ORC6

 

Full name: origin recognition complex subunit 6 Alias Symbol: 
Type: protein-coding gene Cytoband: 16q11.2
Entrez ID: 23594 HGNC ID: HGNC:17151 Ensembl Gene: ENSG00000091651 OMIM ID: 607213
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ORC6 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of ORC6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ORC6 23594 219105_x_at 1.2842 0.0182
GSE20347 ORC6 23594 219105_x_at 1.4967 0.0000
GSE23400 ORC6 23594 219105_x_at 0.5620 0.0000
GSE26886 ORC6 23594 219105_x_at 1.1283 0.0001
GSE29001 ORC6 23594 219105_x_at 1.0434 0.0005
GSE38129 ORC6 23594 219105_x_at 1.6856 0.0000
GSE45670 ORC6 23594 219105_x_at 1.1650 0.0000
GSE53622 ORC6 23594 117007 1.3144 0.0000
GSE53624 ORC6 23594 117007 1.3826 0.0000
GSE63941 ORC6 23594 219105_x_at 1.7166 0.0005
GSE77861 ORC6 23594 219105_x_at 1.1612 0.0011
GSE97050 ORC6 23594 A_23_P100344 0.2258 0.5340
SRP007169 ORC6 23594 RNAseq 2.3461 0.0000
SRP008496 ORC6 23594 RNAseq 1.9017 0.0000
SRP064894 ORC6 23594 RNAseq 1.1288 0.0004
SRP133303 ORC6 23594 RNAseq 1.5128 0.0000
SRP159526 ORC6 23594 RNAseq 1.9049 0.0000
SRP193095 ORC6 23594 RNAseq 1.0642 0.0000
SRP219564 ORC6 23594 RNAseq 1.6514 0.0094

Upregulated datasets: 17; Downregulated datasets: 0.  

 

Survival by ORC6 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of ORC6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ORC6 23594 2 1 27
GSE20123 ORC6 23594 2 1 27
GSE43470 ORC6 23594 2 7 34
GSE46452 ORC6 23594 38 1 20
GSE47630 ORC6 23594 11 7 22
GSE54993 ORC6 23594 2 5 63
GSE54994 ORC6 23594 6 10 37
GSE60625 ORC6 23594 4 0 7
GSE74703 ORC6 23594 2 4 30
GSE74704 ORC6 23594 2 1 17
TCGA ORC6 23594 29 11 56

Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.  

 

Somatic mutations of ORC6:

 

Generating mutation plots.

 

Highly correlated genes for ORC6:

 

Showing top 20/1097 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ORC6KIF18B0.83541611011
ORC6EME10.828683505
ORC6GINS10.82831711011
ORC6GINS20.81201312012
ORC6TTK0.80865611011
ORC6FANCI0.80753411011
ORC6TRIP130.80597812011
ORC6MTFR20.803694707
ORC6CDCA50.80299808
ORC6DTL0.80140711011
ORC6KPNA20.801224909
ORC6BUB1B0.79943410010
ORC6FEN10.79915310010
ORC6UBE2T0.797857707
ORC6NUF20.79719707
ORC6AURKA0.7956311011
ORC6KIF140.79509711011
ORC6BLM0.78715211011
ORC6ECT20.78709412012
ORC6KIF4A0.78469312012

For details and further investigation, click here