| Full name: spindle apparatus coiled-coil protein 1 | Alias Symbol: FLJ20364|hSpindly | ||
| Type: protein-coding gene | Cytoband: 5q35.1 | ||
| Entrez ID: 54908 | HGNC ID: HGNC:26010 | Ensembl Gene: ENSG00000040275 | OMIM ID: 616401 |
| Drug and gene relationship at DGIdb | |||
Expression of SPDL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPDL1 | 54908 | 221685_s_at | 0.7413 | 0.1411 | |
| GSE20347 | SPDL1 | 54908 | 221685_s_at | 0.7431 | 0.0001 | |
| GSE23400 | SPDL1 | 54908 | 221685_s_at | 0.4105 | 0.0000 | |
| GSE26886 | SPDL1 | 54908 | 221685_s_at | -0.1812 | 0.4653 | |
| GSE29001 | SPDL1 | 54908 | 221685_s_at | 1.0382 | 0.0003 | |
| GSE38129 | SPDL1 | 54908 | 221685_s_at | 0.9400 | 0.0000 | |
| GSE45670 | SPDL1 | 54908 | 221685_s_at | 1.0637 | 0.0000 | |
| GSE53622 | SPDL1 | 54908 | 77150 | 1.0827 | 0.0000 | |
| GSE53624 | SPDL1 | 54908 | 35289 | 1.2313 | 0.0000 | |
| GSE63941 | SPDL1 | 54908 | 221685_s_at | 0.2064 | 0.7993 | |
| GSE77861 | SPDL1 | 54908 | 221685_s_at | 0.4915 | 0.0939 | |
| SRP007169 | SPDL1 | 54908 | RNAseq | 1.1947 | 0.0046 | |
| SRP008496 | SPDL1 | 54908 | RNAseq | 0.4090 | 0.2135 | |
| SRP064894 | SPDL1 | 54908 | RNAseq | 1.0682 | 0.0000 | |
| SRP133303 | SPDL1 | 54908 | RNAseq | 1.4963 | 0.0000 | |
| SRP159526 | SPDL1 | 54908 | RNAseq | 0.6556 | 0.0290 | |
| SRP193095 | SPDL1 | 54908 | RNAseq | 0.3166 | 0.0046 | |
| SRP219564 | SPDL1 | 54908 | RNAseq | 0.5874 | 0.2198 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SPDL1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SPDL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDL1 | 54908 | 1 | 12 | 17 | |
| GSE20123 | SPDL1 | 54908 | 1 | 12 | 17 | |
| GSE43470 | SPDL1 | 54908 | 1 | 9 | 33 | |
| GSE46452 | SPDL1 | 54908 | 0 | 27 | 32 | |
| GSE47630 | SPDL1 | 54908 | 0 | 20 | 20 | |
| GSE54993 | SPDL1 | 54908 | 9 | 2 | 59 | |
| GSE54994 | SPDL1 | 54908 | 2 | 15 | 36 | |
| GSE60625 | SPDL1 | 54908 | 1 | 0 | 10 | |
| GSE74703 | SPDL1 | 54908 | 1 | 6 | 29 | |
| GSE74704 | SPDL1 | 54908 | 0 | 6 | 14 | |
| TCGA | SPDL1 | 54908 | 7 | 36 | 53 |
Total number of gains: 23; Total number of losses: 145; Total Number of normals: 320.
Somatic mutations of SPDL1:
Generating mutation plots.
Highly correlated genes for SPDL1:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDL1 | HMMR | 0.795942 | 10 | 0 | 10 |
| SPDL1 | KIF20A | 0.780779 | 10 | 0 | 10 |
| SPDL1 | DLGAP5 | 0.770208 | 10 | 0 | 9 |
| SPDL1 | KIF23 | 0.768602 | 10 | 0 | 10 |
| SPDL1 | CDC20 | 0.759166 | 10 | 0 | 9 |
| SPDL1 | CENPE | 0.758674 | 9 | 0 | 9 |
| SPDL1 | AURKB | 0.752176 | 9 | 0 | 9 |
| SPDL1 | XPR1 | 0.741469 | 5 | 0 | 5 |
| SPDL1 | WDHD1 | 0.740976 | 9 | 0 | 9 |
| SPDL1 | KIF4A | 0.738417 | 10 | 0 | 10 |
| SPDL1 | CDKN3 | 0.738029 | 10 | 0 | 9 |
| SPDL1 | PRKDC | 0.735764 | 9 | 0 | 9 |
| SPDL1 | MCM2 | 0.735752 | 9 | 0 | 9 |
| SPDL1 | TPX2 | 0.734512 | 10 | 0 | 9 |
| SPDL1 | HJURP | 0.734475 | 10 | 0 | 10 |
| SPDL1 | MTBP | 0.733791 | 4 | 0 | 4 |
| SPDL1 | UBE2C | 0.733144 | 10 | 0 | 9 |
| SPDL1 | CAD | 0.732282 | 9 | 0 | 9 |
| SPDL1 | CEP55 | 0.731624 | 11 | 0 | 10 |
| SPDL1 | SASS6 | 0.73077 | 5 | 0 | 5 |
For details and further investigation, click here
