| Full name: ectodermal-neural cortex 1 | Alias Symbol: PIG10|ENC-1|TP53I10|KLHL37 | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 8507 | HGNC ID: HGNC:3345 | Ensembl Gene: ENSG00000171617 | OMIM ID: 605173 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ENC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENC1 | 8507 | 201341_at | 0.7711 | 0.2370 | |
| GSE20347 | ENC1 | 8507 | 201341_at | 0.4049 | 0.1803 | |
| GSE23400 | ENC1 | 8507 | 201341_at | 0.2739 | 0.0001 | |
| GSE26886 | ENC1 | 8507 | 201341_at | -1.1587 | 0.0000 | |
| GSE29001 | ENC1 | 8507 | 201341_at | -0.1277 | 0.7261 | |
| GSE38129 | ENC1 | 8507 | 201341_at | 0.5205 | 0.0268 | |
| GSE45670 | ENC1 | 8507 | 201341_at | 0.1786 | 0.5816 | |
| GSE63941 | ENC1 | 8507 | 201341_at | -0.6603 | 0.5676 | |
| GSE77861 | ENC1 | 8507 | 201341_at | -0.1505 | 0.6108 | |
| GSE97050 | ENC1 | 8507 | A_24_P69095 | 0.7585 | 0.0863 | |
| SRP007169 | ENC1 | 8507 | RNAseq | 0.9077 | 0.0077 | |
| SRP008496 | ENC1 | 8507 | RNAseq | 1.2179 | 0.0000 | |
| SRP064894 | ENC1 | 8507 | RNAseq | 1.5529 | 0.0000 | |
| SRP133303 | ENC1 | 8507 | RNAseq | 1.1707 | 0.0000 | |
| SRP193095 | ENC1 | 8507 | RNAseq | 0.6204 | 0.0638 | |
| SRP219564 | ENC1 | 8507 | RNAseq | 1.7994 | 0.0000 | |
| TCGA | ENC1 | 8507 | RNAseq | -0.3061 | 0.0042 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by ENC1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ENC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENC1 | 8507 | 1 | 13 | 16 | |
| GSE20123 | ENC1 | 8507 | 1 | 13 | 16 | |
| GSE43470 | ENC1 | 8507 | 1 | 13 | 29 | |
| GSE46452 | ENC1 | 8507 | 0 | 28 | 31 | |
| GSE47630 | ENC1 | 8507 | 1 | 19 | 20 | |
| GSE54993 | ENC1 | 8507 | 8 | 1 | 61 | |
| GSE54994 | ENC1 | 8507 | 1 | 19 | 33 | |
| GSE60625 | ENC1 | 8507 | 0 | 0 | 11 | |
| GSE74703 | ENC1 | 8507 | 1 | 9 | 26 | |
| GSE74704 | ENC1 | 8507 | 1 | 6 | 13 | |
| TCGA | ENC1 | 8507 | 5 | 50 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of ENC1:
Generating mutation plots.
Highly correlated genes for ENC1:
Showing top 20/141 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENC1 | SYTL4 | 0.806394 | 3 | 0 | 3 |
| ENC1 | LMAN1 | 0.790939 | 3 | 0 | 3 |
| ENC1 | MEX3B | 0.739975 | 3 | 0 | 3 |
| ENC1 | ALPK2 | 0.732179 | 4 | 0 | 4 |
| ENC1 | AP1G1 | 0.724552 | 3 | 0 | 3 |
| ENC1 | PRRC1 | 0.721277 | 3 | 0 | 3 |
| ENC1 | NFKB1 | 0.721165 | 3 | 0 | 3 |
| ENC1 | TTC31 | 0.719109 | 3 | 0 | 3 |
| ENC1 | AGBL5 | 0.71462 | 3 | 0 | 3 |
| ENC1 | COL8A2 | 0.713102 | 3 | 0 | 3 |
| ENC1 | RHBDF1 | 0.710421 | 3 | 0 | 3 |
| ENC1 | C6orf62 | 0.705387 | 3 | 0 | 3 |
| ENC1 | ZFR | 0.693692 | 3 | 0 | 3 |
| ENC1 | IFNAR1 | 0.69203 | 3 | 0 | 3 |
| ENC1 | ATP6V1B2 | 0.690598 | 4 | 0 | 3 |
| ENC1 | PAK2 | 0.689545 | 3 | 0 | 3 |
| ENC1 | SPAG1 | 0.68474 | 3 | 0 | 3 |
| ENC1 | MCCC2 | 0.681451 | 3 | 0 | 3 |
| ENC1 | KIF3C | 0.68081 | 5 | 0 | 5 |
| ENC1 | BZW1 | 0.680728 | 3 | 0 | 3 |
For details and further investigation, click here
