| Full name: FKBP prolyl isomerase 1A | Alias Symbol: FKBP-12|FKBP12|PKC12|PPIASE|FKBP12C | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 2280 | HGNC ID: HGNC:3711 | Ensembl Gene: ENSG00000088832 | OMIM ID: 186945 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FKBP1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FKBP1A | 2280 | 200709_at | 0.3025 | 0.4083 | |
| GSE20347 | FKBP1A | 2280 | 200709_at | -0.1497 | 0.3232 | |
| GSE23400 | FKBP1A | 2280 | 200709_at | 0.1935 | 0.0045 | |
| GSE26886 | FKBP1A | 2280 | 200709_at | -0.7537 | 0.0082 | |
| GSE29001 | FKBP1A | 2280 | 200709_at | 0.0524 | 0.8469 | |
| GSE38129 | FKBP1A | 2280 | 200709_at | 0.0727 | 0.5827 | |
| GSE45670 | FKBP1A | 2280 | 200709_at | 0.3681 | 0.0345 | |
| GSE53622 | FKBP1A | 2280 | 6140 | 0.3539 | 0.0000 | |
| GSE53624 | FKBP1A | 2280 | 71764 | 0.1356 | 0.0134 | |
| GSE63941 | FKBP1A | 2280 | 200709_at | 1.0733 | 0.0044 | |
| GSE77861 | FKBP1A | 2280 | 200709_at | 0.0272 | 0.9067 | |
| GSE97050 | FKBP1A | 2280 | A_24_P160001 | 0.4769 | 0.2495 | |
| SRP007169 | FKBP1A | 2280 | RNAseq | -0.9007 | 0.0045 | |
| SRP008496 | FKBP1A | 2280 | RNAseq | -0.6714 | 0.0004 | |
| SRP064894 | FKBP1A | 2280 | RNAseq | 0.7567 | 0.0009 | |
| SRP133303 | FKBP1A | 2280 | RNAseq | 0.2454 | 0.0991 | |
| SRP159526 | FKBP1A | 2280 | RNAseq | 0.3714 | 0.1231 | |
| SRP193095 | FKBP1A | 2280 | RNAseq | -0.0614 | 0.6237 | |
| SRP219564 | FKBP1A | 2280 | RNAseq | 0.3585 | 0.1940 | |
| TCGA | FKBP1A | 2280 | RNAseq | 0.1417 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FKBP1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FKBP1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FKBP1A | 2280 | 13 | 3 | 14 | |
| GSE20123 | FKBP1A | 2280 | 14 | 3 | 13 | |
| GSE43470 | FKBP1A | 2280 | 11 | 1 | 31 | |
| GSE46452 | FKBP1A | 2280 | 26 | 1 | 32 | |
| GSE47630 | FKBP1A | 2280 | 19 | 4 | 17 | |
| GSE54993 | FKBP1A | 2280 | 2 | 14 | 54 | |
| GSE54994 | FKBP1A | 2280 | 24 | 2 | 27 | |
| GSE60625 | FKBP1A | 2280 | 0 | 0 | 11 | |
| GSE74703 | FKBP1A | 2280 | 10 | 1 | 25 | |
| GSE74704 | FKBP1A | 2280 | 9 | 1 | 10 | |
| TCGA | FKBP1A | 2280 | 40 | 11 | 45 |
Total number of gains: 168; Total number of losses: 41; Total Number of normals: 279.
Somatic mutations of FKBP1A:
Generating mutation plots.
Highly correlated genes for FKBP1A:
Showing top 20/85 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FKBP1A | SNRPB | 0.651333 | 9 | 0 | 7 |
| FKBP1A | MS4A6A | 0.642514 | 3 | 0 | 3 |
| FKBP1A | ESRRA | 0.628151 | 3 | 0 | 3 |
| FKBP1A | TRPV4 | 0.624691 | 3 | 0 | 3 |
| FKBP1A | GAPDH | 0.623445 | 4 | 0 | 3 |
| FKBP1A | SRXN1 | 0.618766 | 3 | 0 | 3 |
| FKBP1A | PCSK7 | 0.61383 | 3 | 0 | 3 |
| FKBP1A | LST1 | 0.604496 | 3 | 0 | 3 |
| FKBP1A | PCNA | 0.585777 | 8 | 0 | 6 |
| FKBP1A | S100A11 | 0.585518 | 5 | 0 | 3 |
| FKBP1A | CDSN | 0.584167 | 5 | 0 | 3 |
| FKBP1A | CSNK2B | 0.581634 | 5 | 0 | 4 |
| FKBP1A | CDC25B | 0.575214 | 6 | 0 | 4 |
| FKBP1A | CORO1B | 0.568857 | 5 | 0 | 3 |
| FKBP1A | CENPI | 0.564748 | 4 | 0 | 3 |
| FKBP1A | IL2RG | 0.564189 | 4 | 0 | 3 |
| FKBP1A | XRN2 | 0.564064 | 5 | 0 | 4 |
| FKBP1A | CTDNEP1 | 0.563628 | 5 | 0 | 4 |
| FKBP1A | AP2M1 | 0.562784 | 5 | 0 | 3 |
| FKBP1A | ATRN | 0.559673 | 7 | 0 | 5 |
For details and further investigation, click here
