.0332 | 0.0000 | |
| GSE26886 | LCN2 | 3934 | 212531_at | -4.3830 | 0.0000 | |
| GSE29001 | LCN2 | 3934 | 212531_at | -2.9575 | 0.0064 | |
| GSE38129 | LCN2 | 3934 | 212531_at | -1.6186 | 0.0129 | |
| GSE45670 | LCN2 | 3934 | 212531_at | 0.2348 | 0.6400 | |
| GSE53622 | LCN2 | 3934 | 104320 | -2.1110 | 0.0000 | |
| GSE53624 | LCN2 | 3934 | 104320 | -2.8562 | 0.0000 | |
| GSE63941 | LCN2 | 3934 | 212531_at | 4.4637 | 0.0451 | |
| GSE77861 | LCN2 | 3934 | 212531_at | -0.7837 | 0.1616 | |
| GSE97050 | LCN2 | 3934 | A_23_P169437 | 0.3188 | 0.8080 | |
| SRP007169 | LCN2 | 3934 | RNAseq | -2.8785 | 0.0005 | |
| SRP008496 | LCN2 | 3934 | RNAseq | -2.8665 | 0.0002 | |
| SRP064894 | LCN2 | 3934 | RNAseq | -2.1367 | 0.0023 | |
| SRP133303 | LCN2 | 3934 | RNAseq | -1.7996 | 0.0000 | |
| SRP159526 | LCN2 | 3934 | RNAseq | -2.7532 | 0.0004 | |
| SRP193095 | LCN2 | 3934 | RNAseq | -1.6477 | 0.0001 | |
| SRP219564 | LCN2 | 3934 | RNAseq | -1.8354 | 0.1439 | |
| TCGA | LCN2 | 3934 | RNAseq | 0.2929 | 0.2161 |
Upregulated datasets: 1; Downregulated datasets: 13.
Survival by LCN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCN2 | 3934 | 6 | 9 | 15 | |
| GSE20123 | LCN2 | 3934 | 6 | 9 | 15 | |
| GSE43470 | LCN2 | 3934 | 5 | 7 | 31 | |
| GSE46452 | LCN2 | 3934 | 6 | 13 | 40 | |
| GSE47630 | LCN2 | 3934 | 3 | 16 | 21 | |
| GSE54993 | LCN2 | 3934 | 3 | 3 | 64 | |
| GSE54994 | LCN2 | 3934 | 11 | 8 | 34 | |
| GSE60625 | LCN2 | 3934 | 0 | 0 | 11 | |
| GSE74703 | LCN2 | 3934 | 5 | 5 | 26 | |
| GSE74704 | LCN2 | 3934 | 3 | 7 | 10 | |
| TCGA | LCN2 | 3934 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 102; Total Number of normals: 311.
Somatic mutations of LCN2:
Generating mutation plots.
Highly correlated genes for LCN2:
Showing top 20/949 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCN2 | IL20RB | 0.776482 | 5 | 0 | 5 |
| LCN2 | PGLYRP3 | 0.768888 | 4 | 0 | 4 |
| LCN2 | ITGAD | 0.761199 | 4 | 0 | 4 |
| LCN2 | SPRR2D | 0.759738 | 4 | 0 | 4 |
| LCN2 | PDZK1IP1 | 0.758705 | 12 | 0 | 12 |
| LCN2 | SPRR2F | 0.74628 | 4 | 0 | 4 |
| LCN2 | SPRR2E | 0.743916 | 4 | 0 | 4 |
| LCN2 | FUT3 | 0.743551 | 12 | 0 | 12 |
| LCN2 | SH3RF2 | 0.742458 | 6 | 0 | 6 |
| LCN2 | ELF3 | 0.738605 | 12 | 0 | 11 |
| LCN2 | KRT80 | 0.738581 | 7 | 0 | 7 |
| LCN2 | TMPRSS11E | 0.734216 | 12 | 0 | 10 |
| LCN2 | BNIPL | 0.729664 | 5 | 0 | 5 |
| LCN2 | SPRR2A | 0.729565 | 4 | 0 | 4 |
| LCN2 | CRABP2 | 0.723796 | 9 | 0 | 9 |
| LCN2 | PRDM1 | 0.71628 | 10 | 0 | 10 |
| LCN2 | TMPRSS11D | 0.711366 | 12 | 0 | 9 |
| LCN2 | SERPINB3 | 0.710539 | 11 | 0 | 8 |
| LCN2 | SPRR2B | 0.710173 | 4 | 0 | 4 |
| LCN2 | S100A9 | 0.709263 | 12 | 0 | 10 |
For details and further investigation, click here
