POLE2

 

Full name: DNA polymerase epsilon 2, accessory subunit Alias Symbol: DPE2
Type: protein-coding gene Cytoband: 14q21.3
Entrez ID: 5427 HGNC ID: HGNC:9178 Ensembl Gene: ENSG00000100479 OMIM ID: 602670
Drug and gene relationship at DGIdb

 

POLE2 involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLE2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLE2 5427 205909_at 1.3883 0.1922
GSE20347 POLE2 5427 205909_at 1.3365 0.0000
GSE23400 POLE2 5427 205909_at 0.8018 0.0000
GSE26886 POLE2 5427 205909_at 0.5038 0.0978
GSE29001 POLE2 5427 205909_at 1.1762 0.0020
GSE38129 POLE2 5427 205909_at 1.5555 0.0000
GSE45670 POLE2 5427 205909_at 0.9479 0.0004
GSE53622 POLE2 5427 78492 1.1049 0.0000
GSE53624 POLE2 5427 87136 1.0694 0.0000
GSE63941 POLE2 5427 205909_at 3.2044 0.0001
GSE77861 POLE2 5427 205909_at 0.8021 0.1056
GSE97050 POLE2 5427 A_23_P163099 0.7371 0.1453
SRP007169 POLE2 5427 RNAseq 0.6525 0.1657
SRP008496 POLE2 5427 RNAseq 0.2115 0.5358
SRP064894 POLE2 5427 RNAseq 0.8450 0.0004
SRP133303 POLE2 5427 RNAseq 1.0659 0.0000
SRP159526 POLE2 5427 RNAseq 0.5692 0.1830
SRP193095 POLE2 5427 RNAseq 0.6052 0.0002
SRP219564 POLE2 5427 RNAseq 1.3695 0.0421
TCGA POLE2 5427 RNAseq 1.1432 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by POLE2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLE2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLE2 5427 7 2 21
GSE20123 POLE2 5427 7 3 20
GSE43470 POLE2 5427 9 1 33
GSE46452 POLE2 5427 16 3 40
GSE47630 POLE2 5427 11 10 19
GSE54993 POLE2 5427 3 9 58
GSE54994 POLE2 5427 19 4 30
GSE60625 POLE2 5427 0 2 9
GSE74703 POLE2 5427 7 1 28
GSE74704 POLE2 5427 2 2 16
TCGA POLE2 5427 34 13 49

Total number of gains: 115; Total number of losses: 50; Total Number of normals: 323.  

 

Somatic mutations of POLE2:

 

Generating mutation plots.

 

Highly correlated genes for POLE2:

 

Showing top 20/772 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLE2LRR10.865409707
POLE2CDKN30.80485912012
POLE2DLGAP50.79681413012
POLE2C1orf1120.78091808
POLE2CDC200.78010212012
POLE2BUB1B0.77935710010
POLE2CDC60.77231810010
POLE2GINS10.77058611011
POLE2CDCA20.767457505
POLE2TPX20.76414411010
POLE2VRK10.75973412012
POLE2RAD51AP10.75747112012
POLE2CENPN0.75364212011
POLE2KIF2C0.74960912012
POLE2NUBP10.748984303
POLE2STIL0.74376811010
POLE2CDCA50.743153808
POLE2DEPDC1B0.741432808
POLE2NUSAP10.74080710010
POLE2UBE2C0.74013511010

For details and further investigation, click here